PMID- 35939402
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221101
IS  - 1743-5404 (Electronic)
IS  - 1743-5390 (Linking)
VI  - 16
IP  - 4
DP  - 2022 May
TI  - Gestational exposure to silver nanoparticles enhances immune adaptation and 
      protection against streptozotocin-induced diabetic nephropathy in mice offspring.
PG  - 450-471
LID - 10.1080/17435390.2022.2098863 [doi]
AB  - Silver nanoparticles (AgNPs) possess unique antimicrobial properties. As a 
      result, they are being increasingly used in a wide range of applications. Several 
      studies have shown detrimental effects of AgNPs exposure, including inflammation, 
      accumulation, and cellular damage to different organs. However, the effect of 
      AgNPs exposure during gestation, a critical and susceptible period of human 
      development, on pregnant females and its long-term effects on offspring's health 
      has not been studied. Therefore, we conducted a long-term study where we assessed 
      the effect of gestational AgNPs exposure on pregnant mice and followed their 
      offspring until the age of 12 months. Gestational exposure to AgNPs induced 
      systemic inflammation in the pregnant mice at gestational day (GD) 18. 
      Interestingly, developing fetuses exposed to AgNPs, showed anti-inflammatory 
      conditions as indicated by reduced expression of inflammatory genes in fetal 
      organs at GD 18 and reduced serum levels of TNF-alpha, IFN-gamma, IL-17A, IL-6, and MCP-1 
      in AgNPs exposed pups at postnatal day (PD) 2. Surprisingly, post-weaning, AgNPs 
      exposed offspring showed a heightened immune activation as shown by upregulation 
      of inflammatory cytokines at PD 28, which persisted till late in life. Moreover, 
      we observed metabolic alterations which persisted until adulthood in mice. To 
      understand the impact of long-term immunometabolic changes on the progression of 
      diabetes and kidney diseases under stressed conditions, we exposed offspring to 
      streptozotocin which revealed a protective role of low-dose gestational AgNPs 
      exposure against streptozotocin-induced diabetes and associated nephropathy.
FAU - Tiwari, Ratnakar
AU  - Tiwari R
AD  - Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment 
      Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
AD  - Department of Biochemistry, School of Dental Sciences, Babu Banarasi Das 
      University, Lucknow, India.
AD  - Division of Nephrology and Feinberg Cardiovascular and Renal Research Institute, 
      Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
FAU - Singh, Radha Dutt
AU  - Singh RD
AD  - Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment 
      Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
FAU - Singh, Sukhveer
AU  - Singh S
AD  - Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment 
      Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
FAU - Singh, Diksha
AU  - Singh D
AD  - Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment 
      Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
FAU - Srivastav, Anurag Kumar
AU  - Srivastav AK
AD  - Animal House Facility, Regulatory Toxicology Group, CSIR-Indian Institute of 
      Toxicology Research, Lucknow, India.
FAU - Kumar, Mahadeo
AU  - Kumar M
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
AD  - Animal House Facility, Regulatory Toxicology Group, CSIR-Indian Institute of 
      Toxicology Research, Lucknow, India.
FAU - Srivastava, Vikas
AU  - Srivastava V
AD  - Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment 
      Group, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
AD  - Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220808
PL  - England
TA  - Nanotoxicology
JT  - Nanotoxicology
JID - 101233132
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 3M4G523W1G (Silver)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cytokines/genetics/metabolism
MH  - *Diabetes Mellitus
MH  - *Diabetic Nephropathies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Inflammation
MH  - Interleukin-17
MH  - Interleukin-6
MH  - *Metal Nanoparticles/toxicity
MH  - Mice
MH  - Pregnancy
MH  - Silver/toxicity
MH  - Streptozocin
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Silver nanoparticles
OT  - gestational exposure
OT  - immunometabolic alterations
OT  - kidney damage
EDAT- 2022/08/09 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/08/08 13:03
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/08/08 13:03 [entrez]
AID - 10.1080/17435390.2022.2098863 [doi]
PST - ppublish
SO  - Nanotoxicology. 2022 May;16(4):450-471. doi: 10.1080/17435390.2022.2098863. Epub 
      2022 Aug 8.