PMID- 35940230 OWN - NLM STAT- MEDLINE DCOM- 20220914 LR - 20220929 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 214 IP - Pt 3 DP - 2022 Nov TI - Association between exposure to a mixture of metals, parabens, and phthalates and fractional exhaled nitric oxide: A population-based study in US adults. PG - 113962 LID - S0013-9351(22)01289-0 [pii] LID - 10.1016/j.envres.2022.113962 [doi] AB - The effects of environmental endocrine-disrupting chemicals (EDCs) (e.g., phthalates) on fractional exhaled nitric oxide (FeNO) in children have received much attention. However, few studies evaluated this relationship in adults, and the previous studies have considered only a unitary exposure or a set of similar exposures instead of mixed exposures, which contain complicated interactions. We aimed to evaluate simultaneously the relationship between three types of EDCs (six phthalate metabolites and two parabens in urine, two heavy metals in blood) and FeNO (as a continuous variable) in adults. Data of adults aged >/=20 years from the National Health and Nutrition Examination Survey (NHANES, 2007-2012) were collected and analyzed. The generalized linear (GLM) regression model was used to explore the association of chemicals with FeNO. The combined effect of 10 chemicals on the overall association with FeNO was evaluated by the weighted quantile sum regression (WQS) model. In addition, The Bayesian kernel machine regression (BKMR) model was explored to investigate the interaction and joint effects of multiple chemicals with FeNO. Of the 3296 study participants ultimately included, among the GLMs, we found that mercury (Hg) (beta = 0.84, 95%CI:0.32-1.36, FDR = 0.01) and methyl paraben (MPB) (beta = 0.47, 95%CI:0.16-0.78, FDR = 0.015) were positively correlated with FeNO. In the WQS model, the combined effect of chemicals almost had a significantly positive association with FeNO and the top three contributors to the WQS index were Hg (40.2%), MECPP (22.1%), and MPB (19.3%). BKMR analysis showed that there may be interactions between MPB and Hg, Mono (carboxyoctyl) phthalate (MCOP) and Hg and the overall effect of the mixture showed a positive correlation with FeNO. In conclusion, our study strengthens the credibility of the view that EDCs can affect respiratory health. In the future, we should be particularly careful with products containing Hg, MECPP, MPB, and MEHP for the prevention of respiratory diseases. CI - Copyright (c) 2022. Published by Elsevier Inc. FAU - Wu, Yudong AU - Wu Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Song, Jian AU - Song J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Li, Yuxuan AU - Li Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Jin, Xiaoyu AU - Jin X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Liang, Yunfeng AU - Liang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Qin, Wei AU - Qin W AD - Lu'an Municipal Center for Disease Control and Prevention, Lu'an, Anhui, China. FAU - Yi, Weizhuo AU - Yi W AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Pan, Rubing AU - Pan R AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Yan, Shuangshuang AU - Yan S AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Sun, Xiaoni AU - Sun X AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Mei, Lu AU - Mei L AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Song, Shasha AU - Song S AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Cheng, Jian AU - Cheng J AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. FAU - Su, Hong AU - Su H AD - Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, 230032, China. Electronic address: suhong5151@sina.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220805 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Endocrine Disruptors) RN - 0 (Environmental Pollutants) RN - 0 (Parabens) RN - 0 (Phthalic Acids) RN - 31C4KY9ESH (Nitric Oxide) RN - 6O7F7IX66E (phthalic acid) RN - FXS1BY2PGL (Mercury) SB - IM MH - Adult MH - Bayes Theorem MH - Child MH - *Endocrine Disruptors MH - Environmental Exposure/analysis MH - *Environmental Pollutants/urine MH - Fractional Exhaled Nitric Oxide Testing MH - Humans MH - *Mercury MH - Nitric Oxide MH - Nutrition Surveys MH - Parabens MH - *Phthalic Acids/urine OTO - NOTNLM OT - BKMR OT - Fractional exhaled nitric oxide OT - Metals OT - Parabens OT - Phthalates OT - WQS COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/08/09 06:00 MHDA- 2022/09/15 06:00 CRDT- 2022/08/08 19:32 PHST- 2022/05/20 00:00 [received] PHST- 2022/07/19 00:00 [revised] PHST- 2022/07/20 00:00 [accepted] PHST- 2022/08/09 06:00 [pubmed] PHST- 2022/09/15 06:00 [medline] PHST- 2022/08/08 19:32 [entrez] AID - S0013-9351(22)01289-0 [pii] AID - 10.1016/j.envres.2022.113962 [doi] PST - ppublish SO - Environ Res. 2022 Nov;214(Pt 3):113962. doi: 10.1016/j.envres.2022.113962. Epub 2022 Aug 5.