PMID- 35940311
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220922
IS  - 1872-9096 (Electronic)
IS  - 0166-3542 (Linking)
VI  - 206
DP  - 2022 Oct
TI  - Matrix metalloproteinase 3 restricts viral infection by enhancing host antiviral 
      immunity.
PG  - 105388
LID - S0166-3542(22)00157-7 [pii]
LID - 10.1016/j.antiviral.2022.105388 [doi]
AB  - Viral pandemics pose great threats to human health and the economy. The host 
      evolved a complex immune response against viral infection. Matrix 
      metalloproteinase 3 (MMP3), also known as stromelysin-1, has an emerging role in 
      immune regulation during pathogen infection. Using in vitro and in vivo infection 
      models, we showed that MMP3 exhibits broad-spectrum antiviral activities against 
      vesicular stomatitis virus (VSV), influenza A virus (H1N1) and human herpes virus 
      1 (HSV-1). MMP3 deficient mice are susceptible to viral infection and display a 
      compromised antiviral immune response. Correspondingly, the mice with MMP3 
      overexpression are resistant to viral infection. The mechanistic study suggested 
      that MMP3 is translocated from the cytoplasm into the cell nucleus upon virus 
      infection and influence NF-kappaB activities, thus amplifying antiviral immune 
      responses. This study suggested a novel function of MMP3 in viral infection and 
      provided new ideas for developing antiviral drugs based on modulating MMP 
      activity.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Feng, Tingting
AU  - Feng T
AD  - Department of Respiratory Medicine, Children's Hospital of Soochow University, 
      Soochow University, Suzhou, China; Institutes of Biology and Medical Sciences, 
      Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, 
      China. Electronic address: ttfeng@suda.edu.cn.
FAU - Tong, Hao
AU  - Tong H
AD  - Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection 
      and Immunity, Soochow University, Suzhou, China. Electronic address: 
      touch42@163.com.
FAU - Ming, Zhihao
AU  - Ming Z
AD  - Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection 
      and Immunity, Soochow University, Suzhou, China. Electronic address: 
      zhihaoming8@163.com.
FAU - Deng, Lei
AU  - Deng L
AD  - Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection 
      and Immunity, Soochow University, Suzhou, China. Electronic address: 
      dengleistory@163.com.
FAU - Liu, Jiayan
AU  - Liu J
AD  - Department of Radiology, Dushu Lake Hospital Affiliated to Soochow University, 
      Suzhou, China. Electronic address: 13147701959@163.com.
FAU - Wu, Jiahui
AU  - Wu J
AD  - Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection 
      and Immunity, Soochow University, Suzhou, China. Electronic address: 
      1830401145@stu.suda.edu.cn.
FAU - Chen, Zhengrong
AU  - Chen Z
AD  - Department of Respiratory Medicine, Children's Hospital of Soochow University, 
      Soochow University, Suzhou, China. Electronic address: chen_zheng_rong@163.com.
FAU - Yan, Yongdong
AU  - Yan Y
AD  - Department of Respiratory Medicine, Children's Hospital of Soochow University, 
      Soochow University, Suzhou, China. Electronic address: yyd3060@126.com.
FAU - Dai, Jianfeng
AU  - Dai J
AD  - Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection 
      and Immunity, Soochow University, Suzhou, China. Electronic address: 
      daijianfeng@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220806
PL  - Netherlands
TA  - Antiviral Res
JT  - Antiviral research
JID - 8109699
RN  - 0 (Antiviral Agents)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.17 (Mmp3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/pharmacology
MH  - Humans
MH  - Immunity, Innate
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Matrix Metalloproteinase 3/genetics/*metabolism
MH  - Mice
MH  - *Virus Diseases
MH  - Virus Replication
OTO - NOTNLM
OT  - Antiviral response
OT  - Immune regulation
OT  - Innate immunity
OT  - Matrix metalloproteinase
OT  - Virus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/09 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/08 19:34
PHST- 2022/05/12 00:00 [received]
PHST- 2022/07/14 00:00 [revised]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/08 19:34 [entrez]
AID - S0166-3542(22)00157-7 [pii]
AID - 10.1016/j.antiviral.2022.105388 [doi]
PST - ppublish
SO  - Antiviral Res. 2022 Oct;206:105388. doi: 10.1016/j.antiviral.2022.105388. Epub 
      2022 Aug 6.