PMID- 35940407
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20220928
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 307
IP  - Pt 2
DP  - 2022 Nov
TI  - Assessment for the associations of twenty-three metal(loid)s exposures with early 
      cardiovascular damage among Chinese urban adults with five statistical methods: 
      Insight into assessing health effect of multipollutant exposure.
PG  - 135969
LID - S0045-6535(22)02462-6 [pii]
LID - 10.1016/j.chemosphere.2022.135969 [doi]
AB  - The topic of cardiovascular hazards from multiple metal (loid)s exposures has 
      attracted widespread attention. Here, we measured concentrations of twenty-three 
      urinary metal (loid)s and mean platelet volume (MPV), an early cardiovascular 
      damage biomarker, for 3396 Chinese adults. We aimed to comprehensively assess the 
      associations of single metal (loid) and multiple metal (loid)s (as a mixture) 
      with MPV by combined use of five statistical methods, including general linear 
      models, Bayesian kernel machine regression (BKMR), weight quartile sum (WQS) 
      regression, quantile g-computation (QGC), and adaptive elastic network regression 
      (AENR). And based on that, we hope to provide insight into assessing the health 
      effect of multipollutant exposure. After adjustment for potential covariates, at 
      least three methods jointly suggested that of twenty-three metal (loid)s, iron, 
      arsenic, and antimony were positively while aluminum, tungsten, and thallium were 
      inversely associated with MPV. The environmental risk score of metal (loid)s 
      construed by AENR was significantly positively associated with MPV, while the 
      association between overall twenty-three metal (loid)s mixture and MPV was 
      neutralized to be insignificant in QGC and BKMR. Conclusively, single metal 
      (loid) may be inversely (iron, arsenic, and antimony) and positively (aluminum, 
      tungsten, and thallium) associated with early cardiovascular damage, while the 
      association of overall twenty-three metal (loid)s mixture with MPV was 
      insignificant when concurrent exposures exist. It is crucial to select 
      appropriate statistical methods based on study purpose and 
      principles/characteristics of statistical methods, and combined employment of 
      multimethod is insightfully suggested when assessing health effects of 
      multipollutant exposure.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Yu, Linling
AU  - Yu L
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Ye, Zi
AU  - Ye Z
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Wang, Xing
AU  - Wang X
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Qiu, Weihong
AU  - Qiu W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Tan, Qiyou
AU  - Tan Q
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Nie, Xiuquan
AU  - Nie X
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Li, Minjing
AU  - Li M
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic 
      address: gentwong@163.com.
FAU - Chen, Weihong
AU  - Chen W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of 
      Education & Ministry of Environmental Protection, and State Key Laboratory of 
      Environmental Health, School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic 
      address: wchen@mails.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220806
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Metals)
RN  - 0 (Metals, Heavy)
RN  - 9IT35J3UV3 (Antimony)
RN  - AD84R52XLF (Thallium)
RN  - CPD4NFA903 (Aluminum)
RN  - E1UOL152H7 (Iron)
RN  - N712M78A8G (Arsenic)
RN  - V9306CXO6G (Tungsten)
SB  - IM
MH  - Aluminum
MH  - Antimony
MH  - *Arsenic/analysis
MH  - Bayes Theorem
MH  - China
MH  - Iron
MH  - Metals/toxicity
MH  - *Metals, Heavy
MH  - Thallium
MH  - Tungsten
OTO - NOTNLM
OT  - Early cardiovascular damage
OT  - Health effect
OT  - Mean platelet volume
OT  - Multipollutant mixture exposure
OT  - Urinary metal(loid)s
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/09 06:00
MHDA- 2022/09/28 06:00
CRDT- 2022/08/08 19:36
PHST- 2022/03/29 00:00 [received]
PHST- 2022/06/21 00:00 [revised]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/08/08 19:36 [entrez]
AID - S0045-6535(22)02462-6 [pii]
AID - 10.1016/j.chemosphere.2022.135969 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Nov;307(Pt 2):135969. doi: 10.1016/j.chemosphere.2022.135969. 
      Epub 2022 Aug 6.