PMID- 35941556 OWN - NLM STAT- MEDLINE DCOM- 20220810 LR - 20220811 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 22 IP - 1 DP - 2022 Aug 8 TI - Nutrition mediates the relationship between number of teeth and sarcopenia: a pathway analysis. PG - 649 LID - 10.1186/s12877-022-03350-7 [doi] LID - 649 AB - OBJECTIVES: The relationship between the number of teeth and sarcopenia remains poorly investigated. Although nutrition plays an important role in maintaining bone and muscle health, the complex relationship between number of teeth and nutrition in the pathogenesis of sarcopenia remains to be elucidated. METHODS: A large multi-ethnic sample of 4149 participants aged over 50 years old from West China Health and Aging Trend (WCHAT) study was analyzed. We examined the associations between number of teeth with nutritional status and sarcopenia, and the mediating role of nutrition in the association between number of teeth and sarcopenia. Sarcopenia was defined according to the Asian Working Group for Sarcopenia 2019. We assessed nutrition using Mini Nutrition Assessment-Short Form (MNA-SF) scale. Direct relationships between number of teeth, nutrition and sarcopenia were assessed using multiple linear regression. Mediation models and structural equation model (SEM) pathway analysis were used to test the mediating role of nutrition in the relationship between number of teeth and sarcopenia. RESULTS: Of 4149 participants aged 50 years old or older, the prevalence of sarcopenia was 22.5, 9.0% for moderate sarcopenia, and 13.5% for severe sarcopenia, respectively. Regression analysis indicated a total association between number of teeth (beta = - 0.327, 95% CI - 0.471 to - 0.237, p < 0.001) and sarcopenia. After adjusted MNA-SF scores, the association between number of teeth and sarcopenia was still significant (beta = - 0.269, 95% CI - 0.364 to - 0.175, p < 0.001), indicating a partial mediation effect of nutrition. Mediation analysis verified nutrition partially mediate the associations between number of teeth and sarcopenia (indirect effect estimate = - 0.0272, bootstrap 95% CI - 0.0324 to - 0.0222; direct effect estimate = - 0.0899, bootstrap 95% CI - 0.1049 to - 0.0738). And this mediation effect was through impacting SMI (indirect effect estimate = - 0.0283, bootstrap 95% CI - 0.0336 to - 0.0232) and grip strength (indirect effect estimate = - 0.0067, bootstrap 95% CI - 0.0094 to - 0.0043). Structural equation model (SEM) framework pathway analysis confirmed the association between number of teeth, nutrition, and sarcopenia. CONCLUSIONS: Our findings indicated that sarcopenia was associated with number of teeth and poorer nutritional status, with nutrition partially mediating the association between number of teeth and sarcopenia. Our findings supported early nutritional assessment and intervention in oral health to mitigate the risk of sarcopenia. CI - (c) 2022. The Author(s). FAU - Xia, Xin AU - Xia X AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. FAU - Xu, Zhigang AU - Xu Z AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. FAU - Hu, Fengjuan AU - Hu F AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. FAU - Hou, Lisha AU - Hou L AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. FAU - Zhang, Gongchang AU - Zhang G AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. FAU - Liu, Xiaolei AU - Liu X AD - National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan, China. xiaolei1823@163.com. AD - Geriatric Health Care and Medical Research Center, Sichuan University, Sichuan Province, Chengdu, China. xiaolei1823@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220808 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 SB - IM MH - Aged MH - Cross-Sectional Studies MH - Geriatric Assessment MH - Hand Strength MH - Humans MH - Middle Aged MH - Nutrition Assessment MH - Nutritional Status MH - *Sarcopenia/diagnosis/epidemiology PMC - PMC9360705 OTO - NOTNLM OT - Mediation OT - Number of teeth OT - Nutrition OT - Sarcopenia COIS- None. EDAT- 2022/08/09 06:00 MHDA- 2022/08/11 06:00 PMCR- 2022/08/08 CRDT- 2022/08/08 23:44 PHST- 2022/05/03 00:00 [received] PHST- 2022/07/30 00:00 [accepted] PHST- 2022/08/08 23:44 [entrez] PHST- 2022/08/09 06:00 [pubmed] PHST- 2022/08/11 06:00 [medline] PHST- 2022/08/08 00:00 [pmc-release] AID - 10.1186/s12877-022-03350-7 [pii] AID - 3350 [pii] AID - 10.1186/s12877-022-03350-7 [doi] PST - epublish SO - BMC Geriatr. 2022 Aug 8;22(1):649. doi: 10.1186/s12877-022-03350-7.