PMID- 35941893
OWN - NLM
STAT- MEDLINE
DCOM- 20220810
LR  - 20220810
IS  - 1748-6718 (Electronic)
IS  - 1748-670X (Print)
IS  - 1748-670X (Linking)
VI  - 2022
DP  - 2022
TI  - Efficacy of Gamma Globulins in Children with Kawasaki Disease and Factors 
      Influencing Children's Short-Term Prognosis.
PG  - 5137874
LID - 10.1155/2022/5137874 [doi]
LID - 5137874
AB  - PURPOSE: To explore and analyze the therapeutic effect of gamma globulins (GG) on 
      Kawasaki disease (KD) in children and the influencing factors of short-term 
      prognosis. METHODS: First, 90 pediatric KD patients admitted between January 2019 
      and January 2021 were selected and divided into a control group (n = 40) and a 
      research group (n = 50) according to the difference in treatment. In addition to 
      routine treatment and nursing given to both groups, control group was given 
      aspirin (ASA), based on which research group was supplemented with GG therapy. 
      The treatment outcome and adverse events (AEs) of the two cohorts of patients 
      were analyzed and compared, and the influencing factors of children's short-term 
      prognosis were analyzed by logistics multivariate analysis. RESULTS: Research 
      group had a statistical higher overall response rate than control group, with 
      significantly fewer cases suffering from AEs such as nausea and vomiting, 
      diarrhea, rash, dizziness and headache, and coronary artery injury. On the other 
      hand, logistics multivariate analysis identified that gender, body mass index 
      (BMI), onset time, platelet (PLT), and treatment mode all independently influence 
      the short-term prognosis of children with KD. CONCLUSIONS: GG therapy is 
      effective in treating pediatric KD patients and can effectively prevent AEs. In 
      addition, gender, BMI, onset-to-treatment time, PLT, C-reactive protein (CRP), 
      and treatment methods are independent risk factors for short-term prognosis of 
      children with KD.
CI  - Copyright (c) 2022 Hao Sun et al.
FAU - Sun, Hao
AU  - Sun H
AUID- ORCID: 0000-0002-7740-3014
AD  - Department of General Paediatrics, Children's Hospital of Shanxi, Taiyuan City, 
      030000 Shanxi, China.
FAU - Lu, Huimin
AU  - Lu H
AD  - Department of General Paediatrics, Children's Hospital of Shanxi, Taiyuan City, 
      030000 Shanxi, China.
FAU - Wu, Yunhong
AU  - Wu Y
AD  - Department of General Paediatrics, Children's Hospital of Shanxi, Taiyuan City, 
      030000 Shanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20220730
PL  - United States
TA  - Comput Math Methods Med
JT  - Computational and mathematical methods in medicine
JID - 101277751
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (gamma-Globulins)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - Child
MH  - *Coronary Artery Disease/drug therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - *Mucocutaneous Lymph Node Syndrome/complications/drug therapy
MH  - Prognosis
MH  - Retrospective Studies
MH  - gamma-Globulins/therapeutic use
PMC - PMC9356834
COIS- The authors declare no competing interests.
EDAT- 2022/08/10 06:00
MHDA- 2022/08/11 06:00
PMCR- 2022/07/30
CRDT- 2022/08/09 01:55
PHST- 2022/06/07 00:00 [received]
PHST- 2022/07/04 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/08/09 01:55 [entrez]
PHST- 2022/08/10 06:00 [pubmed]
PHST- 2022/08/11 06:00 [medline]
PHST- 2022/07/30 00:00 [pmc-release]
AID - 10.1155/2022/5137874 [doi]
PST - epublish
SO  - Comput Math Methods Med. 2022 Jul 30;2022:5137874. doi: 10.1155/2022/5137874. 
      eCollection 2022.