PMID- 3594404
OWN - NLM
STAT- MEDLINE
DCOM- 19870819
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 60
IP  - 4
DP  - 1987 Aug 15
TI  - Clinical and laboratory observations in a lymphoma-prone family.
PG  - 864-9
AB  - Three sisters developed non-Hodgkin's lymphoma (NHL). Thirteen maternal relatives 
      had adenocarcinomas of various types, predominantly breast and large bowel. 
      Detailed laboratory assessment of this family revealed a variety of immunologic 
      abnormalities. Two lymphoma patients had elevated anti-early antigens (EA) 
      Epstein-Barr virus (EBV) titers. One of the two also had a markedly elevated 
      anti-viral capsid antigen (VCA) EBV titer. The two lymphoma patients were human 
      leukocyte antigen (HLA)-identical, but two unaffected siblings shared the same 
      HLA haplotypes. One of the lymphoma patients and four unaffected family members 
      were anergic; and three unaffected family members had a decreased percentage of 
      T-cells. These data suggest that a subtle disturbance in cellular immune 
      functions may play a causal role in some familial aggregations of malignant 
      lymphoma.
FAU - Clark, J W
AU  - Clark JW
FAU - Tucker, M A
AU  - Tucker MA
FAU - Greene, M H
AU  - Greene MH
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Aged
MH  - Blood Protein Electrophoresis
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/blood/*genetics/immunology
MH  - Male
MH  - Medical History Taking
MH  - Middle Aged
MH  - Pedigree
EDAT- 1987/08/15 00:00
MHDA- 1987/08/15 00:01
CRDT- 1987/08/15 00:00
PHST- 1987/08/15 00:00 [pubmed]
PHST- 1987/08/15 00:01 [medline]
PHST- 1987/08/15 00:00 [entrez]
AID - 10.1002/1097-0142(19870815)60:4<864::aid-cncr2820600424>3.0.co;2-t [doi]
PST - ppublish
SO  - Cancer. 1987 Aug 15;60(4):864-9. doi: 
      10.1002/1097-0142(19870815)60:4<864::aid-cncr2820600424>3.0.co;2-t.