PMID- 35944243
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20230802
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 45
IP  - 12
DP  - 2022 Dec 1
TI  - Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older 
      Adults With Type 1 or Type 2 Diabetes.
PG  - 2999-3006
LID - 10.2337/dc22-0177 [doi]
AB  - OBJECTIVE: To examine the association between microvascular disease (MVD) and 
      risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) 
      or type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We included 
      1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK 
      Biobank who were free of HF during enrollment. MVD burden reflected by the 
      presence of retinopathy, peripheral neuropathy, and chronic kidney disease (CKD) 
      at baseline was prospectively evaluated for the association with incidence of HF. 
      Hazard ratios (HRs) and 95% CIs of HF were estimated by Cox regression models 
      adjusted for multiple traditional risk factors. RESULTS: There were 145 and 2,515 
      incident cases of HF recorded among participants with T1DM and T2DM, 
      respectively, during a median follow-up of 11.5 years. The association between 
      the number of MVD and HF was stronger among participants with T1DM than among 
      those with T2DM (P for interaction <0.001). Compared with participants with no 
      MVD, those with all three MVD had an adjusted HR (95% CI) of 11.37 (5.62, 22.99) 
      in T1DM and 3.66 (2.74, 4.88) in T2DM. In T1DM, HRs (CIs) were 2.69 (1.75, 4.14) 
      for retinopathy, 2.11 (1.38, 3.23) for peripheral neuropathy, and 2.21 (1.53, 
      3.18) for CKD. The corresponding estimates in T2DM were 1.24 (1.13, 1.36), 1.63 
      (1.36, 1.96), and 1.73 (1.59, 1.89), respectively. CONCLUSIONS: While a heavier 
      burden of MVD was associated with excess risk of HF both in T1DM and T2DM, the 
      association was evidently more pronounced in T1DM.
CI  - (c) 2022 by the American Diabetes Association.
FAU - Li, Fu-Rong
AU  - Li FR
AD  - Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern 
      University of Science and Technology, Shenzhen, China.
AD  - Department of Epidemiology, School of Public Health, Southern Medical University, 
      Guangzhou, Guangdong, China.
AD  - School of Public Health and Emergency Management, Southern University of Science 
      and Technology, Shenzhen, China.
FAU - Hukportie, Daniel Nyarko
AU  - Hukportie DN
AD  - Department of Epidemiology, School of Public Health, Southern Medical University, 
      Guangzhou, Guangdong, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
AD  - Department of Clinical Nutrition, The First Affiliated Hospital of Soochow 
      University, Suzhou, China.
FAU - Yang, Huan-Huan
AU  - Yang HH
AD  - Vanke School of Public Health, Tsinghua University, Beijing, China.
FAU - Chen, Guo-Chong
AU  - Chen GC
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, NY.
FAU - Wu, Xian-Bo
AU  - Wu XB
AUID- ORCID: 0000-0003-1606-5178
AD  - Department of Epidemiology, School of Public Health, Southern Medical University, 
      Guangzhou, Guangdong, China.
LA  - eng
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
CIN - Diabetes Care. 2022 Dec 1;45(12):2817-2819. PMID: 36455129
MH  - Middle Aged
MH  - Humans
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Diabetes Mellitus, Type 1/complications/epidemiology
MH  - *Heart Failure/epidemiology/complications
MH  - Incidence
MH  - Risk Factors
MH  - *Renal Insufficiency, Chronic/complications
MH  - *Retinal Diseases
EDAT- 2022/08/10 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/08/09 16:32
PHST- 2022/01/27 00:00 [received]
PHST- 2022/07/03 00:00 [accepted]
PHST- 2022/08/10 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/08/09 16:32 [entrez]
AID - 147411 [pii]
AID - 10.2337/dc22-0177 [doi]
PST - ppublish
SO  - Diabetes Care. 2022 Dec 1;45(12):2999-3006. doi: 10.2337/dc22-0177.