PMID- 35944761
OWN - NLM
STAT- MEDLINE
DCOM- 20220920
LR  - 20220921
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 92
DP  - 2022 Sep
TI  - Effects of prenatal and infant daily exposure to pyrethroid pesticides on the 
      language development of 2-year-old toddlers: A prospective cohort study in rural 
      Yunnan, China.
PG  - 180-190
LID - S0161-813X(22)00125-5 [pii]
LID - 10.1016/j.neuro.2022.08.002 [doi]
AB  - BACKGROUND: Prenatal and infant daily exposures to pyrethroid pesticides (PYRs), 
      used in the elimination of harmful organisms in the family environment and 
      agricultural activities, may have an impact on children's language development. 
      OBJECTIVES: To determine the impacts of prenatal and infant PYRs exposure on 
      2-year-old toddlers' language development. METHODS: From January 2016 to December 
      2018, women in the third trimester of pregnancy, in Yunnan rural area, China, 
      were recruited, and the development of their newborns was observed from birth 
      till the age of two. We examined three PYRs metabolites: 3-phenoxybenzoic acid 
      (3PBA), 4-fluoro-3-phenoxybenzoic acid (4F3PBA), and 
      cis-2,2dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA) in urine 
      samples collected from women in the third trimester of pregnancy and their 
      infants of 6-8 months after birth, and assessed language development of 
      2-year-old toddlers by the Bayley Scales of Infant and Toddler Development-Third 
      Edition (BSID-III). Generalized linear models were used to analyze the impacts of 
      exposure to PYRs on 2-year-old toddlers' language development. RESULTS: The 
      median concentrations of 3PBA, 4F3PBA and DBCA creatinine-adjusted were 0.21, 
      0.19, and 0.15 mug/g in pregnancy, and 0.25, 0.72, and <LOD mug/g in infancy, 
      respectively. The average scores of Language Composite (LC), Receptive 
      Communication (RC), and Expressive Communication (EC) in 2-year-old toddlers were 
      100.0 +/- 16.5, 10.0 +/- 3.1, and 10.0 +/- 3.1, respectively. Multiple linear 
      regression analyses manifested that the concentration of 4F3PBA in infancy was 
      negatively correlated with toddlers' RC scores [beta = -0.43 (95 % CI: -0.85, 
      -0.01), p = 0.046]; the total PYRs metabolites in infancy were negatively 
      correlated with boys' LC scores and RC scores [beta = -1.14 (95 % CI: -2.25, -0.04, 
      p = 0.042 and beta = -0.23 (95 % CI: -0.44, -0.01), p = 0.039, respectively]. 
      Generalized linear models showed that exposure versus non-exposure to PYRs with 
      DBCA in infancy increased 4.58 times risk of language development delay (OR = 
      5.58, 95 % CI: 1.76-17.68, p = 0.004) and a 21 % risk of not passing expressive 
      communication items (OR = 1.21, 95 % CI: 1.01-1.45, p = 0.040). The risk of not 
      passing RC items increased 9 % with 4F3PBA increasing per 1 mug/g in infancy (OR = 
      1.09, 95 % CI: 1.02-1.15, p = 0.007). The probability of not passing RC items 
      ascended with infant 4F3PBA (r(s) = 0.57, (95%)CI: 0.48-0.67, p < 0.001). 
      CONCLUSION: Women in the third trimester of pregnancy and their infants were 
      widely exposed to low-dose PYRs. Infant daily exposure to PYRs may negatively 
      impact toddlers' language development, with the 6-8 months age bracket being a 
      sensitive window. The probability of toddlers' language development delay may be 
      predicted by PYRs metabolites of infants aged 6-8 months.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Chen, Shuqi
AU  - Chen S
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Xiao, Xia
AU  - Xiao X
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Qi, Zhiye
AU  - Qi Z
AD  - School of Public Health, Kunming Medical University, Kunming, China; Department 
      of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, 
      Yunnan, China.
FAU - Chen, Lasong
AU  - Chen L
AD  - Reshui Town Health Center, Xuanwei City, Yunnan, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Xu, Lingling
AU  - Xu L
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Zhang, Lili
AU  - Zhang L
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Song, Xiaoxiao
AU  - Song X
AD  - School of Public Health, Kunming Medical University, Kunming, China.
FAU - Li, Yan
AU  - Li Y
AD  - School of Public Health, Kunming Medical University, Kunming, China. Electronic 
      address: yanli20021965@21cn.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220806
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Benzoates)
RN  - 0 (Pesticides)
RN  - 0 (Phenyl Ethers)
RN  - 0 (Pyrethrins)
RN  - 2215-77-2 (4-carboxybiphenyl ether)
RN  - 69DC2655VH (3-phenoxybenzoic acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Benzoates
MH  - Child, Preschool
MH  - China
MH  - Creatinine
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Language Development
MH  - Male
MH  - *Pesticides/toxicity
MH  - Phenyl Ethers
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Prospective Studies
MH  - *Pyrethrins/metabolism/toxicity
OTO - NOTNLM
OT  - Infant
OT  - Language development
OT  - Prenatal
OT  - Pyrethroid pesticides exposure
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/10 06:00
MHDA- 2022/09/21 06:00
CRDT- 2022/08/09 19:35
PHST- 2022/04/14 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/08/10 06:00 [pubmed]
PHST- 2022/09/21 06:00 [medline]
PHST- 2022/08/09 19:35 [entrez]
AID - S0161-813X(22)00125-5 [pii]
AID - 10.1016/j.neuro.2022.08.002 [doi]
PST - ppublish
SO  - Neurotoxicology. 2022 Sep;92:180-190. doi: 10.1016/j.neuro.2022.08.002. Epub 2022 
      Aug 6.