PMID- 35944984
OWN - NLM
STAT- MEDLINE
DCOM- 20220916
LR  - 20221019
IS  - 1349-8029 (Electronic)
IS  - 0470-8105 (Print)
IS  - 0470-8105 (Linking)
VI  - 62
IP  - 9
DP  - 2022 Sep 15
TI  - Histopathological Investigation of Meningioma Capsule with Respect to Tumor Cell 
      Invasion.
PG  - 431-437
LID - 10.2176/jns-nmc.2021-0402 [doi]
AB  - No previous study has histopathologically investigated whether a meningioma 
      capsule presents with tumor cells. We investigated which types of tumor capsules 
      (TCs) included tumor cells to help intraoperatively determine those TCs that do 
      not need to be removed and have a low recurrence risk. We investigated 22 
      specimens of 14 newly diagnosed meningiomas from February 2011 to June 2021. The 
      capsules were classified into three types: TC, capsule-like thickened arachnoid 
      membrane (CAM), and extended membrane (EM). Capsule properties were scored by 
      hardness (soft = 1, medium = 2, hard = 3) and transparency (high = 1, medium = 2, 
      low = 3). The hardness, transparency, and score sums were compared between 
      capsules with and without tumor invasion in the CAM and EM types. The mean 
      follow-up duration was 40.6 months, and there was only one recurrence in a remote 
      location from the residual capsule. Nine capsules were classified as TC, seven as 
      CAM, and six as EM. The tumor cells invaded 88.9% of TCs, 42.9% of CAMs, and 50% 
      of EMs. The hardness, transparency, and score sums for CAMs with tumor invasion 
      were lower than those for CAMs without tumor invasion, although not significant 
      (P = 0.114, P = 0.114, P = 0.057, respectively). A thickened TC or soft and 
      highly transparent CAM indicated a high risk for tumor cell invasion; thus, such 
      cases require a careful and long-term follow-up. Hard and low transparent 
      residual CAMs may have had a low risk for tumor invasion; therefore, leaving such 
      capsules that tightly adhere to the eloquent cortex can be theoretically 
      justified to avoid damaging the brain surface.
FAU - Sugawara, Takashi
AU  - Sugawara T
AD  - Department of Neurosurgery, Tokyo Medical and Dental University.
FAU - Kobayashi, Daisuke
AU  - Kobayashi D
AD  - Department of Human Pathology, Tokyo Medical and Dental University.
FAU - Maehara, Taketoshi
AU  - Maehara T
AD  - Department of Neurosurgery, Tokyo Medical and Dental University.
LA  - eng
PT  - Journal Article
DEP - 20220810
PL  - Japan
TA  - Neurol Med Chir (Tokyo)
JT  - Neurologia medico-chirurgica
JID - 0400775
SB  - IM
MH  - Brain/pathology
MH  - Humans
MH  - *Meningeal Neoplasms/surgery
MH  - *Meningioma/surgery
MH  - Neoplasm Recurrence, Local/pathology
PMC - PMC9534571
OTO - NOTNLM
OT  - capsule
OT  - histopathology
OT  - invasion
OT  - meningioma
OT  - recurrence
COIS- The authors declare that there are no conflicts of interest. All authors who are 
      members of the JNS have registered online the Self-Reported COI Disclosure 
      Statement Forms through the website for JNS members.
EDAT- 2022/08/10 06:00
MHDA- 2022/09/17 06:00
PMCR- 2022/08/10
CRDT- 2022/08/09 21:22
PHST- 2022/08/10 06:00 [pubmed]
PHST- 2022/09/17 06:00 [medline]
PHST- 2022/08/09 21:22 [entrez]
PHST- 2022/08/10 00:00 [pmc-release]
AID - 10.2176/jns-nmc.2021-0402 [doi]
PST - ppublish
SO  - Neurol Med Chir (Tokyo). 2022 Sep 15;62(9):431-437. doi: 
      10.2176/jns-nmc.2021-0402. Epub 2022 Aug 10.