PMID- 35945530
OWN - NLM
STAT- MEDLINE
DCOM- 20220811
LR  - 20220813
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Aug 9
TI  - Concurrence of IgG4-related disease and Kimura disease with pulmonary embolism 
      and lung cancer: a case report.
PG  - 305
LID - 10.1186/s12890-022-02094-9 [doi]
LID - 305
AB  - BACKGROUND: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic 
      disease that involves the infiltration of IgG4-positive plasma cells in multiple 
      organs. Kimura disease (KD) presents as subcutaneous masses on the head and neck, 
      frequently accompanied by eosinophilia and high immunoglobulin E (IgE) levels. 
      Here, we report a rare case of concurrence of IgG4-RD and KD with manifestations 
      of asthma, pulmonary embolism, and central diabetes insipidus accompanied by lung 
      carcinoma. CASE PRESENTATION: A 65-year-old Chinese male with an eight-year 
      history of KD was admitted to our hospital with complaints of dyspnea and 
      expectoration for one month. Laboratory examination showed a considerable 
      elevation in the serum eosinophil count and total IgE and IgG4 levels. Chest 
      enhanced computed tomography showed filling defects in the right pulmonary artery 
      and a nodule in the left inferior lobe. Pancreatic enhanced magnetic resonance 
      imaging (MRI) and magnetic resonance cholangiopancreatography showed a swollen 
      pancreatic tail and local stricture of the pancreatic duct section of the common 
      bile duct. Enhanced MRI of the pituitary gland showed thickening of the pituitary 
      stalk. Additionally, immunohistochemistry of the specimens collected eight years 
      prior revealed IgG4-positive cells. Following the diagnosis of IgG4-RD with KD, 
      glucocorticoids with immunosuppressants were initiated; there was a prompt 
      improvement in the patient's condition. One-year post-discharge, the patient 
      underwent wedge-shaped resection of the lung due to enlargement of the pulmonary 
      nodule, and the pathology revealed lung squamous carcinoma. CONCLUSIONS: This 
      case presents a rare clinical condition in which the concurrence of IgG4-RD and 
      KD causes various rare manifestations including asthma, pulmonary embolism, 
      central diabetes insipidus, and complicated lung carcinoma. This highlights the 
      importance of monitoring for malignancies in IgG4-RD patients during follow-up.
CI  - (c) 2022. The Author(s).
FAU - Lu, Ye
AU  - Lu Y
AD  - Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China 
      Medical University, Shenyang, China.
FAU - Liu, Junxiu
AU  - Liu J
AD  - Department of Intensive Care Unit, The Fourth People's Hospital of Shenyang, 
      Shenyang, China.
FAU - Yan, Hengyi
AU  - Yan H
AD  - Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China 
      Medical University, Shenyang, China.
FAU - Feng, Wei
AU  - Feng W
AD  - Department of Intensive Care Unit, The Fourth People's Hospital of Shenyang, 
      Shenyang, China.
FAU - Zhao, Li
AU  - Zhao L
AD  - Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China 
      Medical University, Shenyang, China.
FAU - Chen, Yu
AU  - Chen Y
AUID- ORCID: 0000-0001-9767-4797
AD  - Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China 
      Medical University, Shenyang, China. chenyusy@hotmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220809
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aftercare
MH  - Aged
MH  - *Asthma/complications
MH  - *Carcinoma
MH  - *Diabetes Insipidus, Neurogenic/complications
MH  - Humans
MH  - Immunoglobulin E
MH  - Immunoglobulin G
MH  - *Immunoglobulin G4-Related Disease/complications/diagnosis
MH  - *Kimura Disease
MH  - *Lung Neoplasms/complications/diagnosis
MH  - Male
MH  - Patient Discharge
MH  - *Pulmonary Embolism/complications
PMC - PMC9361620
OTO - NOTNLM
OT  - Asthma
OT  - Central diabetes insipidus
OT  - IgG4-related disease
OT  - Kimura disease
OT  - Lung squamous carcinoma
OT  - Pulmonary embolism
COIS- The authors declare that they have no competing interests.
EDAT- 2022/08/10 06:00
MHDA- 2022/08/12 06:00
PMCR- 2022/08/09
CRDT- 2022/08/09 23:36
PHST- 2022/03/22 00:00 [received]
PHST- 2022/07/29 00:00 [accepted]
PHST- 2022/08/09 23:36 [entrez]
PHST- 2022/08/10 06:00 [pubmed]
PHST- 2022/08/12 06:00 [medline]
PHST- 2022/08/09 00:00 [pmc-release]
AID - 10.1186/s12890-022-02094-9 [pii]
AID - 2094 [pii]
AID - 10.1186/s12890-022-02094-9 [doi]
PST - epublish
SO  - BMC Pulm Med. 2022 Aug 9;22(1):305. doi: 10.1186/s12890-022-02094-9.