PMID- 35947072
OWN - NLM
STAT- MEDLINE
DCOM- 20220901
LR  - 20230930
IS  - 1535-1815 (Electronic)
IS  - 0749-5161 (Linking)
VI  - 38
IP  - 9
DP  - 2022 Sep 1
TI  - Benzodiazepine Use for Pediatric Patients With Suspected Nonconvulsive Status 
      Epilepticus With or Without Simplified Electroencephalogram: A Retrospective 
      Cohort Study.
PG  - e1545-e1551
LID - 10.1097/PEC.0000000000002811 [doi]
AB  - OBJECTIVES: In the present study, we aimed to determine the changes in the 
      administration rate of benzodiazepines for pediatric patients with suspected 
      nonconvulsive status epilepticus (NCSE) before and after the introduction of 
      simplified electroencephalography (sEEG) in the emergency department. METHODS: 
      This retrospective cohort study included patients who were younger than 18 years 
      and were admitted to the emergency department from August 1, 2009, to July 31, 
      2017, with altered level of consciousness and nonpurposeful movement of eyes or 
      extremities after the cessation of convulsive status epilepticus. Patients with 
      apparent persistent convulsions, those who were fully conscious on arrival, and 
      those who were transferred from another hospital were excluded. The patients were 
      categorized into pre and post groups based on the introduction of sEEG, and 
      benzodiazepine administration was compared between the 2 groups. RESULTS: During 
      the study period, 464 patients with status epilepticus visited our emergency 
      department and 69 and 93 patients fulfilling the study criteria were categorized 
      into the pre and post groups, respectively. There were no significant differences 
      in patient background characteristics between the 2 groups. Simplified 
      electroencephalography was recorded in 52 patients in the post group. 
      Benzodiazepines were administered in 44 of 69 patients (63.8%) in the pre group 
      and 44 of 93 (47.3%) in the post group, and the benzodiazepine administration 
      rate was significantly decreased after the introduction of sEEG ( P = 0.04). The 
      hospitalization rate was significantly lower in the post group, but there were no 
      significant differences in the rates of intensive care unit admission, 
      reconvulsion after discharge, and final diagnoses between the 2 groups. 
      CONCLUSIONS: Simplified electroencephalography might aid in determining the need 
      for anticonvulsant treatment for suspected NCSE in pediatric patients. Albeit not 
      a definitive diagnostic tool, sEEG might be a reliable choice in the evaluation 
      of pediatric patients with suspected NCSE.
CI  - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Takase, Ryo
AU  - Takase R
AD  - From the Department of Pediatric Emergency and Transport Services.
FAU - Sasaki, Ryuji
AU  - Sasaki R
AD  - From the Department of Pediatric Emergency and Transport Services.
FAU - Tsuji, Satoshi
AU  - Tsuji S
AD  - From the Department of Pediatric Emergency and Transport Services.
FAU - Uematsu, Satoko
AU  - Uematsu S
AD  - From the Department of Pediatric Emergency and Transport Services.
FAU - Kubota, Mitsuru
AU  - Kubota M
AD  - Interdisciplinary Pediatrics.
FAU - Kobayashi, Tohru
AU  - Kobayashi T
AD  - Department of Data Science, Clinical Research Center, National Center for Child 
      Health and Development, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220809
PL  - United States
TA  - Pediatr Emerg Care
JT  - Pediatric emergency care
JID - 8507560
RN  - 12794-10-4 (Benzodiazepines)
SB  - IM
MH  - *Benzodiazepines/therapeutic use
MH  - Child
MH  - Electroencephalography
MH  - Humans
MH  - Retrospective Studies
MH  - Seizures
MH  - *Status Epilepticus/diagnosis/drug therapy
COIS- Disclosure: The authors declare no conflict of interest.
EDAT- 2022/08/11 06:00
MHDA- 2022/09/02 06:00
CRDT- 2022/08/10 10:33
PHST- 2022/08/11 06:00 [pubmed]
PHST- 2022/09/02 06:00 [medline]
PHST- 2022/08/10 10:33 [entrez]
AID - 00006565-202209000-00025 [pii]
AID - 10.1097/PEC.0000000000002811 [doi]
PST - ppublish
SO  - Pediatr Emerg Care. 2022 Sep 1;38(9):e1545-e1551. doi: 
      10.1097/PEC.0000000000002811. Epub 2022 Aug 9.