PMID- 35947833
OWN - NLM
STAT- MEDLINE
DCOM- 20220812
LR  - 20220822
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 37
IP  - 1
DP  - 2022 Jun 30
TI  - A novel gedunin-2-hydroxypropyl-beta-cyclodextrin inclusion complex improves 
      anti-nociceptive and anti-inflammatory activities of gedunin in rodents.
PG  - 9-19
LID - 10.54548/njps.v37i1.2 [doi]
AB  - Gedunin is a bioactive compound, obtained from Entandrophragma angolense (EA), 
      which has limited therapeutic usefulness due to poor aqueous solubility and 
      first-pass effects. Cyclodextrins are cyclic oligosaccharides that form complexes 
      with poorly soluble compounds, thus enhancing their pharmacological activity. In 
      this article, we evaluated the pharmacological activities of 
      gedunin-2-hydroxypropyl-beta-cyclodextrin complex (GCD) in rodents. The 
      antinociceptive activity of GCD (50, 100, 200 mg/kg) and Gedunin (50mg/kg) was 
      tested in acetic acid-induced writhing and formalin-induced paw licking in mice. 
      The anti-inflammatory activity was investigated in carrageenan-induced paw oedema 
      and air pouch inflammation models in rats. Leucocytes counts, Tumour Necrosis 
      Factor-alpha (TNF-alpha) level, nitric oxide, malondialdehyde, reduced glutathione, 
      and myeloperoxidase enzyme activities were assessed in the air pouch exudate. The 
      GCD (200mg/kg) significantly decreased writhing response, reduced licking 
      duration and decreased oedema compared with gedunin and control. Exudate volume 
      and leucocyte count were significantly reduced by GCD (200 mg/kg), it decreased 
      myeloperoxidase activity and inhibited TNF-alpha release. The carrageenan-induced GSH 
      depletion, increased malondialdehyde and nitrite levels were significantly 
      reversed by GCD (200 mg/kg) relative to gedunin and control.  The GCD complex 
      demonstrated significant antinociceptive and anti-inflammatory activities 
      relative to gedunin alone via mechanisms associated with inhibition of oxidative 
      stress and inflammation in rodents.
FAU - Ologe, Mary Olufunmilayo
AU  - Ologe MO
AD  - University of Ilorin, Ilorin. funmiologe@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20220630
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the 
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Limonins)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
RN  - 2753-30-2 (gedunin)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9000-07-1 (Carrageenan)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - 2-Hydroxypropyl-beta-cyclodextrin
MH  - *Analgesics/pharmacology/therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Antioxidants/therapeutic use
MH  - Carrageenan
MH  - Edema/chemically induced/drug therapy
MH  - Inflammation/drug therapy
MH  - Limonins
MH  - Malondialdehyde
MH  - Mice
MH  - Pain/chemically induced/drug therapy
MH  - Peroxidase
MH  - Plant Extracts/pharmacology
MH  - Rats
MH  - Rodentia
MH  - *Tumor Necrosis Factor-alpha
EDAT- 2022/08/11 06:00
MHDA- 2022/08/13 06:00
CRDT- 2022/08/10 16:42
PHST- 2022/05/27 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/08/10 16:42 [entrez]
PHST- 2022/08/11 06:00 [pubmed]
PHST- 2022/08/13 06:00 [medline]
AID - 10.54548/njps.v37i1.2 [doi]
PST - epublish
SO  - Niger J Physiol Sci. 2022 Jun 30;37(1):9-19. doi: 10.54548/njps.v37i1.2.