PMID- 35952778
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221007
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 435
DP  - 2022 Oct 28
TI  - N-Ethylnorketamine has anesthetic and analgesic effects with abuse liability.
PG  - 114052
LID - S0166-4328(22)00320-5 [pii]
LID - 10.1016/j.bbr.2022.114052 [doi]
AB  - Arylcyclohexylamines is an ever-growing class of new psychoactive substances, 
      including an increasing number of ketamine analogs. N-Ethylnorketamine (NENK) is 
      a new synthetic ketamine analog that has emerged as an abused drug, but little is 
      known about the pharmacological profile of NENK. In this study, we investigated 
      the anesthetic and analgesic activity, abuse liability of NENK compared with 
      ketamine. The ED(50) values of anesthetic activity for NENK and ketamine were 
      96.9, 69.4 mg/kg, respectively. The ED(50) values of analgesic activity for NENK 
      and ketamine were 45.9 and 23.6 mg/kg, respectively. NENK induced significant 
      conditioned place preference at a minimum dose of 10.0 mg/kg in mice, an effect 
      comparable to that of ketamine (3.0 mg/kg). Acute injections of NENK or ketamine 
      at 30.0 mg/kg enhanced locomotor activity, and repeated treatments with this dose 
      induced locomotor sensitization after withdrawal. Taken together, these results 
      clearly demonstrated that NENK has lower anesthetic and analgesic activity 
      compared to ketamine, but has significant abuse liability.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Li, Feng
AU  - Li F
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China.
FAU - Qiao, Yanling
AU  - Qiao Y
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China; Key Laboratory of Drug Monitoring and Control, 
      Drug Intelligence and Forensic Center, Ministry of Public Security, Beijing 
      100193, PR China.
FAU - Chen, Yuanyuan
AU  - Chen Y
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China.
FAU - Li, Nan
AU  - Li N
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China.
FAU - Yang, Mengxiang
AU  - Yang M
AD  - Faculty of Physiology & Pharmacology, School of Medicine, Ningbo University, 
      Ningbo 315211, Zhejiang, PR China.
FAU - Li, Xiangyu
AU  - Li X
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China; Key Laboratory of Drug Monitoring and Control, 
      Drug Intelligence and Forensic Center, Ministry of Public Security, Beijing 
      100193, PR China.
FAU - Qiu, Yi
AU  - Qiu Y
AD  - National Institute on Drug Dependence, Peking University, Beijing 100191, PR 
      China.
FAU - Cui, Wei
AU  - Cui W
AD  - Faculty of Physiology & Pharmacology, School of Medicine, Ningbo University, 
      Ningbo 315211, Zhejiang, PR China.
FAU - Shen, Haowei
AU  - Shen H
AD  - Faculty of Physiology & Pharmacology, School of Medicine, Ningbo University, 
      Ningbo 315211, Zhejiang, PR China.
FAU - Xu, Peng
AU  - Xu P
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China; Key Laboratory of Drug Monitoring and Control, 
      Drug Intelligence and Forensic Center, Ministry of Public Security, Beijing 
      100193, PR China. Electronic address: pengxu750@163.com.
FAU - Di, Bin
AU  - Di B
AD  - School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, PR 
      China; Office of China National Narcotics Control Commission, China 
      Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics 
      Control, Beijing 100193, PR China. Electronic address: dibin@cpu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220808
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Anesthetics)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - *Anesthetics
MH  - Animals
MH  - *Ketamine/pharmacology
MH  - Mice
OTO - NOTNLM
OT  - Abuse liability
OT  - Analgesia
OT  - Anesthesia
OT  - Ketamine
OT  - N-Ethylnorketamine
COIS- Declaration of competing interest The authors declare that they have no conflict 
      of interest.
EDAT- 2022/08/12 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/11 19:33
PHST- 2022/04/20 00:00 [received]
PHST- 2022/07/13 00:00 [revised]
PHST- 2022/08/07 00:00 [accepted]
PHST- 2022/08/12 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/11 19:33 [entrez]
AID - S0166-4328(22)00320-5 [pii]
AID - 10.1016/j.bbr.2022.114052 [doi]
PST - ppublish
SO  - Behav Brain Res. 2022 Oct 28;435:114052. doi: 10.1016/j.bbr.2022.114052. Epub 
      2022 Aug 8.