PMID- 3595321
OWN - NLM
STAT- MEDLINE
DCOM- 19870817
LR  - 20190903
IS  - 0300-5208 (Print)
IS  - 0300-5208 (Linking)
VI  - 127
DP  - 1987
TI  - Humoral immune responses in human onchocerciasis: detection of serum antibodies 
      in early infections.
PG  - 180-8
AB  - Sera of children (aged 1-15 years) living in a hyperendemic onchocerciasis area 
      (Mali) were tested for antibodies by an enzyme-linked immunosorbent assay (ELISA) 
      and a radioallergosorbent test (RAST), with an extract of adult Onchocerca 
      volvulus as antigen. Serological results were related to age (equivalent to time 
      of residence in the endemic area) and to parasitological findings (detection of 
      skin microfilariae). This longitudinal study (over three years) allowed us to 
      follow early antibody responses in exposed children with no parasitological or 
      clinical evidence of infection and in children who became microfilaria-positive. 
      Serum antibodies against O. volvulus could be detected one to three years before 
      skin microfilariae. RAST, which detected circulating immunoglobulin E (IgE) 
      antibodies, was more sensitive than ELISA in prepatent infections and gave more 
      positive results for exposed but parasitologically negative individuals than did 
      ELISA. During patent infection, IgE antibody levels tended to decrease in about 
      half those infected, whereas in most children non-IgE antibodies showed no 
      significant changes.
FAU - Weiss, N
AU  - Weiss N
FAU - Karam, M
AU  - Karam M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ciba Found Symp
JT  - Ciba Foundation symposium
JID - 0356636
RN  - 0 (Antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Antibodies/*analysis
MH  - Antibody Formation
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoglobulin E/*analysis/biosynthesis
MH  - Infant
MH  - Longitudinal Studies
MH  - Microfilariae/immunology
MH  - Onchocerca/*immunology
MH  - Onchocerciasis/*immunology
MH  - Radioallergosorbent Test
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1002/9780470513446.ch12 [doi]
PST - ppublish
SO  - Ciba Found Symp. 1987;127:180-8. doi: 10.1002/9780470513446.ch12.