PMID- 35953577
OWN - NLM
STAT- MEDLINE
DCOM- 20230208
LR  - 20230208
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 43
IP  - 1
DP  - 2023 Jan
TI  - Evaluation of optical coherence tomography findings and visual evoked potentials 
      in Charcot-Marie-Tooth disease.
PG  - 333-341
LID - 10.1007/s10792-022-02452-w [doi]
AB  - PURPOSE: To evaluate the spectral-domain optical coherence tomography (SD-OCT) 
      findings and pattern visual evoked potential (VEP) in Charcot-Marie-Tooth (CMT) 
      disease. METHODS: Seventeen patients with CMT disease and 17 control subjects 
      were included in the study. The patients were divided into two groups according 
      to conduction velocity and inheritance pattern as demyelinating type (CMT 1) and 
      axonal type (CMT 2). The average retinal nerve fiber layer (RNFL) thickness, RNFL 
      thicknesses of all quadrants, and thicknesses of the ganglion cell layer complex 
      (GCC) were measured using SD-OCT. Pattern VEP recordings were evaluated in both 
      groups. RESULTS: The average and four quadrants of RNFL thicknesses, and superior 
      and inferior GCC thicknesses were significantly thinner in the CMT patients 
      compared with healthy individuals, but there were no statistically significant 
      differences between the CMT groups. There was a significant positive correlation 
      between age and all RNFL and GCC thicknesses in the CMT 2 group and between age 
      and RNFL thickness of the temporal quadrant in the CMT 1 group. P100 latencies 
      were significantly delayed in the CMT groups compared with controls, and there 
      were no significant differences in P100 latencies between the CMT groups 
      (p < 0.001). VEP amplitudes were in normal ranges in the CMT groups. CONCLUSION: 
      This study showed that RNFL and GCC thicknesses were significantly reduced and 
      VEP latencies were prolonged in patients with CMT with normal clinical 
      examinations. Our results suggest that optic nerves may be affected more 
      frequently in patients with CMT that is detected in clinical examinations.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Kaplan, Aysin Tuba
AU  - Kaplan AT
AUID- ORCID: 0000-0003-0793-5530
AD  - Ophthalmology Department, Kartal Dr. Lutfi Kirdar City Hospital, 34865, Istanbul, 
      Kartal, Turkey. aysintuba@yahoo.com.
FAU - Oskan Yalcin, Sibel
AU  - Oskan Yalcin S
AUID- ORCID: 0000-0002-1075-483X
AD  - Ophthalmology Department, Kartal Dr. Lutfi Kirdar City Hospital, 34865, Istanbul, 
      Kartal, Turkey.
FAU - Sager, Safiye Gunes
AU  - Sager SG
AUID- ORCID: 0000-0002-9876-2454
AD  - Pediatric Neurology Department, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, 
      Turkey.
FAU - Turkyilmaz, Ayberk
AU  - Turkyilmaz A
AUID- ORCID: 0000-0001-9647-8970
AD  - Faculty of Medicine, Medical Genetics Department, Karadeniz Technical University, 
      Trabzon, Turkey.
FAU - Inan, Rahsan
AU  - Inan R
AUID- ORCID: 0000-0002-6084-055X
AD  - Neurology Department, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220812
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
SB  - IM
MH  - Humans
MH  - *Evoked Potentials, Visual
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence/methods
MH  - *Charcot-Marie-Tooth Disease/diagnosis
MH  - Retina
OTO - NOTNLM
OT  - Axonal type
OT  - Demyelinating
OT  - Ganglion cell
OT  - Latency
OT  - Retinal nerve fiber layer
EDAT- 2022/08/12 06:00
MHDA- 2023/02/09 06:00
CRDT- 2022/08/11 23:22
PHST- 2022/01/11 00:00 [received]
PHST- 2022/07/31 00:00 [accepted]
PHST- 2022/08/12 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2022/08/11 23:22 [entrez]
AID - 10.1007/s10792-022-02452-w [pii]
AID - 10.1007/s10792-022-02452-w [doi]
PST - ppublish
SO  - Int Ophthalmol. 2023 Jan;43(1):333-341. doi: 10.1007/s10792-022-02452-w. Epub 
      2022 Aug 12.