PMID- 35955225
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220815
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 15
IP  - 15
DP  - 2022 Jul 31
TI  - Drug Delivery Systems with a "Tumor-Triggered" Targeting or Intracellular Drug 
      Release Property Based on DePEGylation.
LID - 10.3390/ma15155290 [doi]
LID - 5290
AB  - Coating nanosized anticancer drug delivery systems (DDSs) with poly(ethylene 
      glycol) (PEG), the so-called PEGylation, has been proven an effective method to 
      enhance hydrophilicity, aqueous dispersivity, and stability of DDSs. What is 
      more, as PEG has the lowest level of protein absorption of any known polymer, 
      PEGylation can reduce the clearance of DDSs by the mononuclear phagocyte system 
      (MPS) and prolong their blood circulation time in vivo. However, the "stealthy" 
      characteristic of PEG also diminishes the uptake of DDSs by cancer cells, which 
      may reduce drug utilization. Therefore, dynamic protection strategies have been 
      widely researched in the past years. Coating DDSs with PEG through dynamic 
      covalent or noncovalent bonds that are stable in blood and normal tissues, but 
      can be broken in the tumor microenvironment (TME), can achieve a 
      DePEGylation-based "tumor-triggered" targeting or intracellular drug release, 
      which can effectively improve the utilization of drugs and reduce their side 
      effects. In this review, the stimuli and methods of "tumor-triggered" targeting 
      or intracellular drug release, based on DePEGylation, are summarized. 
      Additionally, the targeting and intracellular controlled release behaviors of the 
      DDSs are briefly introduced.
FAU - Ren, Zhe
AU  - Ren Z
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Liao, Tao
AU  - Liao T
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Li, Cao
AU  - Li C
AUID- ORCID: 0000-0002-3500-340X
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Kuang, Ying
AU  - Kuang Y
AD  - National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key 
      Laboratory of Fermentation Engineering (Ministry of Education), Hubei University 
      of Technology, Wuhan 430068, China.
LA  - eng
GR  - XBTK-2022006/HBUT National "111" Center for Cellular Regulation and 
      Molecular Pharmaceutics 2022 Collaborative Grant/
PT  - Journal Article
PT  - Review
DEP - 20220731
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC9369796
OTO - NOTNLM
OT  - DePEGylationg
OT  - controlled release
OT  - dynamic protection strategy
OT  - tumor-triggered targeting
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/13 06:01
PMCR- 2022/07/31
CRDT- 2022/08/12 01:10
PHST- 2022/06/23 00:00 [received]
PHST- 2022/07/27 00:00 [revised]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/12 01:10 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/13 06:01 [medline]
PHST- 2022/07/31 00:00 [pmc-release]
AID - ma15155290 [pii]
AID - materials-15-05290 [pii]
AID - 10.3390/ma15155290 [doi]
PST - epublish
SO  - Materials (Basel). 2022 Jul 31;15(15):5290. doi: 10.3390/ma15155290.