PMID- 35956020 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 15 DP - 2022 Jul 28 TI - Associations of Chronic Diabetes Complications and Cardiovascular Risk with the Risk of Obstructive Sleep Apnea in Patients with Type 2 Diabetes. LID - 10.3390/jcm11154403 [doi] LID - 4403 AB - Background: Type 2 diabetes mellitus (T2DM) is associated with increased mortality and morbidity, including cardiovascular diseases and obstructive sleep apnea (OSA). The aim of this study was to assess the associations between cardiovascular risk, chronic diabetes complications and the risk of OSA in adult patients with T2DM. Methods: The study included 529 patients with T2DM in whom moderate-to-severe OSA risk was assessed using the STOP-Bang questionnaire, dividing the subjects into two groups: group 1: STOP-Bang score <5, and group 2: STOP-Bang score >/=5, respectively. In all the subjects, cardiovascular risk was assessed using the UKPDS risk engine. Statistical analysis was performed using SPSS 26.0, the results being statistically significant if p value was <0.05. Results: 59% of the subjects scored >/=5 on the STOP-Bang questionnaire. We recorded statistically significant differences between the two groups regarding diabetes duration, HbA1c, HOMA-IR, albuminuria, as well as cardiovascular risk at 10 years for both coronary heart disease (CHD) and stroke (p < 0.05). Furthermore, through logistic regression, adjusting for confounding factors, we demonstrated that the STOP-Bang score >/= 5 is a risk factor for 10-year fatal and nonfatal CHD risk. Conclusions: It is extremely important to screen and diagnose OSA in patients with T2DM, in order to improve the primary and secondary prevention of cardiovascular events in these patients. FAU - Protasiewicz Timofticiuc, Diana Cristina AU - Protasiewicz Timofticiuc DC AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Diabetes, Nutrition and Metabolic Diseases, County Clinical Emergency Hospital of Craiova, 200642 Craiova, Romania. FAU - Vladu, Ionela Mihaela AU - Vladu IM AD - Department of Diabetes, Nutrition and Metabolic Diseases, County Clinical Emergency Hospital of Craiova, 200642 Craiova, Romania. AD - Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Stefan, Adela-Gabriela AU - Stefan AG AD - Calafat Municipal Hospital, 205200 Calafat, Romania. FAU - Clenciu, Diana AU - Clenciu D AUID- ORCID: 0000-0002-5832-0715 AD - Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Diabetes, Nutrition and Metabolic Diseases, Clinical Municipal Hospital "Philanthropy" of Craiova, 200143 Craiova, Romania. FAU - Mitrea, Adina AU - Mitrea A AUID- ORCID: 0000-0002-5310-3033 AD - Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Diabetes, Nutrition and Metabolic Diseases, Clinical Municipal Hospital "Philanthropy" of Craiova, 200143 Craiova, Romania. FAU - Padureanu, Vlad AU - Padureanu V AUID- ORCID: 0000-0001-7398-5689 AD - Department of Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Internal Medicine, County Clinical Emergency Hospital of Craiova, 200642 Craiova, Romania. FAU - Efrem, Ion Cristian AU - Efrem IC AD - Department of Internal Medicine and Medical Semiology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Internal Medicine, Clinical Municipal Hospital "Philanthropy" of Craiova, 200143 Craiova, Romania. FAU - Diaconu, Ileana-Diana AU - Diaconu ID AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Pediatric Pneumology, "Marius Nasta" National Institute of Pneumophtisiology, 050159 Bucharest, Romania. FAU - Turcu, Adina AU - Turcu A AD - Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Infectious Diseases Hospital "Victor Babes", 200515 Craiova, Romania. FAU - Tenea-Cojan, Tiberiu Stefanita AU - Tenea-Cojan TS AD - Department of General Surgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of General Surgery, C.F. Clinical Hospital, 200374 Craiova, Romania. FAU - Hancu, Anca Mihaela AU - Hancu AM AD - Nutriscience Clinic, 011761 Bucharest, Romania. FAU - Fortofoiu, Maria AU - Fortofoiu M AUID- ORCID: 0000-0002-2056-6779 AD - Department of Emergency Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Emergency Medicine, Clinical Municipal Hospital "Philanthropy" of Craiova, 200143 Craiova, Romania. FAU - Mirea Munteanu, Oana AU - Mirea Munteanu O AD - Department of Cardiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Cardiology, County Clinical Emergency Hospital of Craiova, 200642 Craiova, Romania. FAU - Mota, Maria AU - Mota M AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. LA - eng PT - Journal Article DEP - 20220728 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9368962 OTO - NOTNLM OT - STOP-Bang score OT - cardiovascular risk OT - obstructive sleep apnea OT - type 2 diabetes COIS- The authors declare no conflict of interest. EDAT- 2022/08/13 06:00 MHDA- 2022/08/13 06:01 PMCR- 2022/07/28 CRDT- 2022/08/12 01:15 PHST- 2022/06/13 00:00 [received] PHST- 2022/07/01 00:00 [revised] PHST- 2022/07/26 00:00 [accepted] PHST- 2022/08/12 01:15 [entrez] PHST- 2022/08/13 06:00 [pubmed] PHST- 2022/08/13 06:01 [medline] PHST- 2022/07/28 00:00 [pmc-release] AID - jcm11154403 [pii] AID - jcm-11-04403 [pii] AID - 10.3390/jcm11154403 [doi] PST - epublish SO - J Clin Med. 2022 Jul 28;11(15):4403. doi: 10.3390/jcm11154403.