PMID- 35956134
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 15
DP  - 2022 Aug 3
TI  - Effect of Influenza Vaccination on the Reduction of the Incidence of Chronic 
      Kidney Disease and Dialysis in Patients with Type 2 Diabetes Mellitus.
LID - 10.3390/jcm11154520 [doi]
LID - 4520
AB  - Patients with type 2 diabetes mellitus (T2DM) have a higher risk of chronic 
      kidney disease (CKD) due to vascular complications and chronic inflammation. T2DM 
      contributes to a higher risk of mortality and morbidity related to influenza. In 
      Taiwan, influenza vaccination is recommended for patients with T2DM. A previous 
      meta-analysis reported the efficacy of influenza vaccination in reducing 
      hospitalization and mortality in patients with diabetes; however, the renal 
      protective effect of the vaccine remains unclear. This study evaluated whether 
      influenza vaccination could reduce the incidence of CKD and dialysis in patients 
      with T2DM. The study cohort included all patients aged >/=55 years who were 
      diagnosed as having T2DM between 1 January 2000 and 31 December 2012, by using 
      data from Taiwan's National Health Insurance Research Database. Each patient was 
      followed up with to assess factors associated with CKD. A time-dependent Cox 
      proportional hazard regression model after adjustment for potential confounders 
      was used to calculate the hazard ratio (HR) of CKD in the vaccinated and 
      unvaccinated patients. The study population comprised 48,017 eligible patients 
      with DM; 23,839 (49.7%) received influenza vaccination and the remaining 24,178 
      (50.3%) did not. The adjusted HRs (aHRs) for CKD/dialysis decreased in the 
      vaccinated patients compared with the unvaccinated patients (influenza season, 
      noninfluenza season, and all seasons: aHRs: 0.47/0.47, 0.48/0.49, and 0.48/0.48, 
      respectively, all p < 0.0001). We observed similar protective effects against CKD 
      during the influenza and noninfluenza seasons. Regardless of comorbidities or 
      drug use, influenza vaccination was an independent protective factor. 
      Furthermore, aHRs for CKD/dialysis were 0.71 (0.65-0.77)/0.77 (0.68-0.87), 0.57 
      (0.52-0.61)/0.69 (0.56-0.70), and 0.30 (0.28-0.33)/0.28 (0.24-0.31) in the 
      patients who received 1, 2-3, and >/=4 vaccinations during the follow-up period, 
      respectively. This population-based cohort study demonstrated that influenza 
      vaccination exerts a dose-dependent and synergistic protective effect against CKD 
      in the patients with T2DM with associated risk factors.
FAU - Sung, Li-Chin
AU  - Sung LC
AUID- ORCID: 0000-0001-6292-7117
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
AD  - Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical 
      University, New Taipei City 235, Taiwan.
FAU - Chen, Chun-Chao
AU  - Chen CC
AUID- ORCID: 0000-0002-4888-3709
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
AD  - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical 
      University, Taipei 110, Taiwan.
FAU - Liu, Shih-Hao
AU  - Liu SH
AD  - Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical 
      University, New Taipei City 235, Taiwan.
FAU - Chiu, Chun-Chih
AU  - Chiu CC
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
FAU - Yang, Tsung-Yeh
AU  - Yang TY
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
FAU - Lin, Cheng-Hsin
AU  - Lin CH
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
AD  - Division of Cardiovascular Surgery, Department of Surgery, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Division of Cardiovascular Surgery, Department of Surgery, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
FAU - Fan, Yu-Ann
AU  - Fan YA
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
FAU - Jian, William
AU  - Jian W
AD  - Department of Emergency, University Hospitals Cleveland Medical Center, 
      Cleveland, OH 44106, USA.
FAU - Lei, Meng-Huan
AU  - Lei MH
AD  - Cardiovascular Center, Lo-Hsu Medical Foundation Luodong Poh-Ai Hospital, Yilan 
      265, Taiwan.
FAU - Yeh, Hsien-Tang
AU  - Yeh HT
AUID- ORCID: 0000-0003-2602-6463
AD  - Department of Surgery, Lotung Poh-Ai Hospital, Luodong 265, Taiwan.
FAU - Hsu, Min-Huei
AU  - Hsu MH
AD  - Graduate Institute of Data Science, College of Management, Taipei Medical 
      University, Taipei 110, Taiwan.
AD  - Department of Neurosurgery, Wan-Fang Hospital, Taipei Medical University, Taipei 
      110, Taiwan.
FAU - Hao, Wen-Rui
AU  - Hao WR
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
FAU - Liu, Ju-Chi
AU  - Liu JC
AD  - Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, 
      Taipei Medical University, New Taipei City 235, Taiwan.
AD  - Taipei Heart Institute, Taipei Medical University, Taipei 110, Taiwan.
AD  - Division of Cardiology, Department of Internal Medicine, School of Medicine, 
      College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
LA  - eng
GR  - 111-TMU085/Higher Education Sprout Project by the Ministry of Education (MOE) in 
      Taiwan and Taipei Medical University-National Taiwan University Hospital Joint 
      Research Program/
PT  - Journal Article
DEP - 20220803
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9369464
OTO - NOTNLM
OT  - chronic kidney disease
OT  - cohort studies
OT  - diabetes mellitus
OT  - influenza vaccines
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/13 06:01
PMCR- 2022/08/03
CRDT- 2022/08/12 01:15
PHST- 2022/07/05 00:00 [received]
PHST- 2022/07/31 00:00 [revised]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/08/12 01:15 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/13 06:01 [medline]
PHST- 2022/08/03 00:00 [pmc-release]
AID - jcm11154520 [pii]
AID - jcm-11-04520 [pii]
AID - 10.3390/jcm11154520 [doi]
PST - epublish
SO  - J Clin Med. 2022 Aug 3;11(15):4520. doi: 10.3390/jcm11154520.