PMID- 35956364 OWN - NLM STAT- MEDLINE DCOM- 20220815 LR - 20220815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 14 IP - 15 DP - 2022 Aug 3 TI - Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study. LID - 10.3390/nu14153186 [doi] LID - 3186 AB - Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiological relationship with NAFLD. To assess the effect of adherence to a MedDiet on NAFLD in MetS patients after lifestyle intervention, this multicentre (Mallorca and Navarra, Spain) prospective randomized trial, with personalized nutritional intervention based on a customized MedDiet, coupled with physical activity promotion was performed to prevent, and reverse NAFLD among patients with MetS. The current analysis included 138 patients aged 40 to 60 years old, Body Mass Index (BMI) 27-40 kg/m(2), diagnosed with NAFLD using MRI, and MetS according to the International Diabetes Federation (IDF). A validated food frequency questionnaire was used to assess dietary intake. Adherence to Mediterranean diet by means of a 17-item validated questionnaire, anthropometrics, physical activity, blood pressure, blood biochemical parameters, and intrahepatic fat contents (IFC) were measured. The independent variable used was changes in MedDiet adherence, categorized in tertiles after 6 months follow-up. Subjects with high adherence to the MedDiet showed higher decreases in BMI, body weight, WC, SBP, DBP, and IFC. An association between improvement in adherence to the MedDiet and amelioration of IFC after 6-month follow-up was observed. High adherence to the MedDiet is associated with better status of MetS features, and better values of IFC. FAU - Montemayor, Sofia AU - Montemayor S AUID- ORCID: 0000-0001-7833-2118 AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. FAU - Mascaro, Catalina M AU - Mascaro CM AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. FAU - Ugarriza, Lucia AU - Ugarriza L AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - Camp Redo Primary Health Care Center, 07010 Palma de Mallorca, Spain. FAU - Casares, Miguel AU - Casares M AD - Radiodiagnosis Service, Red Asistencial Juaneda, 07011 Palma de Mallorca, Spain. FAU - Llompart, Isabel AU - Llompart I AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - Clinical Analysis Service, University Hospital Son Espases, 07120 Palma de Mallorca, Spain. FAU - Abete, Itziar AU - Abete I AUID- ORCID: 0000-0002-6475-5387 AD - CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. AD - Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. FAU - Zulet, Maria Angeles AU - Zulet MA AUID- ORCID: 0000-0002-3926-0892 AD - CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. AD - Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. FAU - Martinez, J Alfredo AU - Martinez JA AD - Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. AD - Cardiometabolics Precision Nutrition Program, IMDEA Food, CEI UAM-CSIC, 28049 Madrid, Spain. FAU - Tur, Josep A AU - Tur JA AUID- ORCID: 0000-0002-6940-0761 AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. FAU - Bouzas, Cristina AU - Bouzas C AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain. AD - CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. LA - eng GR - CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03/Instituto de Salud Carlos III/ GR - 201630.10/Fundacio La Marato TV3/ GR - FOLIUM, PRIMUS, SYNERGIA, and LIBERI/IDISBA/ GR - FPU PhD grant/Spanish Ministry of Education/ GR - post-doctoral grant/Directorate General of R+D of the Balearic Islands Government/ PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20220803 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Adult MH - *Diabetes Mellitus, Type 2/complications MH - *Diet, Mediterranean MH - Humans MH - *Metabolic Syndrome/prevention & control MH - Middle Aged MH - *Non-alcoholic Fatty Liver Disease/complications MH - Prospective Studies PMC - PMC9370227 OTO - NOTNLM OT - Mediterranean diet OT - NAFLD OT - intrahepatic fat contents OT - metabolic syndrome OT - non-alcoholic fat liver disease COIS- The authors declare no conflict of interest. EDAT- 2022/08/13 06:00 MHDA- 2022/08/16 06:00 PMCR- 2022/08/03 CRDT- 2022/08/12 01:17 PHST- 2022/07/06 00:00 [received] PHST- 2022/07/25 00:00 [revised] PHST- 2022/08/02 00:00 [accepted] PHST- 2022/08/12 01:17 [entrez] PHST- 2022/08/13 06:00 [pubmed] PHST- 2022/08/16 06:00 [medline] PHST- 2022/08/03 00:00 [pmc-release] AID - nu14153186 [pii] AID - nutrients-14-03186 [pii] AID - 10.3390/nu14153186 [doi] PST - epublish SO - Nutrients. 2022 Aug 3;14(15):3186. doi: 10.3390/nu14153186.