PMID- 35957718
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220813
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 10
IP  - 13
DP  - 2022 Jul
TI  - Clinicopathological features and prognosis of bilateral breast cancer: a 
      single-center cohort study based on Chinese data.
PG  - 742
LID - 10.21037/atm-21-5400 [doi]
LID - 742
AB  - BACKGROUND: The incidence of bilateral breast cancer (BBC) is low, accounting for 
      5% of patients with breast cancer. This study aimed to investigate the 
      clinicopathological features and prognosis of synchronous bilateral breast cancer 
      (SBBC) and metachronous bilateral breast cancer (MBBC) in the Chinese population. 
      METHODS: Patients with BBC, including SBBC and MBBC, were selected from 6,162 
      breast cancer patients who underwent surgery at the Chinese People's Liberation 
      Army (PLA) General Hospital between January 2007 and December 2019. Furthermore, 
      patients with unilateral breast cancer (UBC) who underwent surgery at the same 
      time were randomly selected at a ratio of 1:2 as the control group. 
      Clinicopathological features and prognosis were compared between the groups. 
      RESULTS: In all, 123 (2.0%) patients with BBC were enrolled in this study, 
      including 98 (1.6%) SBBC and 25 (0.4%) MBBC patients. A total of 280 patients 
      with UBC were selected for the control group. Compared with patients with UBC, 
      patients with SBBC were more likely to be older and have a family history of 
      breast cancer, non-infiltrative carcinoma, lower pathological 
      tumor-node-metastasis (pTNM) stage, and luminal A type breast cancer as their 
      first tumor. Patients with MBBC were more likely to be postmenopausal and have 
      hormone receptor [estrogen receptor (ER)/progesterone receptor (PR)] negativity, 
      a higher pTNM stage, and a triple-negative first tumor. Patients with UBC with 
      ER/PR (-) were more likely to develop contralateral breast cancer (CBC) than 
      those with ER/PR (+). There was no significant difference in overall survival 
      (OS) and disease-free survival (DFS) between patients with SBBC and patients with 
      UBC. Patients with MBBC had worse DFS than those with UBC, but OS was similar for 
      both types of patients. Patients with MBBC <55 years at first diagnosis had 
      significantly shorter DFS compared to those with SBBC and UBC. A multivariate Cox 
      proportional hazards model revealed that age >/=55 years and ER/PR negativity of 
      the first tumor were independent risk factors for OS. Independent risk factors 
      for DFS included MBBC, age <55 years, family history of other malignant tumors, 
      ER/PR (-), lymphovascular invasion, and N stage >/=2 of the first tumor. 
      CONCLUSIONS: The OS and DFS of patients with SBBC and UBC were similar. The MBBC 
      patients, especially those <55 years old at first diagnosis, had shorter DFS than 
      patients with UBC.
CI  - 2022 Annals of Translational Medicine. All rights reserved.
FAU - Hong, Chenyan
AU  - Hong C
AD  - School of Medicine, Naikai University, Tianjin, China.
FAU - Zheng, Yiqiong
AU  - Zheng Y
AD  - Department of General Surgery, the First Medical Center of the People's 
      Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Geng, Rui
AU  - Geng R
AD  - Department of General Surgery, the First Medical Center of the People's 
      Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Hu, Huayu
AU  - Hu H
AD  - School of Medicine, Naikai University, Tianjin, China.
FAU - Zhong, Yuting
AU  - Zhong Y
AD  - Department of General Surgery, the First Medical Center of the People's 
      Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Guan, Qingyu
AU  - Guan Q
AD  - School of Medicine, Naikai University, Tianjin, China.
FAU - Zhang, Yanjun
AU  - Zhang Y
AD  - Department of General Surgery, the First Medical Center of the People's 
      Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Li, Xiru
AU  - Li X
AD  - Department of General Surgery, the First Medical Center of the People's 
      Liberation Army (PLA) General Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC9358492
OTO - NOTNLM
OT  - Synchronous bilateral breast cancer (SBBC)
OT  - metachronous bilateral breast cancer (MBBC)
OT  - prognosis
OT  - risk factors
OT  - unilateral breast cancer (UBC)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://atm.amegroups.com/article/view/10.21037/atm-21-5400/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/13 06:01
PMCR- 2022/07/01
CRDT- 2022/08/12 02:45
PHST- 2021/10/11 00:00 [received]
PHST- 2022/03/17 00:00 [accepted]
PHST- 2022/08/12 02:45 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/13 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - atm-10-13-742 [pii]
AID - 10.21037/atm-21-5400 [doi]
PST - ppublish
SO  - Ann Transl Med. 2022 Jul;10(13):742. doi: 10.21037/atm-21-5400.