PMID- 35958024
OWN - NLM
STAT- MEDLINE
DCOM- 20220815
LR  - 20220823
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2022
DP  - 2022
TI  - HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via 
      Inhibiting NLRP3 Inflammation Activation.
PG  - 9251835
LID - 10.1155/2022/9251835 [doi]
LID - 9251835
AB  - Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of cognitive 
      impairment. And the underlying mechanism remains unillustrated. HSPB8 is a member 
      of the small heat shock protein family. In this study, we found that the 
      expression of HSPB8 was upregulated in the hippocampus of high - fat diet (HFD) + 
      streptozotocin (STZ) -  induced diabetic mice and N2a cells exposed to high 
      glucose. Overexpression of HSPB8 relieved cognitive decline in DM mice. 
      Mechanically, HSPB8 overexpression in the hippocampus of diabetic mice inhibited 
      NOD-like receptor protein 3 (NLRP3) inflammasome activation via dephosphorylating 
      mitochondrial fission-associated protein dynamin-related protein 1 (DRP1) at the 
      phosphorylated site Ser616 (p-Drp1S616). Furthermore, HSPB8 overexpression 
      increased mitochondrial membrane potential (MMP) and reduced oxidative stress. 
      These results indicate a protective effect of HSPB8 in the hippocampus of 
      diabetic mice and N2a cells exposed to high glucose. Overexpression of HSPB8 
      might be a useful strategy for treating T2DM-related cognitive decline.
CI  - Copyright (c) 2022 Yanmin Chang et al.
FAU - Chang, Yanmin
AU  - Chang Y
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wu, Yanqing
AU  - Wu Y
AUID- ORCID: 0000-0003-3413-4130
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Jiang, Xingjun
AU  - Jiang X
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhu, Jiahui
AU  - Zhu J
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Cailin
AU  - Wang C
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Ma, Rong
AU  - Ma R
AUID- ORCID: 0000-0001-8811-9003
AD  - Department of Pharmacology, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Li, Gang
AU  - Li G
AUID- ORCID: 0000-0003-3758-5965
AD  - Department of Neurology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20220801
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Hspb8 protein, mouse)
RN  - 0 (Inflammasomes)
RN  - 0 (Molecular Chaperones)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLR Proteins)
RN  - 0 (Nlrp3 protein, mouse)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - *Cognitive Dysfunction
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Glucose/metabolism
MH  - Heat-Shock Proteins
MH  - Inflammasomes/metabolism
MH  - Inflammation
MH  - Mice
MH  - Molecular Chaperones
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - NLR Proteins
PMC - PMC9359860
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflicts of interest.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/16 06:00
PMCR- 2022/08/01
CRDT- 2022/08/12 02:50
PHST- 2022/03/09 00:00 [received]
PHST- 2022/06/20 00:00 [revised]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/08/12 02:50 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/16 06:00 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 10.1155/2022/9251835 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2022 Aug 1;2022:9251835. doi: 10.1155/2022/9251835. 
      eCollection 2022.