PMID- 35959479
OWN - NLM
STAT- MEDLINE
DCOM- 20230116
LR  - 20230116
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 10
DP  - 2022
TI  - Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal 
      carcinoma.
PG  - e13748
LID - 10.7717/peerj.13748 [doi]
LID - e13748
AB  - OBJECTIVE: This study aimed to identify the effects of beamlet width on dynamic 
      intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) 
      and determine the optimal parameters for the most effective radiotherapy plan. 
      METHODS: This study evaluated 20 patients with NPC were selected for dynamic 
      IMRT. Only the beamlet width in the optimization parameters was changed (set to 
      2, 4, 6, 8, and 10 mm that were named BL02, BL04, BL06, BL08, and BL10, 
      respectively) to optimize the results of the five groups of plans. Using the plan 
      quality scoring system, the dose results of the planning target volumes (PTVs) 
      and organs at risks (OARs) were analyzed objectively and comprehensively. The 
      lower the quality score, the better the quality of the plan. The efficiency and 
      accuracy of plan execution were evaluated using monitor units (MUs) and plan 
      delivery time (PDT). RESULTS: The BL04 mm group had the lowest quality score for 
      the targets and OARs (0.087), while the BL10 mm group had the highest total score 
      (1.249). The BL04 mm group had the highest MUs (837 MUs) and longest PDT (358 s). 
      However, the MUs range of each group plan was below 100 MUs, and the PDT range 
      was within 30 s. In the BL02, BL04, BL06, BL08, and BL10 plans, <5 MUs segments 
      accounted for 33%, 16%, 24%, 33%, and 40% of total segments, respectively, with 
      which the lowest was in the BL04 mm group. CONCLUSION: Smaller beamlet widths 
      have not only reduced OARs dose while maintaining high dose coverage to the PTVs, 
      but also lead to more MUs that would produce greater PDT. Considering the quality 
      and efficiency of dynamic IMRT, the beamlet width value of the Monaco treatment 
      planning system set to 4 mm would be optimal for NPC.
CI  - (c)2022 Wu et al.
FAU - Wu, Manya
AU  - Wu M
AD  - Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, Guangdong, China.
FAU - Jin, Jinhui
AU  - Jin J
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Li, Zhenghuan
AU  - Li Z
AD  - Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, Guangdong, China.
FAU - Kong, Fantu
AU  - Kong F
AD  - Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, Guangdong, China.
FAU - He, Yadi
AU  - He Y
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Liu, Lijiang
AU  - Liu L
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Yang, Wei
AU  - Yang W
AD  - School of Biomedical Engineering, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Xu, Xiangying
AU  - Xu X
AD  - Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220805
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
MH  - Humans
MH  - Nasopharyngeal Carcinoma/radiotherapy
MH  - *Radiotherapy, Intensity-Modulated/methods
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy Dosage
MH  - *Nasopharyngeal Neoplasms/radiotherapy
PMC - PMC9359131
OTO - NOTNLM
OT  - Beamlet width
OT  - Delivery efficiency
OT  - IMRT
OT  - NPC
OT  - Plan quality
COIS- The authors declare there are no competing interests.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/13 06:01
PMCR- 2022/08/05
CRDT- 2022/08/12 03:14
PHST- 2022/05/11 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/08/12 03:14 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/13 06:01 [medline]
PHST- 2022/08/05 00:00 [pmc-release]
AID - 13748 [pii]
AID - 10.7717/peerj.13748 [doi]
PST - epublish
SO  - PeerJ. 2022 Aug 5;10:e13748. doi: 10.7717/peerj.13748. eCollection 2022.