PMID- 35961132 OWN - NLM STAT- MEDLINE DCOM- 20220908 LR - 20230112 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 97 DP - 2022 Sep TI - Harmonic ratio is the most responsive trunk-acceleration derived gait index to rehabilitation in people with Parkinson's disease at moderate disease stages. PG - 152-158 LID - S0966-6362(22)00439-8 [pii] LID - 10.1016/j.gaitpost.2022.07.235 [doi] AB - BACKGROUND: Harmonic ratios (HRs), recurrence quantification analysis in the antero-posterior direction (RQA(detAP)), and stride length coefficient of variation (CV) have recently been shown to characterize gait abnormalities and fall risk in people with Parkinson's disease (pwPD) at moderate disease stages. RESEARCH QUESTION: This study aimed to i) assess the internal and external responsiveness to rehabilitation of HR, RQA(detAP), and CV, ii) identify the baseline predictors of normalization of the gait stability indexes, and iii) investigate the correlations between the gait indexes modifications (∆) and clinical and kinematic ∆s in pwPD at Hoehn and Yahr disease staging classification 3. METHODS: The trunk acceleration patterns of 21 pwPD and 21 age- and speed-matched healthy subjects (HSmatched) were acquired during gait using an inertial measurement unit at baseline (T0). pwPD were also assessed after a 4-week rehabilitation period (T1). Each participant's HR in the antero-posterior (HR(AP)), medio-lateral (HR(ML)), and vertical directions, RQA(detAP), CV, spatio-temporal, and kinematic variables were calculated. RESULTS: At T1, HR(AP) and HR(ML) improved to normative values and showed high internal and external responsiveness. Lower HRs and higher pelvic rotation values at baseline were predictors of ∆HRs. A minimal clinically important difference (MCID) >/= 21.5 % is required to normalize HR(AP) with 95 % probability. MCID >/= 36.9 % is required to normalize HR(ML) with 92 % probability. ∆HR(AP) correlated with ∆HR(ML) and both correlated with ∆stride length and ∆pelvic rotation, regardless of ∆gait speed. RQAdetAP and step length CV were not responsive to rehabilitation. SIGNIFICANCE: When using inertial measurement units, HR(AP) and HR(ML) can be considered as responsive outcome measures for assessing the effectiveness of rehabilitation on trunk smoothness during walking in pwPD at moderate disease stages. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Castiglia, Stefano Filippo AU - Castiglia SF AD - Department of Medical and Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Polo Pontino, Corso della Repubblica 70, 04100 Latina, Italy; Department of Brain and Behavioral Sciences, University of Pavia, via Bassi, 21, 27100 Pavia, Italy. Electronic address: stefanofilippo.castiglia@uniroma1.it. FAU - Trabassi, Dante AU - Trabassi D AD - Department of Medical and Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Polo Pontino, Corso della Repubblica 70, 04100 Latina, Italy. FAU - De Icco, Roberto AU - De Icco R AD - Department of Brain and Behavioral Sciences, University of Pavia, via Bassi, 21, 27100 Pavia, Italy; Movement Analysis Research Unit, IRCCS Mondino Foundation, via Mondino, 2, 27100 Pavia, Italy. FAU - Tatarelli, Antonella AU - Tatarelli A AD - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL, via Fontana Candida, 1, Monte Porzio Catone, 00078 Rome, Italy; Department of Human Neurosciences, "Sapienza" University of Rome, viale dell'Universita, 30, 00185 Rome, Italy. FAU - Avenali, Micol AU - Avenali M AD - Department of Brain and Behavioral Sciences, University of Pavia, via Bassi, 21, 27100 Pavia, Italy; Movement Analysis Research Unit, IRCCS Mondino Foundation, via Mondino, 2, 27100 Pavia, Italy. FAU - Corrado, Michele AU - Corrado M AD - Department of Brain and Behavioral Sciences, University of Pavia, via Bassi, 21, 27100 Pavia, Italy; Movement Analysis Research Unit, IRCCS Mondino Foundation, via Mondino, 2, 27100 Pavia, Italy. FAU - Grillo, Valentina AU - Grillo V AD - Movement Analysis Research Unit, IRCCS Mondino Foundation, via Mondino, 2, 27100 Pavia, Italy. FAU - Coppola, Gianluca AU - Coppola G AD - Department of Medical and Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Polo Pontino, Corso della Repubblica 70, 04100 Latina, Italy. FAU - Denaro, Alessandro AU - Denaro A AD - Department of Medical and Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Polo Pontino, Corso della Repubblica 70, 04100 Latina, Italy. FAU - Tassorelli, Cristina AU - Tassorelli C AD - Department of Brain and Behavioral Sciences, University of Pavia, via Bassi, 21, 27100 Pavia, Italy; Movement Analysis Research Unit, IRCCS Mondino Foundation, via Mondino, 2, 27100 Pavia, Italy. FAU - Serrao, Mariano AU - Serrao M AD - Department of Medical and Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Polo Pontino, Corso della Repubblica 70, 04100 Latina, Italy; Movement Analysis Laboratory, Policlinico Italia, piazza del campidano, 6, 00162 Rome, Italy. LA - eng PT - Journal Article DEP - 20220721 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Acceleration MH - Gait MH - Humans MH - *Parkinson Disease/rehabilitation MH - Walking MH - Walking Speed OTO - NOTNLM OT - Accelerometry OT - Gait OT - Movement analysis OT - Movement disorder OT - Parkinsonism COIS- Conflict of interest statement The authors declare no conflicts of interest. EDAT- 2022/08/13 06:00 MHDA- 2022/09/09 06:00 CRDT- 2022/08/12 18:18 PHST- 2022/01/20 00:00 [received] PHST- 2022/07/14 00:00 [revised] PHST- 2022/07/18 00:00 [accepted] PHST- 2022/08/13 06:00 [pubmed] PHST- 2022/09/09 06:00 [medline] PHST- 2022/08/12 18:18 [entrez] AID - S0966-6362(22)00439-8 [pii] AID - 10.1016/j.gaitpost.2022.07.235 [doi] PST - ppublish SO - Gait Posture. 2022 Sep;97:152-158. doi: 10.1016/j.gaitpost.2022.07.235. Epub 2022 Jul 21.