PMID- 35961253
OWN - NLM
STAT- MEDLINE
DCOM- 20221104
LR  - 20221104
IS  - 1525-3171 (Electronic)
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 101
IP  - 10
DP  - 2022 Oct
TI  - Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle 
      fiber types in chickens with hepatic fibrosis.
PG  - 102045
LID - S0032-5791(22)00336-4 [pii]
LID - 10.1016/j.psj.2022.102045 [doi]
LID - 102045
AB  - We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 
      type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic 
      fibrosis induced by bile duct ligation (BDL). Eleven hens, approximately 104 
      weeks old, were randomly assigned to BDL (n = 4) and sham surgery (SHAM; n = 7) 
      groups. In BDL hens, histopathology revealed marked bile duct proliferation and 
      liver fibrosis. The cross-sectional area (CSA) of myofibers from both the 
      pectoralis (PCT) muscles significantly decreased in the BDL group compared with 
      the SHAM group (P < 0.01). In contrast, the CSA of myofibers from the 
      femorotibialis lateralis (FTL) muscle did not decrease in the BDL group. Type I 
      fibers were large, round, and hypertrophic. Elongated type IIA and IIB fibers 
      were also present. For IGF-1 immunostaining, the immunoreaction intensity was 
      higher in the PCT in the BDL group than the SHAM group. Within the BDL group, 
      type I fibers from FTL had a stronger immunoreaction intensity than the type II 
      fibers. For IGF-1R immunostaining, the intensity of the immunoreactions was 
      similar within the PCT in the BDL group compared with the SHAM group. For FTL, 
      type I fibers had stronger reactions to IGF-1R than type II fibers in the BDL 
      group. These results suggest that type I fibers express both IGF-1 and IGF-1R and 
      become hypertrophic in chickens with hepatic fibrosis.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Nagasao, J
AU  - Nagasao J
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan. Electronic address: 
      nagasao@vmas.kitasato-u.ac.jp.
FAU - Fukasawa, H
AU  - Fukasawa H
AD  - Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Yoshioka, K
AU  - Yoshioka K
AD  - Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Fujimura, N
AU  - Fujimura N
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Kobayashi, M
AU  - Kobayashi M
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Tsunemi, Y
AU  - Tsunemi Y
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Nomoto, A
AU  - Nomoto A
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Mitsui, S
AU  - Mitsui S
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Murata, H
AU  - Murata H
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Yokoyama, I
AU  - Yokoyama I
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Komiya, Y
AU  - Komiya Y
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
FAU - Arihara, K
AU  - Arihara K
AD  - Laboratory of Food Function and Safety, School of Veterinary Medicine, Kitasato 
      University, Aomori 034-8628, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220710
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Animals
MH  - Female
MH  - *Chickens
MH  - *Insulin-Like Growth Factor I/genetics/metabolism
MH  - Liver/metabolism
MH  - Liver Cirrhosis/veterinary
MH  - Muscle Fibers, Skeletal/metabolism
MH  - Receptor, IGF Type 1/genetics/metabolism
PMC - PMC9382560
OTO - NOTNLM
OT  - IGF-1
OT  - IGF-1 receptor
OT  - fiber types
OT  - hepatic fibrosis
OT  - hypertrophy
EDAT- 2022/08/13 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/07/10
CRDT- 2022/08/12 18:26
PHST- 2022/02/22 00:00 [received]
PHST- 2022/06/26 00:00 [revised]
PHST- 2022/06/28 00:00 [accepted]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/08/12 18:26 [entrez]
PHST- 2022/07/10 00:00 [pmc-release]
AID - S0032-5791(22)00336-4 [pii]
AID - 102045 [pii]
AID - 10.1016/j.psj.2022.102045 [doi]
PST - ppublish
SO  - Poult Sci. 2022 Oct;101(10):102045. doi: 10.1016/j.psj.2022.102045. Epub 2022 Jul 
      10.