PMID- 35961978
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20230119
IS  - 2041-4889 (Electronic)
VI  - 13
IP  - 8
DP  - 2022 Aug 12
TI  - Chromatin-Associated Molecular Patterns (CAMPs) in sepsis.
PG  - 700
LID - 10.1038/s41419-022-05155-3 [doi]
LID - 700
AB  - Several molecular patterns have been identified that recognize pattern 
      recognition receptors. Pathogen-associated molecular patterns (PAMPs) and 
      damage-associated molecular patterns (DAMPs) are commonly used terminologies to 
      classify molecules originating from pathogen and endogenous molecules, 
      respectively, to heighten the immune response in sepsis. Herein, we focus on a 
      subgroup of endogenous molecules that may be detected as foreign and similarly 
      trigger immune signaling pathways. These chromatin-associated molecules, i.e., 
      chromatin containing nuclear DNA and histones, extracellular RNA, mitochondrial 
      DNA, telomeric repeat-containing RNA, DNA- or RNA-binding proteins, and 
      extracellular traps, may be newly classified as chromatin-associated molecular 
      patterns (CAMPs). Herein, we review the release of CAMPs from cells, their 
      mechanism of action and downstream immune signaling pathways, and targeted 
      therapeutic approaches to mitigate inflammation and tissue injury in inflammation 
      and sepsis.
CI  - (c) 2022. The Author(s).
FAU - Nofi, Colleen P
AU  - Nofi CP
AD  - Center for Immunology and Inflammation, The Feinstein Institutes for Medical 
      Research, Manhasset, NY, USA.
AD  - Elmezi Graduate School of Molecular Medicine, Manhasset, NY, USA.
AD  - Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, 
      NY, USA.
FAU - Wang, Ping
AU  - Wang P
AUID- ORCID: 0000-0002-1557-0394
AD  - Center for Immunology and Inflammation, The Feinstein Institutes for Medical 
      Research, Manhasset, NY, USA. Pwang@northwell.edu.
AD  - Elmezi Graduate School of Molecular Medicine, Manhasset, NY, USA. 
      Pwang@northwell.edu.
AD  - Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, 
      NY, USA. Pwang@northwell.edu.
AD  - Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, 
      Manhasset, NY, USA. Pwang@northwell.edu.
FAU - Aziz, Monowar
AU  - Aziz M
AD  - Center for Immunology and Inflammation, The Feinstein Institutes for Medical 
      Research, Manhasset, NY, USA. Maziz1@northwell.edu.
AD  - Elmezi Graduate School of Molecular Medicine, Manhasset, NY, USA. 
      Maziz1@northwell.edu.
AD  - Department of Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, 
      NY, USA. Maziz1@northwell.edu.
AD  - Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, 
      Manhasset, NY, USA. Maziz1@northwell.edu.
LA  - eng
GR  - R35GM118337/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - R01HL076179/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - U01AI133655/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - U01AI170018/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - R01GM129633/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - U01AI170018/U.S. Department of Health & Human Services | National Institutes 
      of Health (NIH)/
GR  - R01AA028947/U.S. Department of Health & Human Services | NIH | Office of 
      Extramural Research, National Institutes of Health (OER)/
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20220812
PL  - England
TA  - Cell Death Dis
JT  - Cell death & disease
JID - 101524092
RN  - 0 (Chromatin)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Pathogen-Associated Molecular Pattern Molecules)
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - *Chromatin/genetics
MH  - DNA, Mitochondrial
MH  - Humans
MH  - Inflammation
MH  - Pathogen-Associated Molecular Pattern Molecules
MH  - Receptors, Pattern Recognition/metabolism
MH  - *Sepsis/metabolism
PMC - PMC9372964
COIS- The authors declare no competing interests.
EDAT- 2022/08/13 06:00
MHDA- 2022/08/17 06:00
PMCR- 2022/08/12
CRDT- 2022/08/12 23:15
PHST- 2022/03/16 00:00 [received]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/07/28 00:00 [revised]
PHST- 2022/08/12 23:15 [entrez]
PHST- 2022/08/13 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/08/12 00:00 [pmc-release]
AID - 10.1038/s41419-022-05155-3 [pii]
AID - 5155 [pii]
AID - 10.1038/s41419-022-05155-3 [doi]
PST - epublish
SO  - Cell Death Dis. 2022 Aug 12;13(8):700. doi: 10.1038/s41419-022-05155-3.