PMID- 35962259 OWN - NLM STAT- MEDLINE DCOM- 20220930 LR - 20220930 IS - 1432-5233 (Electronic) IS - 0940-5429 (Print) IS - 0940-5429 (Linking) VI - 59 IP - 11 DP - 2022 Nov TI - Increased serum 12-hydroxyeicosatetraenoic acid levels are correlated with an increased risk of diabetic retinopathy in both children and adults with diabetes. PG - 1505-1513 LID - 10.1007/s00592-022-01951-7 [doi] AB - PURPOSE: To investigate the relationship between serum 12-Hydroxyeicosatetraenoic acid (12-HETE) and diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) and adults with type 2 diabetes mellitus (T2DM). METHODS: Children from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study and adults from the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) were examined in 2021. Serum 12-HETE levels were detected and compared. Multivariate logistic regression was used to analyze the relationship between 12-HETE and the rate of DR in diabetic patients. RESULTS: The child study included 4 patients with new-onset DR and 24 patients with T1DM without DR. In children with T1DM, the 12-HETE level was significantly higher in those with DR (P = 0.003). The adult study had two sets, for testing and verification. The test set included 28 patients with new-onset DR and 24 T2DM patients with a course of >/= 20 years who had never developed DR. The verification set included 41 patients with DR, 50 patients without DR and 50 healthy controls. In the adult test set, the 12-HETE level was significantly higher in patients with DR than in those with T2DM without DR (P = 0.003). In the verification set, the 12-HETE level of patients with DR was significantly higher than that of patients without DR (P < 0.0001) and the healthy controls (P < 0.0001). Multivariate logistic regression indicated that 12-HETE was independently associated with DR in both children (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00-1.13, P = 0.041) and adults (test set [OR 9.26, 95% CI 1.77-48.59, P = 0.008], verification set [OR 10.49, 95% CI 3.23-34.05, P < 0.001]). CONCLUSION: Higher serum 12-HETE levels are positively correlated with an increased risk of DR in children with T1DM and adults with T2DM. CI - (c) 2022. The Author(s). FAU - Chen, Shuli AU - Chen S AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Qian, Yu AU - Qian Y AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Lin, Qiurong AU - Lin Q AD - Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. AD - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. FAU - Chen, Zhangling AU - Chen Z AD - Department of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. AD - Department of Ophthalmology, Shanghai Songjiang District Central Hospital, Shanghai, China. FAU - Xiang, Zhaoyu AU - Xiang Z AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Cui, Lipu AU - Cui L AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Sun, Jiaqi AU - Sun J AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Qin, Xinran AU - Qin X AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. FAU - Xu, Yi AU - Xu Y AD - Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. FAU - Lu, Lina AU - Lu L AD - Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. FAU - Zou, Haidong AU - Zou H AUID- ORCID: 0000-0002-6831-7560 AD - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, No.100 Haining Road, Shanghai, 200080, China. zouhaidong@sjtu.edu.cn. AD - Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. AD - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. AD - National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. LA - eng GR - 2021YFC2702100/Chinese National Key Research and Development Program/ GR - 82071012/National Natural Science Foundation of China/ GR - 20DZ1100200/The Science and Technology Commission of Shanghai Municipality/ GR - GWV10.1-XK7/Shanghai Municipal Commission of health (public health system three-year plan-Key Subjects)/ GR - SHDC2020CR30538/The Project of Shanghai Shen Kang Hospital Development Centre/ GR - SHDC2018110/The Project of Shanghai Shen Kang Hospital Development Centre/ GR - 19DZ2250100/Shanghai engineering research center of precise diagnosis and treatment of eye diseases, Shanghai, China/ GR - CTCCR-2018Z01/Shanghai General Hospital, Clinical Research/ PT - Journal Article DEP - 20220812 PL - Germany TA - Acta Diabetol JT - Acta diabetologica JID - 9200299 RN - 59985-28-3 (12-Hydroxy-5,8,10,14-eicosatetraenoic Acid) SB - IM MH - 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid MH - Adolescent MH - Adult MH - Child MH - China/epidemiology MH - Cohort Studies MH - *Diabetes Mellitus, Type 1/complications MH - *Diabetes Mellitus, Type 2/complications MH - *Diabetic Retinopathy/epidemiology/etiology MH - Humans MH - Risk Factors PMC - PMC9374295 OTO - NOTNLM OT - 12-HETE OT - Adult OT - Children OT - Diabetes mellitus OT - Diabetic retinopathy COIS- The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2022/08/13 06:00 MHDA- 2022/10/01 06:00 PMCR- 2022/08/12 CRDT- 2022/08/12 23:33 PHST- 2022/05/25 00:00 [received] PHST- 2022/07/22 00:00 [accepted] PHST- 2022/08/13 06:00 [pubmed] PHST- 2022/10/01 06:00 [medline] PHST- 2022/08/12 23:33 [entrez] PHST- 2022/08/12 00:00 [pmc-release] AID - 10.1007/s00592-022-01951-7 [pii] AID - 1951 [pii] AID - 10.1007/s00592-022-01951-7 [doi] PST - ppublish SO - Acta Diabetol. 2022 Nov;59(11):1505-1513. doi: 10.1007/s00592-022-01951-7. Epub 2022 Aug 12.