PMID- 35963450
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221207
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 167
DP  - 2022 Oct 1
TI  - Intrinsic capacity and 10-year mortality: Findings from a cohort of older people.
PG  - 111926
LID - S0531-5565(22)00234-0 [pii]
LID - 10.1016/j.exger.2022.111926 [doi]
AB  - BACKGROUND AND OBJECTIVES: Longitudinal data with regard to the association 
      between intrinsic capacity (IC) and mortality is required for prevention efforts. 
      We examined the association between IC and 10-year mortality among older people. 
      RESEARCH DESIGN AND METHODS: We recruited a cohort of 2032 Chinese people aged 
      70 years and older, 1371 of them could be traced over follow-up, of which 1096 
      died within 10 years. Of those who were traceable, 846 were complete cases 
      regarding the data for the exposure, outcome and covariates. Multiple imputation 
      was used to handle missing data. Nine indicators were included to represent the 
      construct of IC. All-cause mortality was collected from the Death Registry. 
      Multivariable Cox proportional hazard regression model and Kaplan-Meier estimator 
      were used to assess the association between IC and mortality. RESULTS: The mean 
      age of the 2032 participants was 79.7 years and 51 % were female. Compared with 
      those in the lowest (best) quartile of IC, those in the highest (worst) quartile 
      were associated with 1.48-fold (95 % CI 1.21-1.82) higher risk of mortality, 
      after adjustment for sociodemographic variables. When past medical illnesses were 
      further adjusted, the hazard ratio was attenuated (1.41; 95 % CI 1.15-1.73). 
      Kaplan-Meier estimator for survival probability similarly showed a graded 
      mortality pattern. The association between IC and mortality remained similar when 
      the analysis was confined to community-dwelling older people. DISCUSSION AND 
      IMPLICATIONS: IC is associated with mortality in a dose-response fashion. 
      Assessment of IC should be instituted in community and institutional settings to 
      enable formulation of early interventions.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Yu, Ruby
AU  - Yu R
AD  - Department of Medicine & Therapeutics, Faculty of Medicine, the Chinese 
      University of Hong Kong, New Territories, Hong Kong, China; Jockey Club Institute 
      of Ageing, the Chinese University of Hong Kong, New Territories, Hong Kong, 
      China. Electronic address: rubyyu@cuhk.edu.hk.
FAU - Lai, Eric T C
AU  - Lai ETC
AD  - Institute of Health Equity, the Chinese University of Hong Kong, New Territories, 
      Hong Kong, China.
FAU - Leung, Grace
AU  - Leung G
AD  - Jockey Club Institute of Ageing, the Chinese University of Hong Kong, New 
      Territories, Hong Kong, China.
FAU - Ho, Suzanne C
AU  - Ho SC
AD  - Division of Epidemiology, the Jockey Club School of Public Health and Primary 
      Care, the Chinese University of Hong Kong, New Territories, Hong Kong, China.
FAU - Woo, Jean
AU  - Woo J
AD  - Department of Medicine & Therapeutics, Faculty of Medicine, the Chinese 
      University of Hong Kong, New Territories, Hong Kong, China; Jockey Club Institute 
      of Ageing, the Chinese University of Hong Kong, New Territories, Hong Kong, 
      China; Institute of Health Equity, the Chinese University of Hong Kong, New 
      Territories, Hong Kong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220811
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asian People
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - *Independent Living
MH  - Male
MH  - Proportional Hazards Models
MH  - Survival Analysis
OTO - NOTNLM
OT  - Biological age
OT  - Healthy ageing
OT  - Intrinsic capacity
OT  - Mortality
OT  - Survival
EDAT- 2022/08/14 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/13 19:34
PHST- 2022/05/23 00:00 [received]
PHST- 2022/07/27 00:00 [revised]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/08/14 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/13 19:34 [entrez]
AID - S0531-5565(22)00234-0 [pii]
AID - 10.1016/j.exger.2022.111926 [doi]
PST - ppublish
SO  - Exp Gerontol. 2022 Oct 1;167:111926. doi: 10.1016/j.exger.2022.111926. Epub 2022 
      Aug 11.