PMID- 35964414
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221128
IS  - 1557-9816 (Electronic)
IS  - 0955-470X (Linking)
VI  - 36
IP  - 4
DP  - 2022 Dec
TI  - Natural killer cells and killer cell immunoglobulin-like receptors in solid organ 
      transplantation: Protectors or opponents?
PG  - 100723
LID - S0955-470X(22)00046-5 [pii]
LID - 10.1016/j.trre.2022.100723 [doi]
AB  - Among all the cells of innate immunity, natural killer (NK) cells are well-known 
      for the fight against tumors and virally-infected cells. NK cells have been 
      implicated in the pathogenesis of immune-mediated allograft damage, but mounting 
      evidence suggests they can potentially promote allograft tolerance as well. In 
      addition, NK cells express a wide variety of activating and inhibiting receptors, 
      and the signals sent by these molecules, particularly killer cell 
      immunoglobulin-like receptors (KIRs), determine their ultimate function. The role 
      of KIRs and their human leukocyte antigen (HLA) class I ligands have been 
      extensively investigated in hematopoietic stem cell transplantation (HSCT). 
      Previous studies have suggested that, in the setting of solid organ 
      transplantation, having certain KIR genes or KIR/HLA combinations probably 
      affects allograft survival. Therefore, it may be helpful to analyze KIR/HLA 
      combinations in donors and recipients to choose the optimal donor, anticipate 
      harmful effects post-transplantation, and develop NK cell-based immunotherapies 
      to enhance the success of solid organ transplantation. In this review, we will 
      discuss the dual function of NK cells in solid organ transplantation, followed by 
      a brief introduction to KIRs and the association of KIR and HLA genes with 
      kidney, liver, and lung transplant outcomes.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Zamir, Mina Roshan
AU  - Zamir MR
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran. Electronic address: mroshanzamir@razi.tums.ac.ir.
FAU - Shahi, Abbas
AU  - Shahi A
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran; Noncommunicable Diseases Research Center, Fasa University 
      of Medical Sciences, Fasa, Iran.
FAU - Salehi, Saeedeh
AU  - Salehi S
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Amirzargar, Aliakbar
AU  - Amirzargar A
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran. Electronic address: minarzs95@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220729
PL  - United States
TA  - Transplant Rev (Orlando)
JT  - Transplantation reviews (Orlando, Fla.)
JID - 8804364
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Humans
MH  - *Receptors, KIR
MH  - *Organ Transplantation
MH  - Killer Cells, Natural
MH  - Transplantation, Homologous
MH  - Tissue Donors
OTO - NOTNLM
OT  - Human leukocyte antigen (HLA)
OT  - Killer cell immunoglobulin-like receptor (KIR)
OT  - Natural killer cell (NK cell)
OT  - Transplantation
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2022/08/15 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/08/14 18:10
PHST- 2022/04/14 00:00 [received]
PHST- 2022/07/20 00:00 [revised]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/15 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/08/14 18:10 [entrez]
AID - S0955-470X(22)00046-5 [pii]
AID - 10.1016/j.trre.2022.100723 [doi]
PST - ppublish
SO  - Transplant Rev (Orlando). 2022 Dec;36(4):100723. doi: 10.1016/j.trre.2022.100723. 
      Epub 2022 Jul 29.