PMID- 35965812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220816
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 10
IP  - 14
DP  - 2022 Jul
TI  - 3.0T cardiac magnetic resonance quantification of native T1 and myocardial 
      extracellular volume for the diagnosis of late gadolinium enhancement-negative 
      cardiac amyloidosis.
PG  - 794
LID - 10.21037/atm-22-3251 [doi]
LID - 794
AB  - BACKGROUND: Late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) 
      is useful for the detection of cardiac amyloidosis (CA), but characteristic LGE 
      patterns do not always occur or they appear late in the disease. Native T1 and 
      extracellular volume (ECV) by T1 mapping may improve disease detection and 
      quantify myocardial amyloid load. METHODS: Thirty patients with definite CA, 10 
      patients with possible CA, 20 patients with hypertrophic cardiomyopathy (HCM) and 
      40 healthy volunteers were performed 3.0-T CMR including cine, pre- and 
      postcontrast T1 mapping and LGE. Receiver-operating characteristic (ROC) curves 
      were constructed to assess the diagnostic ability of native T1 and ECV for CA. 
      Correlation analysis between native T1 or ECV and cardiac biomarkers, structure, 
      and function indexes were assessed using Pearson or Spearman correlation, as 
      appropriate. RESULTS: Native T1 values were 1,429+/-93, 1,290+/-49, 1,304+/-42, and 
      1,225+/-21 ms, in definite CA, possible CA, HCM, and healthy controls, 
      respectively. ECV values were 44%+/-9%, 34%+/-5%, 33%+/-4%, and 24%+/-3%, in definite CA, 
      possible CA, HCM, and healthy controls, respectively. Native T1 [area under curve 
      (AUC) =0.89, 95% confidence interval (CI): 0.75-1.00, P<0.001] and ECV (AUC 
      =0.99, 95% CI: 0.98-1.00, P<0.001) showed good ability to differentiate 
      LGE-negative patients with possible CA from healthy controls, especially ECV. 
      Positive correlations were found between native T1 or ECV and New York Heart 
      Association (NYHA) functional class (r=0.673 and r=0.594, respectively; P<0.001), 
      NT-proBNP (r=0.668 and r=0.603, respectively; P<0.001), troponin T (r=0.724 and 
      r=0.591, respectively; P<0.001), left ventricular (LV) mass index (r=0.668 and 
      r=0.579, respectively; P<0.001), and global LV wall thickness (r=0.765 and 
      r=0.629, respectively; P<0.001). Negative correlations were found between native 
      T1 or ECV and left ventricular ejection fraction (LVEF) (r=-0.761 and r=-0.668, 
      respectively; P<0.001) and left ventricular stroke volume (LVSV) (r=-0.777 and 
      r=-0.729, respectively; P<0.001). CONCLUSIONS: Native T1 and ECV, which are able 
      to reflect cardiac biochemistry, structure, and function, have high diagnostic 
      accuracy for detecting CA, especially in LGE-negative patients, and thus could be 
      used for early diagnosis of CA.
CI  - 2022 Annals of Translational Medicine. All rights reserved.
FAU - Liu, Yumeng
AU  - Liu Y
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhu, Jingfen
AU  - Zhu J
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Chen, Meng
AU  - Chen M
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Wang, Lingjie
AU  - Wang L
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Zhu, Mo
AU  - Zhu M
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Weng, Zhen
AU  - Weng Z
AD  - MOE Engineering Center of Hematological Disease, Soochow University, Suzhou, 
      China.
AD  - Cyrus Tang Hematology Center, Soochow University, Suzhou, China.
AD  - National Clinical Research Center for Hematologic Diseases, the First Affiliated 
      Hospital of Soochow University, Suzhou, China.
AD  - Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
FAU - Hu, Chunhong
AU  - Hu C
AD  - Department of Radiology, the First Affiliated Hospital of Soochow University, 
      Suzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC9372670
OTO - NOTNLM
OT  - Cardiac amyloidosis (CA)
OT  - cardiac magnetic resonance (CMR)
OT  - extracellular volume (ECV)
OT  - native T1
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://atm.amegroups.com/article/view/10.21037/atm-22-3251/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/16 06:01
PMCR- 2022/07/01
CRDT- 2022/08/15 03:29
PHST- 2022/06/01 00:00 [received]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/08/15 03:29 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/16 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - atm-10-14-794 [pii]
AID - 10.21037/atm-22-3251 [doi]
PST - ppublish
SO  - Ann Transl Med. 2022 Jul;10(14):794. doi: 10.21037/atm-22-3251.