PMID- 35966017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220816
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - TRP channels and monoterpenes: Past and current leads on analgesic properties.
PG  - 945450
LID - 10.3389/fnmol.2022.945450 [doi]
LID - 945450
AB  - The activation of the transient receptor potential (TRP) channels expressed by 
      sensory neurons is essential to the transduction of thermal and mechanical 
      sensory information. In the setting of chronic inflammatory conditions, the 
      activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 
      (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity 
      reactions. Monoterpenes, among which pulegone and menthol, a major class of 
      phytocompounds present in essential oils of medicinal plants, are known 
      modulators of those TRP channels activity. In the present review, we correlate 
      the monoterpene content of plants with their historical therapeutic properties. 
      We then describe how monoterpenes exert their anti-inflammatory and 
      antihyperalgesia effects through modulation of TRP channels activity. Finally, we 
      discuss the importance and the potential of characterizing new plant extracts and 
      reassessing studied plant extracts for the development of ethnopharmacology-based 
      innovative treatments for chronic pain. This review suggests that monoterpene 
      solutions, based on composition from traditional healing herbs, offer an 
      interesting avenue for the development of new phytotherapeutic treatments to 
      alleviate chronic inflammatory pain conditions.
CI  - Copyright (c) 2022 Petitjean, Heberle, Hilfiger, Lapies, Rodrigue and Charlet.
FAU - Petitjean, Hugues
AU  - Petitjean H
AD  - Benephyt, Strasbourg, France.
FAU - Heberle, Elea
AU  - Heberle E
AD  - Benephyt, Strasbourg, France.
FAU - Hilfiger, Louis
AU  - Hilfiger L
AD  - Benephyt, Strasbourg, France.
AD  - Centre National de la Recherche Scientifique, University of Strasbourg, Institute 
      of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, France.
FAU - Lapies, Olga
AU  - Lapies O
AD  - Centre National de la Recherche Scientifique, University of Strasbourg, Institute 
      of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, France.
FAU - Rodrigue, Guillaume
AU  - Rodrigue G
AD  - Benephyt, Strasbourg, France.
FAU - Charlet, Alexandre
AU  - Charlet A
AD  - Centre National de la Recherche Scientifique, University of Strasbourg, Institute 
      of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220729
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC9373873
OTO - NOTNLM
OT  - TRP
OT  - hyperalgesia
OT  - inflammation
OT  - menthol
OT  - monoterpenes
OT  - pain
OT  - pulegone
EDAT- 2022/08/16 06:00
MHDA- 2022/08/16 06:01
PMCR- 2022/01/01
CRDT- 2022/08/15 03:33
PHST- 2022/05/16 00:00 [received]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/08/15 03:33 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/16 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.945450 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Jul 29;15:945450. doi: 10.3389/fnmol.2022.945450. 
      eCollection 2022.