PMID- 35966068
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220825
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Differences in structural connectivity between diabetic and psychological 
      erectile dysfunction revealed by network-based statistic: A diffusion tensor 
      imaging study.
PG  - 892563
LID - 10.3389/fendo.2022.892563 [doi]
LID - 892563
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) has been found to be associated 
      with abnormalities of the central and peripheral vascular nervous system, which 
      were considered to be involved in the development of cognitive impairments and 
      erectile dysfunction (ED). In addition, altered brain function and structure were 
      identified in patients with ED, especially psychological ED (pED). However, the 
      similarities and the differences of the central neural mechanisms underlying pED 
      and T2DM with ED (DM-ED) remained unclear. METHODS: Diffusion tensor imaging data 
      were acquired from 30 T2DM, 32 ED, and 31 DM-ED patients and 47 healthy controls 
      (HCs). Then, whole-brain structural networks were constructed, which were mapped 
      by connectivity matrices (90 x 90) representing the white matter between 90 brain 
      regions parcellated by the anatomical automatic labeling template. Finally, the 
      method of network-based statistic (NBS) was applied to assess the group 
      differences of the structural connectivity. RESULTS: Our NBS analysis 
      demonstrated three subnetworks with reduced structural connectivity in DM, pED, 
      and DM-ED patients when compared to HCs, which were predominantly located in the 
      prefrontal and subcortical areas. Compared with DM patients, DM-ED patients had 
      an impaired subnetwork with increased structural connectivity, which were 
      primarily located in the parietal regions. Compared with pED patients, an altered 
      subnetwork with increased structural connectivity was identified in DM-ED 
      patients, which were mainly located in the prefrontal and cingulate areas. 
      CONCLUSION: These findings highlighted that the reduced structural connections in 
      the prefrontal and subcortical areas were similar mechanisms to those associated 
      with pED and DM-ED. However, different connectivity patterns were found between 
      pED and DM-ED, and the increased connectivity in the frontal-parietal network 
      might be due to the compensation mechanisms that were devoted to improving 
      erectile function.
CI  - Copyright (c) 2022 Chen, Wu, Huang, Sun, Xiang, Xu, Chen, Xu, Yang and Chen.
FAU - Chen, Jianhuai
AU  - Chen J
AD  - Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Wu, Jindan
AU  - Wu J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Huang, Xinfei
AU  - Huang X
AD  - Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Sun, Rui
AU  - Sun R
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Xiang, Ziliang
AU  - Xiang Z
AD  - Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Xu, Yan
AU  - Xu Y
AD  - Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Chen, Shi
AU  - Chen S
AD  - Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Xu, Weilong
AU  - Xu W
AD  - Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Urology, Jiangsu Provincial People's Hospital, First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
AD  - Department of Urology, People's Hospital of Xinjiang Kizilsu Kirgiz Autonomous 
      Prefecture, Artux, Xinjiang, China.
FAU - Chen, Yun
AU  - Chen Y
AD  - Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, 
      Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220727
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Brain
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Diffusion Tensor Imaging/methods
MH  - *Erectile Dysfunction/diagnostic imaging/etiology
MH  - Humans
MH  - Male
MH  - *White Matter
PMC - PMC9365033
OTO - NOTNLM
OT  - diffusion tensor imaging
OT  - erectile dysfunction
OT  - network-based statistic
OT  - psychological erectile dysfunction
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/17 06:00
PMCR- 2022/01/01
CRDT- 2022/08/15 03:34
PHST- 2022/03/09 00:00 [received]
PHST- 2022/07/01 00:00 [accepted]
PHST- 2022/08/15 03:34 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.892563 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jul 27;13:892563. doi: 
      10.3389/fendo.2022.892563. eCollection 2022.