PMID- 35966092 OWN - NLM STAT- MEDLINE DCOM- 20220816 LR - 20220826 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - Modified acupuncture therapy, long-term acupoint stimulation versus sham control for weight control: a multicenter, randomized controlled trial. PG - 952373 LID - 10.3389/fendo.2022.952373 [doi] LID - 952373 AB - OBJECTIVE: Long-term acupoint stimulation (LAS), also called embedding acupuncture, is a modified acupuncture technique. The preliminary results have demonstrated its efficacy in body-weight control. However, the low quality of available trials limited its application. This study aimed to evaluate the efficacy and safety of LAS in body-weight control by using a randomized, parallel, sham-controlled clinical trial design. METHODS: This was a randomized, single-blind, sham-controlled clinical trial including 84 adult participants (18-60 years) with a body mass index (BMI) of >/= 24 kg/m(2) conducted in three general hospitals in Shanghai, China. Participants were equally assigned to receive LAS or sham LAS (SLAS) once per 10 days, eight times in total. After completion, an additional intervention with a 3-month follow-up period was set to examine the continued effect of LAS. The primary outcome was the change in body weight from baseline to treatment endpoint within the intention-to-treat (ITT) analysis. Secondary outcomes contained changes in waist-to-hip ratio (WHR), lipid metabolism, and visceral and subcutaneous adipose tissues. RESULTS: From 14 May 2018 to 03 November 2019, 84 participants out of 201 screened individuals met the eligibility criteria, were randomized, and were analyzed (42 participants in each group). From baseline to treatment endpoint, the body-weight reduction in the LAS group was significantly larger than in the sham control (net difference: 1.57 kg, 95% CI: 0.29-2.86, p = 0.012). The superior weight reduction effect persisted in the follow-up period (net difference: 3.20 kg, 95% CI: 1.17-5.21, p = 0.001). LAS therapy also showed improvement in triglyceride and subcutaneous adipose tissue (SAT) compared with sham control. One participant in the LAS group reported a slightly uncomfortable and tingling sensation after the additional intervention. No other adverse events (AEs) were documented. CONCLUSION: LAS, a modified acupuncture technique, is safe and effective in body-weight control. It could be used as an alternative choice to classical acupuncture for obesity management. CLINICAL TRIAL REGISTRATION: [www.chictr.org.cn], identifier [ChiCTR1800015498]. CI - Copyright (c) 2022 Dai, Wang, Zhang, Wang, Zheng, Li, Zhou, Zhou and Ji. FAU - Dai, Liang AU - Dai L AD - Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Clinical Research Academy, Peking University Shenzhen Hospital, Peking University, Shenzhen, China. FAU - Wang, Miao AU - Wang M AD - Department of Internal Medicine of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Zhang, Ke-Pei AU - Zhang KP AD - Department of Internal Medicine of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Wang, Lin AU - Wang L AD - Department of Internal Medicine of Traditional Chinese Medicine, Shanghai Pudong New Area Peoples' Hospital, Shanghai, China. FAU - Zheng, Hui-Min AU - Zheng HM AD - Department of Acupuncture and Moxibustion, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Li, Chun-Bo AU - Li CB AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhou, Wen-Jun AU - Zhou WJ AD - Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Zhou, Shi-Gao AU - Zhou SG AD - Department of Internal Medicine of Traditional Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Ji, Guang AU - Ji G AD - Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. LA - eng SI - ChiCTR/ChiCTR1800015498 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20220728 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - *Acupuncture Points MH - *Acupuncture Therapy/adverse effects/methods MH - Adult MH - China MH - Humans MH - Single-Blind Method MH - Time Factors MH - Treatment Outcome MH - Weight Loss PMC - PMC9365970 OTO - NOTNLM OT - acupuncture OT - long-term acupoint stimulation OT - randomized controlled trial OT - subcutaneous adipose tissue OT - visceral adipose tissue OT - weight control COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/08/16 06:00 MHDA- 2022/08/17 06:00 PMCR- 2022/01/01 CRDT- 2022/08/15 03:34 PHST- 2022/05/25 00:00 [received] PHST- 2022/07/05 00:00 [accepted] PHST- 2022/08/15 03:34 [entrez] PHST- 2022/08/16 06:00 [pubmed] PHST- 2022/08/17 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.952373 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2022 Jul 28;13:952373. doi: 10.3389/fendo.2022.952373. eCollection 2022.