PMID- 35966561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220816
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Prosthesis-patient mismatch following transcatheter aortic valve replacement for 
      degenerated transcatheter aortic valves: the TRANSIT-PPM international project.
PG  - 931207
LID - 10.3389/fcvm.2022.931207 [doi]
LID - 931207
AB  - BACKGROUND: A severe prosthesis-patient mismatch (PPM) is associated with adverse 
      outcomes following transcatheter aortic valve replacement (TAVR) for de novo 
      aortic stenosis or a failed surgical bioprosthesis. The impact of severe PPM in 
      patients undergoing TAV-in-TAVR is unknown. AIM: We sought to investigate the 
      incidence and 1-year outcomes of different grades of PPM in patients undergoing 
      TAV-in-TAVR. MATERIALS AND METHODS: The TRANSIT-PPM is an international registry, 
      including cases of degenerated TAVR treated with a second TAVR. PPM severity, as 
      well as in-hospital, 30-day, and 1-year outcomes were defined according to the 
      Valve Academic Research Consortium-3 (VARC-3) criteria. RESULTS: Among 28 
      centers, 155 patients were included. Severe PPM was found in 6.5% of patients, 
      whereas moderate PPM was found in 14.2% of patients. The rate of severe PPM was 
      higher in patients who underwent TAV-in-TAVR with a second supra-annular 
      self-expanding (S-SE) TAVR (10%, p = 0.04). Specifically, the rate of severe PPM 
      was significantly higher among cases of a SE TAVR implanted into a 
      balloon-expandable (BE) device (19%, p = 0.003). At 1-year follow-up, the rate of 
      all-cause mortality, and the rate of patients in the New York Heart Association 
      (NYHA) class III/IV were significantly higher in the cohort of patients with 
      severe PPM (p = 0.016 and p = 0.0001, respectively). Almost all the patients with 
      a severe PPM after the first TAVR had a failed < 23 mm BE transcatheter heart 
      valve (THV): the treatment with an S-SE resolved the severe PPM in the majority 
      of the cases. CONCLUSION: After TAV-in-TAVR, in a fifth of the cases, a moderate 
      or severe PPM occurred. A severe PPM is associated with an increased 1-year 
      all-cause mortality. CLINICAL TRIAL REGISTRATION: [https://clinicaltrials.gov], 
      identifier [NCT04500964].
CI  - Copyright (c) 2022 Testa, Casenghi, Criscione, Van Mieghem, Tchetche, Asgar, De 
      Backer, Latib, Reimers, Stefanini, Trani, Giannini, Bartorelli, Wojakowski, 
      Dabrowski, Jagielak, Banning, Kharbanda, Moreno, Schofer, Brinkmann, van Royen, 
      Pinto, Serra, Segev, Giordano, Brambilla, Agnifili, Rubbio, Squillace, Oreglia, 
      Tanja, McCabe, Abizaid, Voskuil, Teles, Zoccai, Sondergaard and Bedogni.
FAU - Testa, Luca
AU  - Testa L
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Casenghi, Matteo
AU  - Casenghi M
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Criscione, Enrico
AU  - Criscione E
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Van Mieghem, Nicolas M
AU  - Van Mieghem NM
AD  - Erasmus University Medical Center, Rotterdam, Netherlands.
FAU - Tchetche, Didier
AU  - Tchetche D
AD  - Groupe CardioVasculaire Interventionnel, Clinique Pasteur, Toulouse, France.
FAU - Asgar, Anita W
AU  - Asgar AW
AD  - Montreal Heart Institute, Montreal, QC, Canada.
FAU - De Backer, Ole
AU  - De Backer O
AD  - Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
FAU - Latib, Azeem
AU  - Latib A
AD  - Montefiore Medical Center, New York, NY, United States.
FAU - Reimers, Bernhard
AU  - Reimers B
AD  - CCS Humanitas Research Hospital, Rozzano-Milan, Italy.
FAU - Stefanini, Giulio
AU  - Stefanini G
AD  - CCS Humanitas Research Hospital, Rozzano-Milan, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, 
      Italy.
FAU - Trani, Carlo
AU  - Trani C
AD  - Policlinico Universitario A. Gemelli, Rome, Italy.
FAU - Giannini, Francesco
AU  - Giannini F
AD  - Maria Cecilia Hospital, Cotignola, Ravenna, Italy.
FAU - Bartorelli, Antonio
AU  - Bartorelli A
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
AD  - Department of Biomedical and Clinical Sciences "Luigi Sacco", University of 
      Milan, Milan, Italy.
FAU - Wojakowski, Wojtek
AU  - Wojakowski W
AD  - Medical University of Silesia, Katowice, Poland.
FAU - Dabrowski, Maciej
AU  - Dabrowski M
AD  - Department of Interventional Cardiology and Angiology, National Institute of 
      Cardiology, Warsaw, Poland.
FAU - Jagielak, Dariusz
AU  - Jagielak D
AD  - Department of Cardiology, Medical University, Gdansk, Poland.
FAU - Banning, Adrian P
AU  - Banning AP
AD  - John Radcliffe Hospital, Oxford, United Kingdom.
FAU - Kharbanda, Rajesh
AU  - Kharbanda R
AD  - John Radcliffe Hospital, Oxford, United Kingdom.
FAU - Moreno, Raul
AU  - Moreno R
AD  - Hospital La Paz, IdiPAZ, CIBER-CV, Madrid, Spain.
FAU - Schofer, Joachim
AU  - Schofer J
AD  - MVZ Department Structural Heart Disease at St. Georg, Hamburg, Germany.
FAU - Brinkmann, Christina
AU  - Brinkmann C
AD  - MVZ Department Structural Heart Disease at St. Georg, Hamburg, Germany.
FAU - van Royen, Niels
AU  - van Royen N
AD  - Radboud University Medical Center, Nijmegen, Netherlands.
FAU - Pinto, Duane
AU  - Pinto D
AD  - Beth Israel Deaconess Medical Center, Boston, MA, United States.
FAU - Serra, Antoni
AU  - Serra A
AD  - Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
FAU - Segev, Amit
AU  - Segev A
AD  - The Heart and Vascular Center, Chaim Sheba Medical Center, Ramat Gan, Israel.
FAU - Giordano, Arturo
AU  - Giordano A
AD  - Pineta Grande Hospital, Caserta, Italy.
FAU - Brambilla, Nedy
AU  - Brambilla N
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Agnifili, Mauro
AU  - Agnifili M
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Rubbio, Antonio Popolo
AU  - Rubbio AP
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Squillace, Mattia
AU  - Squillace M
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
FAU - Oreglia, Jacopo
AU  - Oreglia J
AD  - Niguarda Ca Granda Hospital, Milan, Italy.
FAU - Tanja, Rudolph
AU  - Tanja R
AD  - Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
FAU - McCabe, James M
AU  - McCabe JM
AD  - University of Washington, Seattle, WA, United States.
FAU - Abizaid, Alexander
AU  - Abizaid A
AD  - Instituto do Coracao (Incor), Sao Paulo, Brazil.
FAU - Voskuil, Michiel
AU  - Voskuil M
AD  - University Medical Center, Utrecht, Netherlands.
FAU - Teles, Rui
AU  - Teles R
AD  - Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
FAU - Zoccai, Giuseppe Biondi
AU  - Zoccai GB
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Latina, Italy.
AD  - Mediterranea Cardiocentro, Naples, Italy.
FAU - Sondergaard, Lars
AU  - Sondergaard L
AD  - Montreal Heart Institute, Montreal, QC, Canada.
FAU - Bedogni, Francesco
AU  - Bedogni F
AD  - IRCCS Policlinico S. Donato, Milan, Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT04500964
PT  - Journal Article
DEP - 20220729
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9372302
OTO - NOTNLM
OT  - TAVR
OT  - TAVR in TAVR
OT  - failed TAVR
OT  - mortality
OT  - prosthesis-patient mismatch
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/16 06:01
PMCR- 2022/01/01
CRDT- 2022/08/15 03:43
PHST- 2022/04/28 00:00 [received]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/08/15 03:43 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/16 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.931207 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Jul 29;9:931207. doi: 10.3389/fcvm.2022.931207. 
      eCollection 2022.