PMID- 35967869
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220817
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 12
DP  - 2022
TI  - Pathological and protective roles of dendritic cells in Mycobacterium 
      tuberculosis infection: Interaction between host immune responses and pathogen 
      evasion.
PG  - 891878
LID - 10.3389/fcimb.2022.891878 [doi]
LID - 891878
AB  - Dendritic cells (DCs) are principal defense components that play multifactorial 
      roles in translating innate immune responses to adaptive immunity in 
      Mycobacterium tuberculosis (Mtb) infections. The heterogeneous nature of DC 
      subsets follows their altered functions by interacting with other immune cells, 
      Mtb, and its products, enhancing host defense mechanisms or facilitating pathogen 
      evasion. Thus, a better understanding of the immune responses initiated, 
      promoted, and amplified or inhibited by DCs in Mtb infection is an essential step 
      in developing anti-tuberculosis (TB) control measures, such as host-directed 
      adjunctive therapy and anti-TB vaccines. This review summarizes the recent 
      advances in salient DC subsets, including their phenotypic classification, 
      cytokine profiles, functional alterations according to disease stages and 
      environments, and consequent TB outcomes. A comprehensive overview of the role of 
      DCs from various perspectives enables a deeper understanding of TB pathogenesis 
      and could be useful in developing DC-based vaccines and immunotherapies.
CI  - Copyright (c) 2022 Kim and Shin.
FAU - Kim, Hongmin
AU  - Kim H
AD  - Department of Microbiology, Institute for Immunology and Immunological Diseases, 
      Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University 
      College of Medicine, Seoul, South Korea.
FAU - Shin, Sung Jae
AU  - Shin SJ
AD  - Department of Microbiology, Institute for Immunology and Immunological Diseases, 
      Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University 
      College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220728
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
RN  - 0 (Tuberculosis Vaccines)
SB  - IM
MH  - Dendritic Cells
MH  - Humans
MH  - Immunity, Innate
MH  - *Mycobacterium tuberculosis
MH  - *Tuberculosis Vaccines
MH  - *Tuberculosis, Lymph Node
PMC - PMC9366614
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - dendritic cells
OT  - host-directed strategy
OT  - pathogenesis
OT  - protective immunity
OT  - vaccine
COIS- The authors declare that this review was conducted without any commercial or 
      financial relationships that could be construed as a potential conflict of 
      interest.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/17 06:00
PMCR- 2022/01/01
CRDT- 2022/08/15 04:04
PHST- 2022/03/08 00:00 [received]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/08/15 04:04 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2022.891878 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2022 Jul 28;12:891878. doi: 
      10.3389/fcimb.2022.891878. eCollection 2022.