PMID- 35968536
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220816
IS  - 2329-048X (Electronic)
IS  - 2329-048X (Linking)
VI  - 9
DP  - 2022 Jan-Dec
TI  - Cefepime-Induced Nonconvulsive Status Epilepticus in a Pediatric Patient with 
      Normal Renal Function.
PG  - 2329048X221119575
LID - 10.1177/2329048X221119575 [doi]
LID - 2329048X221119575
AB  - Introduction: Cefepime, a fourth-generation cephalosporin, is known to risk the 
      induction of neurotoxic impairment from confusion to nonconvulsive status 
      epilepticus (NCSE). Neurotoxic effects of cefepime are most commonly evident in 
      the setting of impaired renal function in adults; however, are rarely present in 
      those with normal renal excretion function or in the pediatric population. Case: 
      We present a case of a 16-year-old female with a complicated past medical history 
      but no accounts of impaired renal function yet, after starting cefepime, 
      presented with encephalopathy, intermittent stimulus-induced posturing, and was 
      found to have NCSE. Discontinuation of cefepime and administration of additional 
      antiepileptics provided significant improvement in EEG and allowed the patient to 
      return to baseline within two days. Conclusion: Cefepime-induced nonconvulsive 
      status epilepticus should be considered in any patient with or without impaired 
      renal function that shows acute changes in mental status, and/or reduced 
      consciousness, after initiating cefepime treatment.
CI  - (c) The Author(s) 2022.
FAU - Nguyen, Clever
AU  - Nguyen C
AUID- ORCID: 0000-0001-9422-5849
AD  - Penn State College of Medicine, Hershey, PA, USA. RINGGOLD: 12310
FAU - Clegg, Taylor
AU  - Clegg T
AD  - Penn State College of Medicine, Hershey, PA, USA. RINGGOLD: 12310
FAU - Kumar, Ashutosh
AU  - Kumar A
AD  - Department of Pediatrics and Neurology, Penn State Health Milton S. Hershey 
      Medical Center, Hershey, PA, USA.
FAU - Paudel, Sita
AU  - Paudel S
AD  - Department of Pediatrics and Neurology, Penn State Health Milton S. Hershey 
      Medical Center, Hershey, PA, USA.
LA  - eng
PT  - Case Reports
DEP - 20220807
PL  - United States
TA  - Child Neurol Open
JT  - Child neurology open
JID - 101691975
PMC - PMC9364176
OTO - NOTNLM
OT  - EEG
OT  - cefepime
OT  - neurotoxicity
OT  - nonconvulsive status epilepticus
OT  - pediatric
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/16 06:01
PMCR- 2022/08/07
CRDT- 2022/08/15 04:15
PHST- 2022/05/27 00:00 [received]
PHST- 2022/07/07 00:00 [revised]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/15 04:15 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/16 06:01 [medline]
PHST- 2022/08/07 00:00 [pmc-release]
AID - 10.1177_2329048X221119575 [pii]
AID - 10.1177/2329048X221119575 [doi]
PST - epublish
SO  - Child Neurol Open. 2022 Aug 7;9:2329048X221119575. doi: 
      10.1177/2329048X221119575. eCollection 2022 Jan-Dec.