PMID- 35969116
OWN - NLM
STAT- MEDLINE
DCOM- 20220817
LR  - 20220921
IS  - 2190-6009 (Electronic)
IS  - 2190-5991 (Print)
IS  - 2190-5991 (Linking)
VI  - 13
IP  - 3
DP  - 2022 Jun
TI  - Step-by-step diagnosis and management of the nocebo/drucebo effect in 
      statin-associated muscle symptoms patients: a position paper from the 
      International Lipid Expert Panel (ILEP).
PG  - 1596-1622
LID - 10.1002/jcsm.12960 [doi]
AB  - Statin intolerance is a clinical syndrome whereby adverse effects (AEs) 
      associated with statin therapy [most commonly statin-associated muscle symptoms 
      (SAMS)] result in the discontinuation of therapy and consequently increase the 
      risk of adverse cardiovascular outcomes. However, complete statin intolerance 
      occurs in only a small minority of treated patients (estimated prevalence of only 
      3-5%). Many perceived AEs are misattributed (e.g. physical musculoskeletal injury 
      and inflammatory myopathies), and subjective symptoms occur as a result of the 
      fact that patients expect them to do so when taking medicines (the nocebo/drucebo 
      effect)-what might be truth even for over 50% of all patients with muscle 
      weakness/pain. Clear guidance is necessary to enable the optimal management of 
      plasma in real-world clinical practice in patients who experience subjective AEs. 
      In this Position Paper of the International Lipid Expert Panel (ILEP), we present 
      a step-by-step patient-centred approach to the identification and management of 
      SAMS with a particular focus on strategies to prevent and manage the 
      nocebo/drucebo effect and to improve long-term compliance with lipid-lowering 
      therapy.
CI  - (c) 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John 
      Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting 
      Disorders.
FAU - Penson, Peter E
AU  - Penson PE
AD  - School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, 
      Liverpool, UK.
AD  - Liverpool Centre for Cardiovascular Science, Liverpool, UK.
FAU - Bruckert, Eric
AU  - Bruckert E
AD  - Pitie-Salpetriere Hospital and Sorbonne University, Cardio metabolic Institute, 
      Paris, France.
FAU - Marais, David
AU  - Marais D
AD  - Chemical Pathology Division of the Department of Pathology, University of Cape 
      Town Health Science Faculty, Cape Town, South Africa.
FAU - Reiner, Zeljko
AU  - Reiner Z
AD  - Department of Internal Medicine, University Hospital Centre Zagreb, School of 
      Medicine University of Zagreb, Zagreb, Croatia.
FAU - Pirro, Matteo
AU  - Pirro M
AD  - Department of Medicine, University of Perugia, Perugia, Italy.
FAU - Sahebkar, Amirhossein
AU  - Sahebkar A
AD  - Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Clinic of Cardiology, University Clinical Centre of Kosova, Medical Faculty, 
      University of Prishtina, Prishtina, Kosovo.
FAU - Bajraktari, Gani
AU  - Bajraktari G
AD  - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
AD  - Department of Internal Disease, Kyrgyz State Medical Academy, Bishkek, 
      Kyrgyzstan.
FAU - Mirrakhimov, Erkin
AU  - Mirrakhimov E
AD  - Department of Atherosclerosis and Coronary Heart Disease, National Center of 
      Cardiology and Internal Diseases, Bishkek, Kyrgyzstan.
FAU - Rizzo, Manfredi
AU  - Rizzo M
AD  - Department of Health Promotion Sciences Maternal and Infantile Care, Internal 
      Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, 
      Italy.
AD  - Division of Endocrinology, Diabetes and Metabolism, School of Medicine, 
      University of South Carolina, Columbia, SC, USA.
FAU - Mikhailidis, Dimitri P
AU  - Mikhailidis DP
AD  - Department of Clinical Biochemistry, University College London Medical School, 
      University College London (UCL), London, UK.
FAU - Sachinidis, Alexandros
AU  - Sachinidis A
AD  - Department of Health Promotion Sciences Maternal and Infantile Care, Internal 
      Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, 
      Italy.
AD  - 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle 
      University of Thessaloniki, Thessaloniki, Greece.
FAU - Gaita, Dan
AU  - Gaita D
AD  - Universitatea de Medicina si Farmacie Victor Babes, Timisoara, Romania.
AD  - Clinica de Cardiologie, Institutul de Boli Cardiovasculare Timisoara, Timisoara, 
      Romania.
FAU - Latkovskis, Gustavs
AU  - Latkovskis G
AD  - Pauls Stradins Clinical University Hospital, Riga, Latvia.
AD  - University of Latvia, Riga, Latvia.
FAU - Mazidi, Mohsen
AU  - Mazidi M
AD  - Medical Research Council Population Health Research Unit, University of Oxford, 
      Oxford, UK.
AD  - Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield 
      Department of Population Health, University of Oxford, Oxford, UK.
FAU - Toth, Peter P
AU  - Toth PP
AD  - CGH Medical Center, Sterling, IL, USA.
AD  - Cicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins 
      University School of Medicine, Baltimore, MD, USA.
FAU - Pella, Daniel
AU  - Pella D
AD  - 2nd Department of Cardiology of the East Slovak Institute of Cardiovascular 
      Disease and Faculty of Medicine, PJ Safarik University, Kosice, Slovak Republic.
FAU - Alnouri, Fahad
AU  - Alnouri F
AD  - Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan 
      Cardiac Centre Riyadh, Riyadh, Saudi Arabia.
FAU - Postadzhiyan, Arman
AU  - Postadzhiyan A
AD  - Department of General Medicine, Emergency University Hospital 'St. Anna', Medical 
      University of Sofia, Sofia, Bulgaria.
FAU - Yeh, Hung-I
AU  - Yeh HI
AD  - Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
FAU - Mancini, G B John
AU  - Mancini GBJ
AD  - Department of General Medicine, Emergency University Hospital 'St. Anna', Medical 
      University of Sofia, Sofia, Bulgaria.
FAU - von Haehling, Stephan
AU  - von Haehling S
AD  - Department of Cardiology and Pneumology, Heart Center, University of Gottingen 
      Medical Center, Gottingen, Germany.
AD  - German Center for Cardiovascular Research (DZHK), partner site Gottingen, 
      Gottingen, Germany.
FAU - Banach, Maciej
AU  - Banach M
AUID- ORCID: 0000-0001-6690-6874
AD  - Polish Moother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
AD  - Department of Preventive Cardiology and Lipidology, Medical University of Lodz 
      (MUL), Lodz, Poland.
AD  - Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland.
CN  - International Lipid Expert Panel (ILEP)
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220310
PL  - Germany
TA  - J Cachexia Sarcopenia Muscle
JT  - Journal of cachexia, sarcopenia and muscle
JID - 101552883
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Lipids)
SB  - IM
MH  - Humans
MH  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects
MH  - Lipids
MH  - Muscles
MH  - *Muscular Diseases/chemically induced/diagnosis/therapy
MH  - Nocebo Effect
PMC - PMC9178378
OTO - NOTNLM
OT  - Drucebo effect
OT  - Nocebo effect
OT  - SAMS
OT  - Statin intolerance
COIS- Peter E. Penson has received honoraria and/or travel reimbursement for events 
      sponsored by AKCEA, Amgen, AMRYT, Link Medical, Mylan, Napp, Sanofi; Eric 
      Bruckert: speakers bureau: Servier, Mylan, Sanofi, Amgen, Akcea; consultant to 
      Amgen, MSD, Sanofi, Novartis, Danone, Aegerion, Ionis Pharmaceuticals, Amarin, 
      Akcea, Servier, Mylan, Silence Therpautic; Zeljko Reiner: speakers bureau: 
      Sanofi, Novartis; Gani Bajraktari: speakers bureau: KRKA; Manfredi Rizzo: 
      speakers bureau: Amgen, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Meda, 
      Mylan, Merck Sharp & Dohme, Novo Nordisk, Roche Diagnostics, Sanofi, and Servier; 
      consultant to Amgen, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Meda, Mylan, 
      Merck Sharp & Dohme, Novo Nordisk, Roche Diagnostics, Sanofi, and Servier; 
      Medical and Scientific Advisor, Europe East and South at Novo Nordisk; Dimitri P. 
      Mikhailidis has given talks, acted as a consultant or attended conferences 
      sponsored by Amgen and Novo Nordisk; Gustavs Latkovskis: speakers bureau: Abbott 
      Laboratories, Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, Grindex, 
      Medtronic, Mylan, Novartis, Novo Nordisk, Pfizer, Roche, Sanofi, Servier, Siemens 
      Laboratories, Zentiva; consultant to Amgen, Bayer, Boehringer Ingelheim, Grindex, 
      Novartis, Novo Nordisk, Sanofi, Servier; Peter P. Toth: speakers bureau: Amgen, 
      Esperion, Kowa, Merck, Novo-Nordisk; consultant to Amarin, bio89, Kowa, Merck, 
      Resverlogix, Theravance; Daniel Pella: received honoraria for events sponsored by 
      Amgen, Jamieson, Novartis, MSD, Pfizer, Servier; Fahad Alnouri is in advisory 
      board and giving lectures supported by Amgen, AMRYT Pharma and Novartis; Stephan 
      von Haehling: has been a paid consultant for and/or received honoraria payments 
      from AstraZeneca, Bayer, Boehringer Ingelheim, BRAHMS, Chugai, Grunenthal, 
      Helsinn, Hexal, Novartis, Pharmacosmos, Respicardia, Roche, Servier, Sorin, and 
      Vifor. SvH reports research support from Amgen, Boehringer Ingelheim, IMI, and 
      the German Center for Cardiovascular Research (DZHK); Maciej Banach: speakers 
      bureau: Amgen, Herbapol, Kogen, KRKA, Polpharma, Mylan/Viatris, Novartis, 
      Novo-Nordisk, Sanofi-Aventis, Teva, Zentiva; consultant to Amgen, Daichii Sankyo, 
      Esperion, Freia Pharmaceuticals, Novartis, Novo-Nordisk, Polfarmex, 
      Sanofi-Aventis; Grants from Amgen, Mylan/Viatris, Sanofi and Valeant; CMO at Nomi 
      Biotech Corporation Ltd; all other authors have no conflict of interest.
FIR - Acosta, Julio
IR  - Acosta J
FIR - Al-Khnifsawi, Mutaz
IR  - Al-Khnifsawi M
FIR - Alnouri, Fahad
IR  - Alnouri F
FIR - Amar, Fahma
IR  - Amar F
FIR - Atanasov, Atanas G
IR  - Atanasov AG
FIR - Bajraktari, Gani
IR  - Bajraktari G
FIR - Banach, Maciej
IR  - Banach M
FIR - Bhaskar, Sonu
IR  - Bhaskar S
FIR - Bytyci, Ibadete
IR  - Bytyci I
FIR - Bjelakovic, Bojko
IR  - Bjelakovic B
FIR - Bruckert, Eric
IR  - Bruckert E
FIR - Cafferata, Alberto
IR  - Cafferata A
FIR - Ceska, Richard
IR  - Ceska R
FIR - Cicero, Arrigo F G
IR  - Cicero AFG
FIR - Collet, Xavier
IR  - Collet X
FIR - Daccord, Magdalena
IR  - Daccord M
FIR - Descamps, Olivier
IR  - Descamps O
FIR - Djuric, Dragan
IR  - Djuric D
FIR - Durst, Ronen
IR  - Durst R
FIR - Ezhov, Marat V
IR  - Ezhov MV
FIR - Fras, Zlatko
IR  - Fras Z
FIR - Gaita, Dan
IR  - Gaita D
FIR - Hernandez, Adrian V
IR  - Hernandez AV
FIR - Jones, Steven R
IR  - Jones SR
FIR - Jozwiak, Jacek
IR  - Jozwiak J
FIR - Kakauridze, Nona
IR  - Kakauridze N
FIR - Kallel, Amani
IR  - Kallel A
FIR - Katsiki, Niki
IR  - Katsiki N
FIR - Khera, Amit
IR  - Khera A
FIR - Kostner, Karam
IR  - Kostner K
FIR - Kubilius, Raimondas
IR  - Kubilius R
FIR - Latkovskis, Gustavs
IR  - Latkovskis G
FIR - Mancini, G B John
IR  - Mancini GBJ
FIR - Marais, A David
IR  - Marais AD
FIR - Martin, Seth S
IR  - Martin SS
FIR - Martinez, Julio Acosta
IR  - Martinez JA
FIR - Mazidi, Mohsen
IR  - Mazidi M
FIR - Mikhailidis, Dimitri P
IR  - Mikhailidis DP
FIR - Mirrakhimov, Erkin
IR  - Mirrakhimov E
FIR - Miserez, Andre R
IR  - Miserez AR
FIR - Mitchenko, Olena
IR  - Mitchenko O
FIR - Mitkovskaya, Natalya P
IR  - Mitkovskaya NP
FIR - Moriarty, Patrick M
IR  - Moriarty PM
FIR - Nabavi, Seyed Mohammad
IR  - Nabavi SM
FIR - Nair, Devaki
IR  - Nair D
FIR - Panagiotakos, Demosthenes B
IR  - Panagiotakos DB
FIR - Paragh, Gyorgy
IR  - Paragh G
FIR - Pella, Daniel
IR  - Pella D
FIR - Penson, Peter E
IR  - Penson PE
FIR - Petrulioniene, Zaneta
IR  - Petrulioniene Z
FIR - Pirro, Matteo
IR  - Pirro M
FIR - Postadzhiyan, Arman
IR  - Postadzhiyan A
FIR - Puri, Raman
IR  - Puri R
FIR - Reda, Ashraf
IR  - Reda A
FIR - Reiner, Zeljko
IR  - Reiner Z
FIR - Radenkovic, Dina
IR  - Radenkovic D
FIR - Rakowski, Michal
IR  - Rakowski M
FIR - Riadh, Jemaa
IR  - Riadh J
FIR - Richter, Dimitri
IR  - Richter D
FIR - Rizzo, Manfredi
IR  - Rizzo M
FIR - Ruscica, Massimiliano
IR  - Ruscica M
FIR - Sahebkar, Amirhossein
IR  - Sahebkar A
FIR - Sattar, Naveed
IR  - Sattar N
FIR - Serban, Maria-Corina
IR  - Serban MC
FIR - Shehab, Abdullah M A
IR  - Shehab AMA
FIR - Shek, Aleksandr B
IR  - Shek AB
FIR - Sirtori, Cesare R
IR  - Sirtori CR
FIR - Stefanutti, Claudia
IR  - Stefanutti C
FIR - Tomasik, Tomasz
IR  - Tomasik T
FIR - Toth, Peter P
IR  - Toth PP
FIR - Viigimaa, Margus
IR  - Viigimaa M
FIR - Valdivielso, Pedro
IR  - Valdivielso P
FIR - Vinereanu, Dragos
IR  - Vinereanu D
FIR - Vohnout, Branislav
IR  - Vohnout B
FIR - von Haehling, Stephan
IR  - von Haehling S
FIR - Vrablik, Michal
IR  - Vrablik M
FIR - Wong, Nathan D
IR  - Wong ND
FIR - Yeh, Hung-I
IR  - Yeh HI
FIR - Zhisheng, Jiang
IR  - Zhisheng J
FIR - Zirlik, Andreas
IR  - Zirlik A
EDAT- 2022/08/16 06:00
MHDA- 2022/08/18 06:00
PMCR- 2022/06/01
CRDT- 2022/08/15 09:22
PHST- 2022/01/17 00:00 [revised]
PHST- 2021/12/08 00:00 [received]
PHST- 2022/02/01 00:00 [accepted]
PHST- 2022/08/15 09:22 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/18 06:00 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - JCSM12960 [pii]
AID - 10.1002/jcsm.12960 [doi]
PST - ppublish
SO  - J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1596-1622. doi: 10.1002/jcsm.12960. 
      Epub 2022 Mar 10.