PMID- 35971173
OWN - NLM
STAT- MEDLINE
DCOM- 20220817
LR  - 20220819
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Aug 15
TI  - Impact of chronic obstructive pulmonary disease on short-term outcome in patients 
      with ST-elevation myocardial infarction during COVID-19 pandemic: insights from 
      the international multicenter ISACS-STEMI registry.
PG  - 207
LID - 10.1186/s12931-022-02128-0 [doi]
LID - 207
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become 
      the third cause of mortality worldwide. COPD shares several pathophysiological 
      mechanisms with cardiovascular disease, especially atherosclerosis. However, no 
      definite answers are available on the prognostic role of COPD in the setting of 
      ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, 
      among patients undergoing primary angioplasty, that is therefore the aim of the 
      current study. METHODS: In the ISACS-STEMI COVID-19 registry we included 
      retrospectively patients with STEMI treated with primary percutaneous coronary 
      intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume 
      primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were 
      included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. 
      They were more often elderly and with a more pronounced cardiovascular risk 
      profile. No preminent procedural dissimilarities were noticed except for a lower 
      proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% 
      vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both 
      in-hospital and 30-days mortality occurred more frequently among COPD patients, 
      similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main 
      baseline differences, COPD did not result as independent predictor for 
      in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 
      30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No 
      significant differences were detected in terms of SARS-CoV-2 positivity between 
      the two groups. CONCLUSION: This is one of the largest studies investigating 
      characteristics and outcome of COPD patients with STEMI undergoing primary 
      angioplasty, especially during COVID pandemic. COPD was associated with 
      significantly higher rates of in-hospital and 30-days mortality. However, this 
      association disappeared after adjustment for baseline characteristics. 
      Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL 
      REGISTRATION NUMBER: NCT04412655 (2nd June 2020).
CI  - (c) 2022. The Author(s).
FAU - De Luca, Giuseppe
AU  - De Luca G
AD  - Division of Clinical and Experimental Cardiology, AOU Sassari, Sassari, Italy. 
      gdeluca@uniss.it.
AD  - University of Sassari, Sassari, Italy. gdeluca@uniss.it.
FAU - Nardin, Matteo
AU  - Nardin M
AD  - Third Medicine Division, ASST Spedali Civili, Brescia, Italy.
FAU - Algowhary, Magdy
AU  - Algowhary M
AD  - Division of Cardiology, Assiut University Heart Hospital, Assiut University, 
      Asyut, Egypt.
FAU - Uguz, Berat
AU  - Uguz B
AD  - Division of Cardiology, Bursa City Hospital, Bursa, Turkey.
FAU - Oliveira, Dinaldo C
AU  - Oliveira DC
AD  - Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal 
      University of Pernambuco, Recife, Brazil.
FAU - Ganyukov, Vladimir
AU  - Ganyukov V
AD  - Department of Heart and Vascular Surgery, State Research Institute for Complex 
      Issues of Cardiovascular Diseases, Kemerovo, Russia.
FAU - Zimbakov, Zan
AU  - Zimbakov Z
AD  - Medical Faculty, University Clinic for Cardiology, Ss' Cyril and Methodius 
      University, Skopje, North Macedonia.
FAU - Cercek, Miha
AU  - Cercek M
AD  - Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, 
      Slovenia.
FAU - Okkels Jensen, Lisette
AU  - Okkels Jensen L
AD  - Division of Cardiology, Odense Universitets Hospital, Odense, Danemark.
FAU - Loh, Poay Huan
AU  - Loh PH
AD  - Department of Cardiology, National University Hospital, Singapore, Singapore.
FAU - Calmac, Lucian
AU  - Calmac L
AD  - Clinic Emergency Hospital of Bucharest, Bucharest, Romania.
FAU - Roura Ferrer, Gerard
AU  - Roura Ferrer G
AD  - Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de 
      Bellvitge, Barcelona, Spain.
FAU - Quadros, Alexandre
AU  - Quadros A
AD  - Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Milewski, Marek
AU  - Milewski M
AD  - Division of Cardiology, Medical University of Silezia, Katowice, Poland.
FAU - Scotto di Uccio, Fortunato
AU  - Scotto di Uccio F
AD  - Division of Cardiology, Ospedale del Mare, Naples, Italy.
FAU - von Birgelen, Clemens
AU  - von Birgelen C
AD  - Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 
      Enschede, The Netherlands.
FAU - Versaci, Francesco
AU  - Versaci F
AD  - Division of Cardiology, Ospedale Santa Maria Goretti Latina, Latina, Italy.
FAU - Ten Berg, Jurrien
AU  - Ten Berg J
AD  - Division of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.
FAU - Casella, Gianni
AU  - Casella G
AD  - Division of Cardiology, Ospedale Maggiore Bologna, Bologna, Italy.
FAU - Wong Sung Lung, Aaron
AU  - Wong Sung Lung A
AD  - Department of Cardiology, National Heart Center, Singapore, Singapore.
FAU - Kala, Petr
AU  - Kala P
AD  - University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech 
      Republic.
FAU - Diez Gil, Jose Luis
AU  - Diez Gil JL
AD  - H. Universitario y Politecnico La Fe, Valencia, Spain.
FAU - Carrillo, Xavier
AU  - Carrillo X
AD  - Hospital Germans Triasi Pujol, Badalona, Spain.
FAU - Dirksen, Maurits
AU  - Dirksen M
AD  - Division of Cardiology, Northwest Clinics, Alkmaar, The Netherlands.
FAU - Becerra-Munoz, Victor M
AU  - Becerra-Munoz VM
AD  - Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain.
FAU - Lee, Michael Kang-Yin
AU  - Lee MK
AD  - Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Yau 
      Ma Tei, Hong Kong.
FAU - Arifa Juzar, Dafsah
AU  - Arifa Juzar D
AD  - Department of Cardiology and Vascular Medicine, University of Indonesia National 
      Cardiovascular Center "Harapan Kita", Jakarta, Indonesia.
FAU - de Moura Joaquim, Rodrigo
AU  - de Moura Joaquim R
AD  - Instituto de Cardiologia de Santa Catarina Praia Comprida, Sao Jose, Brasil.
FAU - Paladino, Roberto
AU  - Paladino R
AD  - Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy.
FAU - Milicic, Davor
AU  - Milicic D
AD  - Department of Cardiology, University Hospital Centre, University of Zagreb, 
      Zagreb, Croatia.
FAU - Davlouros, Periklis
AU  - Davlouros P
AD  - Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 
      Patras, Greece.
FAU - Bakraceski, Nikola
AU  - Bakraceski N
AD  - Center for Cardiovascular Diseases, Ohrid, North Macedonia.
FAU - Zilio, Filippo
AU  - Zilio F
AD  - Division of Cardiology, Ospedale Santa Chiara di Trento, Trento, Italy.
FAU - Donazzan, Luca
AU  - Donazzan L
AD  - Division of Cardiology, Ospedale "S. Maurizio" Bolzano, Bolzano, Italy.
FAU - Kraaijeveld, Adriaan
AU  - Kraaijeveld A
AD  - Division of Cardiology, UMC Utrecht, Utrecht, The Netherlands.
FAU - Galasso, Gennaro
AU  - Galasso G
AD  - Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, 
      Italy.
FAU - Lux, Arpad
AU  - Lux A
AD  - Maastricht University Medical Center, Maastricht, The Netherlands.
FAU - Marinucci, Lucia
AU  - Marinucci L
AD  - Division of Cardiology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", 
      Pesaro, Italy.
FAU - Guiducci, Vincenzo
AU  - Guiducci V
AD  - Division of Cardiology, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.
FAU - Menichelli, Maurizio
AU  - Menichelli M
AD  - Division of Cardiology, Ospedale "F. Spaziani", Frosinone, Italy.
FAU - Scoccia, Alessandra
AU  - Scoccia A
AD  - Division of Cardiology, Ospedale "Sant'Anna", Ferrara, Italy.
FAU - Yamac, Aylin Hatice
AU  - Yamac AH
AD  - Department of Cardiology, Hospital Bezmialem Vakif University, Istanbul, Turkey.
FAU - Ugur Mert, Kadir
AU  - Ugur Mert K
AD  - Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 
      Eskisehir, Turkey.
FAU - Flores Rios, Xacobe
AU  - Flores Rios X
AD  - Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.
FAU - Kovarnik, Tomas
AU  - Kovarnik T
AD  - University Hospital Prague, Prague, Czech Republic.
FAU - Kidawa, Michal
AU  - Kidawa M
AD  - Central Hospital of Medical University of Lodz, Lodz, Poland.
FAU - Moreu, Jose
AU  - Moreu J
AD  - Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain.
FAU - Flavien, Vincent
AU  - Flavien V
AD  - Division of Cardiology, Center Hospitalier Universitaire de Lille, Lille, France.
FAU - Fabris, Enrico
AU  - Fabris E
AD  - Azienda Ospedaliero-Universitaria Ospedali Riuniti Trieste, Trieste, Italy.
FAU - Martinez-Luengas, Inigo Lozano
AU  - Martinez-Luengas IL
AD  - Division of Cardiology, Hospital Cabuenes, Gijon, Spain.
FAU - Boccalatte, Marco
AU  - Boccalatte M
AD  - Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy.
FAU - Bosa Ojeda, Francisco
AU  - Bosa Ojeda F
AD  - Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de 
      Tenerife, Spain.
FAU - Arellano-Serrano, Carlos
AU  - Arellano-Serrano C
AD  - Division of Cardiology, Hospital Puerta de Hierro Majadahonda, Madrid, Spain.
FAU - Caiazzo, Gianluca
AU  - Caiazzo G
AD  - Division of Cardiology, Ospedale "G Moscati", Aversa, Italy.
FAU - Cirrincione, Giuseppe
AU  - Cirrincione G
AD  - Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.
FAU - Kao, Hsien-Li
AU  - Kao HL
AD  - Cardiology Division, Department of Internal Medicine, National Taiwan University 
      Hospital, Tapei, Taiwan.
FAU - Sanchis Fores, Juan
AU  - Sanchis Fores J
AD  - Division of Cardiology, Hospital Clinico Universitario de Valencia, Valencia, 
      Spain.
FAU - Vignali, Luigi
AU  - Vignali L
AD  - Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.
FAU - Pereira, Helder
AU  - Pereira H
AD  - Cardiology Department, Hospital Garcia de Orta, Pragal, Almada, Portugal.
FAU - Manzo, Stephane
AU  - Manzo S
AD  - Division of Cardiology, CHU Lariboisiere, AP-HP, Paris VII University, INSERM 
      UMRS 942, Paris, France.
FAU - Ordonez, Santiago
AU  - Ordonez S
AD  - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.
FAU - Ozkan, Alev Arat
AU  - Ozkan AA
AD  - Cardiology Institute, Istanbul University, Istanbul, Turkey.
FAU - Scheller, Bruno
AU  - Scheller B
AD  - Division of Cardiology Clinical and Experimental Interventional Cardiology, 
      University of Saarland, Saarbrucken, Germany.
FAU - Lehtola, Heidi
AU  - Lehtola H
AD  - Division of Cardiology, Oulu University Hospital, Oulu, Finland.
FAU - Teles, Rui
AU  - Teles R
AD  - Division of Cardiology, Hospital de Santa Cruz, CHLO-Nova Medical School, CEDOC, 
      Lisbon, Portugal.
FAU - Mantis, Christos
AU  - Mantis C
AD  - Division of Cardiology, Kontantopoulion Hospital, Athens, Greece.
FAU - Antti, Ylitalo
AU  - Antti Y
AD  - Division of Cardiology, Heart Centre Turku, Turku, Finland.
FAU - Brum Silveira, Joao A
AU  - Brum Silveira JA
AD  - Division of Cardiology, Hospital de Santo Antonio, Porto, Portugal.
FAU - Zoni, Rodrigo
AU  - Zoni R
AD  - Department of Teaching and Research, Instituto de Cardiologia de Corrientes 
      "Juana F. Cabral", Corrientes, Argentina.
FAU - Bessonov, Ivan
AU  - Bessonov I
AD  - Tyumen Cardiology Research Center, Tyumen, Russia.
FAU - Savonitto, Stefano
AU  - Savonitto S
AD  - Division of Cardiology, Ospedale "A. Manzoni", Lecco, Italy.
FAU - Kochiadakis, George
AU  - Kochiadakis G
AD  - Iraklion University Hospital, Crete, Greece.
FAU - Alexopoulos, Dimitrios
AU  - Alexopoulos D
AD  - Division of Cardiology, Attikon University Hospital, Athens, Greece.
FAU - Uribe, Carlos E
AU  - Uribe CE
AD  - Division of Cardiology, Universidad UPB, Universidad CES, Medellin, Colombia.
FAU - Kanakakis, John
AU  - Kanakakis J
AD  - Division of Cardiology, Alexandra Hospital, Athens, Greece.
FAU - Faurie, Benjamin
AU  - Faurie B
AD  - Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, 
      France.
FAU - Gabrielli, Gabriele
AU  - Gabrielli G
AD  - Interventional Cardiology Unit, Azienda Ospedaliero Universitaria"Ospedali 
      Riuniti", Ancona, Italy.
FAU - Gutierrez Barrios, Alejandro
AU  - Gutierrez Barrios A
AD  - Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain.
FAU - Bachini, Juan Pablo
AU  - Bachini JP
AD  - Instituto de Cardiologia Integral, Montevideo, Uruguay.
FAU - Rocha, Alex
AU  - Rocha A
AD  - Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de 
      Cirugia Cardiaca, Montevideo, Uruguay.
FAU - Tam, Frankie Chor-Cheung
AU  - Tam FC
AD  - Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Pok Fu 
      Lam, Hong Kong.
FAU - Rodriguez, Alfredo
AU  - Rodriguez A
AD  - Division of Cardiology, Otamendi Hospital, Buenos Aires, Argentina.
FAU - Lukito, Antonia Anna
AU  - Lukito AA
AD  - Cardiovascular Department Pelita, Harapan University/Heart Center Siloam Lippo 
      Village Hospital, Tangerang, Banten, Indonesia.
FAU - Saint-Joy, Veauthyelau
AU  - Saint-Joy V
AD  - Center Hospitalier d'Antibes Juan Les Pins, Antibes, France.
FAU - Pessah, Gustavo
AU  - Pessah G
AD  - Division of Cardiology, Hospiatl Cordoba, Cordoba, Argentina.
FAU - Tuccillo, Andrea
AU  - Tuccillo A
AD  - Division of Cardiology, Ospedale del Mare, Naples, Italy.
FAU - Cortese, Giuliana
AU  - Cortese G
AD  - Department of Statistical Sciences, University of Padova, Padua, Italy.
FAU - Parodi, Guido
AU  - Parodi G
AD  - Department of Cardiology, ASL 4 Liguria, Lavagna, Italy.
FAU - Bouraghda, Mohamed Abed
AU  - Bouraghda MA
AD  - Division of Cardiology, Blida University Hospital, Blida, Algeria.
FAU - Kedhi, Elvin
AU  - Kedhi E
AD  - Division of Cardiology, Hopital Erasmus, Universite Libre de Bruxelles, Brussels, 
      Belgium.
FAU - Lamelas, Pablo
AU  - Lamelas P
AD  - Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.
FAU - Suryapranata, Harry
AU  - Suryapranata H
AD  - Division of Cardiology, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Verdoia, Monica
AU  - Verdoia M
AD  - Division of Cardiology, Ospedale degli Infermi, ASL Biella, Ponderano, Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT04412655
PT  - Journal Article
PT  - Multicenter Study
DEP - 20220815
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
SB  - IM
MH  - Aged
MH  - *COVID-19/epidemiology
MH  - Hospital Mortality
MH  - Humans
MH  - Pandemics
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - *Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology/therapy
MH  - Registries
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - *ST Elevation Myocardial Infarction/diagnosis/epidemiology/therapy
MH  - Treatment Outcome
PMC - PMC9376902
OTO - NOTNLM
OT  - COPD
OT  - Mortality
OT  - STEMI
COIS- All authors have reported that they have no relationships relevant to the 
      contents of this paper to disclose.
EDAT- 2022/08/16 06:00
MHDA- 2022/08/18 06:00
PMCR- 2022/08/15
CRDT- 2022/08/15 23:38
PHST- 2022/01/08 00:00 [received]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/08/15 23:38 [entrez]
PHST- 2022/08/16 06:00 [pubmed]
PHST- 2022/08/18 06:00 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
AID - 10.1186/s12931-022-02128-0 [pii]
AID - 2128 [pii]
AID - 10.1186/s12931-022-02128-0 [doi]
PST - epublish
SO  - Respir Res. 2022 Aug 15;23(1):207. doi: 10.1186/s12931-022-02128-0.