PMID- 35972654
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230206
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 2
DP  - 2023 Jan
TI  - Associations of exposure to multiple metals with the risk of age-related cataract 
      in Anhui, China: a case-control study.
PG  - 4680-4693
LID - 10.1007/s11356-022-22494-y [doi]
AB  - It's well-known that multiple metal elements can lead to the change of oxidative 
      stress response levels in vivo. However, their relationship with age-related 
      cataract (ARC) had not been well studied. We designed a case-control study 
      including 210 individuals with ARC and 210 matched control group. The metal 
      levels in their urine specimens were measured using graphite furnace atomic 
      absorption spectrometry (GFAAS) and inductively coupled plasma optical emission 
      spectrometry (ICP-OES). Least Absolute Shrinkage and Selection Operator (LASSO) 
      regression was used to select representative metals into the multi-element model 
      and reduce dimension. Multivariate logic analysis and Bayesian kernel machine 
      regression (BKMR) were subsequently used to explore the association of ARC risk 
      with multiple metal elements. We found that magnesium (Mg), chromium (Cr), 
      arsenic (As), manganese (Mn), and selenium (Se) were positively associated with 
      ARC in the single-element model. The multiple exposure model indicated a positive 
      association between Mg and As, in which the OR in their highest quartile were 
      3.32 (95% CI: 1.24-8.89) and 7.09 (95% CI: 2.56-19.63). The BKMR model also 
      showed the effect of As increased monotonically with its increasing 
      concentration, and high levels of Mg and As had a significant positive effect on 
      ARC risk. In conclusion, we found that exposure to multiple metals was associated 
      with increased ARC risk. Further research is needed to verify these findings in 
      the future.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Li, Yan-Qing
AU  - Li YQ
AD  - Department of Ophthalmology, First Affiliated Hospital of Anhui Medical 
      University, No.218, Jixi Road, Shushan District, Hefei, 230022, Anhui, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Ophthalmology, First Affiliated Hospital of Anhui Medical 
      University, No.218, Jixi Road, Shushan District, Hefei, 230022, Anhui, China.
FAU - Liu, Ran
AU  - Liu R
AD  - Department of Ophthalmology, First Affiliated Hospital of Anhui Medical 
      University, No.218, Jixi Road, Shushan District, Hefei, 230022, Anhui, China.
FAU - Li, Guo-Ao
AU  - Li GA
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - He, Jia-Liu
AU  - He JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Huang, Fen
AU  - Huang F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Zhou, Yan-Feng
AU  - Zhou YF
AD  - Department of Ophthalmology, First Affiliated Hospital of Anhui Medical 
      University, No.218, Jixi Road, Shushan District, Hefei, 230022, Anhui, China. 
      lizzhou@163.com.
LA  - eng
GR  - gxbjZD09/The Project for Top Disciplinary Talents of Majors in Universities of 
      Anhui Province/
PT  - Journal Article
DEP - 20220816
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Metals)
RN  - H6241UJ22B (Selenium)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Metals
MH  - *Selenium
MH  - *Arsenic
MH  - China/epidemiology
OTO - NOTNLM
OT  - Age-related cataract
OT  - BKMR analysis
OT  - Case-control study
OT  - Environmental pollution
OT  - Multiple metals
OT  - Risk factors
EDAT- 2022/08/17 06:00
MHDA- 2023/02/07 06:00
CRDT- 2022/08/16 11:20
PHST- 2022/04/05 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/08/17 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2022/08/16 11:20 [entrez]
AID - 10.1007/s11356-022-22494-y [pii]
AID - 10.1007/s11356-022-22494-y [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Jan;30(2):4680-4693. doi: 
      10.1007/s11356-022-22494-y. Epub 2022 Aug 16.