PMID- 35973458
OWN - NLM
STAT- MEDLINE
DCOM- 20220914
LR  - 20220929
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 214
IP  - Pt 3
DP  - 2022 Nov
TI  - Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose 
      tissues and blood lipids in women of Shantou, China.
PG  - 114096
LID - S0013-9351(22)01423-2 [pii]
LID - 10.1016/j.envres.2022.114096 [doi]
AB  - Animal studies have indicated that exposure to polybrominated diphenyl ethers 
      (PBDEs) during development can permanently affect blood/liver lipid balance. 
      However, no epidemiological study has assessed the relationship between PBDEs in 
      adipose tissues and blood lipid metabolism. In this study, we explored the 
      associations between PBDEs levels in female adipose tissues and lipid profiles. 
      We recruited 150 female patients undergoing plastic surgery from hospital in 
      Shantou, China, collected their characteristics, clinical information, and 
      adipose tissue samples. Fourteen PBDE congeners in adipose tissues were analyzed 
      by gas chromatography-mass spectrometry (GC-MS). Multiple linear and logistic 
      regression models were used to explore the relationships between PBDEs and lipid 
      profiles, while restricted cubic spline (RCS) regression and Bayesian kernel 
      machine regression (BKMR) models were used to evaluate the nonlinearity of 
      mixtures. Median levels of SigmaPBDEs and dominant congeners BDE-153, -209, and -183 
      in adipose tissues were 73.91, 26.12, 14.10 and 9.01 ng/g lipid, respectively. In 
      the multiple linear model, BDE-153 and BDE-209 were negatively associated with 
      triglycerides (TG), similarly for BDE-190 and total cholesterol (TC). While in 
      the adjusted logistic models, BDE-138 was negatively associated with TC 
      (OR = 0.76, 95%CI: 0.58, 0.99) and total lipids (TL) (OR = 0.76, 95%CI: 0.58, 
      0.99). Diastolic blood pressure was positively correlated with BDE-28 and BDE-71 
      (P < 0.05). Furthermore, a non-linear relationship was observed in BDE-138 and 
      blood lipid levels using a RCS model (P(nonlinearity)<0.05). BKMR analysis 
      indicated that with the cumulative levels across PBDEs increased, the health 
      risks of hypertriglyceridemia gradually rebounded, and the health risks of 
      hypercholesterolemia and high total lipid gradually rebounded and then declined, 
      but without statistical significance. PBDEs pollution was still prevalent in 
      Shantou city, and several PBDE congeners were significant risk factors for 
      dyslipidemia and blood pressure alteration. There exist deleterious effects of 
      PBDEs and blood lipids.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Zhang, Qiong
AU  - Zhang Q
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Peng, Jiajun
AU  - Peng J
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Huang, Anyan
AU  - Huang A
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Zheng, Shukai
AU  - Zheng S
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Shi, Xiaoling
AU  - Shi X
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Li, Boyu
AU  - Li B
AD  - Department of Medical Statistics, School of Public Health, Sun Yat-sen 
      University, Guangzhou, 510080, Guangdong, China.
FAU - Huang, Wenlong
AU  - Huang W
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Tan, Wei
AU  - Tan W
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China.
FAU - Wu, Kusheng
AU  - Wu K
AD  - Department of Preventive Medicine, Shantou University Medical College, Shantou, 
      515041, Guangdong, China. Electronic address: kswu@stu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220813
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Lipids)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Bayes Theorem
MH  - China
MH  - *Environmental Monitoring/methods
MH  - Female
MH  - *Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - Lipids
OTO - NOTNLM
OT  - Adipose tissues
OT  - Blood lipids
OT  - Blood pressure
OT  - Liver function
OT  - Polybrominated diphenyl ethers (PBDEs)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/17 06:00
MHDA- 2022/09/15 06:00
CRDT- 2022/08/16 19:23
PHST- 2022/06/22 00:00 [received]
PHST- 2022/08/07 00:00 [revised]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/08/17 06:00 [pubmed]
PHST- 2022/09/15 06:00 [medline]
PHST- 2022/08/16 19:23 [entrez]
AID - S0013-9351(22)01423-2 [pii]
AID - 10.1016/j.envres.2022.114096 [doi]
PST - ppublish
SO  - Environ Res. 2022 Nov;214(Pt 3):114096. doi: 10.1016/j.envres.2022.114096. Epub 
      2022 Aug 13.