PMID- 35974856
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220818
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 7
DP  - 2022 Jul
TI  - Oral Metronidazole Desensitization for Immunoglobulin E (IgE)-Mediated 
      Hypersensitivity.
PG  - e26849
LID - 10.7759/cureus.26849 [doi]
LID - e26849
AB  - Low efficacy has been reported for the treatment of Trichomonas vaginalis with 
      antimicrobial agents other than the 5-nitroimidazole class. Patients with 
      immunoglobulin E (IgE)-mediated hypersensitivity reactions to drugs in this 
      class, including metronidazole and tinidazole, may benefit from a desensitization 
      treatment. We present two patients with past medical histories of IgE-mediated 
      hypersensitivity reactions to metronidazole who were successfully treated with 
      metronidazole using a modified protocol. The first patient was a 39-year-old 
      female diagnosed with trichomoniasis who had a previous reaction to metronidazole 
      characterized by urticaria and pruritus. The second patient was a 53-year-old 
      female who had a history of untreated trichomoniasis due to a previous 
      anaphylactic reaction to metronidazole. Both patients were successfully treated 
      in the intensive care unit (ICU) without signs and symptoms of the reaction. 
      Physicians may use a desensitization protocol for patients with a presumed 
      IgE-mediated hypersensitivity when only the 5-nitroimidazole class is efficacious 
      for the treatment of trichomoniasis.
CI  - Copyright (c) 2022, Hollis et al.
FAU - Hollis, Chantae C
AU  - Hollis CC
AD  - Internal Medicine, Bermuda Hospitals Board, Paget, BMU.
AD  - Medicine, John F. Kennedy University School of Medicine, Willemstad, CUW.
FAU - Mlauzi, Chamunorwa
AU  - Mlauzi C
AD  - Pharmacy, Bermuda Hospitals Board, Paget, BMU.
FAU - Ashton, Michael
AU  - Ashton M
AD  - Infection & Diseases, Bermuda Hospitals Board, Paget, BMU.
LA  - eng
PT  - Case Reports
DEP - 20220714
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9375180
OTO - NOTNLM
OT  - allergic hypersensitivity
OT  - desensitization
OT  - metronidazole
OT  - sexually transmitted infection (sti)
OT  - trichomoniasis
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/08/18 06:00
MHDA- 2022/08/18 06:01
PMCR- 2022/07/14
CRDT- 2022/08/17 01:55
PHST- 2022/07/14 00:00 [accepted]
PHST- 2022/08/17 01:55 [entrez]
PHST- 2022/08/18 06:00 [pubmed]
PHST- 2022/08/18 06:01 [medline]
PHST- 2022/07/14 00:00 [pmc-release]
AID - 10.7759/cureus.26849 [doi]
PST - epublish
SO  - Cureus. 2022 Jul 14;14(7):e26849. doi: 10.7759/cureus.26849. eCollection 2022 
      Jul.