PMID- 35975257
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220818
IS  - 1841-0987 (Print)
IS  - 1843-066X (Electronic)
IS  - 1841-0987 (Linking)
VI  - 18
IP  - 1
DP  - 2022 Jan-Mar
TI  - COULD PROTEINURIA PREDICT THE RENAL PROGNOSES OF PATIENTS WITH TYPE 2 DIABETES 
      MELLITUS AND DIABETIC NEPHROPATHY?
PG  - 29-34
LID - 10.4183/aeb.2022.29 [doi]
AB  - AIMS: This study investigated the relationship between proteinuria levels, 
      clinicopathological features, and renal prognoses in Chinese patients with type 2 
      diabetes mellitus (T2DM) and diabetic nephropathy (DN). METHODS: Three hundred 
      patients with T2DM and biopsy-proven DN were enrolled. Patients were stratified 
      by 24-h proteinuria levels: Group 1:</=1g/24h); Group 2:1-3g/24h; and Group 
      3:>/=3g/24h. Renal outcomes were defined as having reached end-stage renal disease 
      (ESRD). The proteinuria level's influence on the renal outcomes was evaluated 
      using Cox regression analysis. RESULTS: Among subgroups stratified by proteinuria 
      levels, systolic blood pressure, serum creatinine, BUN, cholesterol, DR and 
      hypertension incidence, the incidences of patients who progressed to ESRD were 
      the lowest in group 1 (P<0.05). However, eGFR, serum albumin and hemoglobin were 
      highest in group 1. Patients with higher proteinuria levels had much lower 
      five-year renal survival rates. Univariate analyses revealed that higher 
      proteinuria levels were significant clinical predictors of renal prognosis 
      (P<0.05), although they were not independent risk factors for progression to ESRD 
      in the multivariate Cox proportional hazard analysis (P>0.05). CONCLUSIONS: The 
      higher the level of proteinuria, the lower the 5-year renal survival rate of DN 
      patients, but there was no significant correlation between proteinuria level and 
      5-year renal survival rate. Other factors in the proteinuria group may have more 
      significant effects on the 5-year renal survival rate, such as lower baseline 
      eGFR, serum albumin, hemoglobin and higher cholesterol, higher incidences of DR 
      and more severe lesions.
CI  - (c)2021 Acta Endocrinologica (Buc).
FAU - Wang, J L
AU  - Wang JL
AD  - West China Hospital of Sichuan University, Division of Nephrology, Chengdu, 
      China.
AD  - Mianyang Central Hospital, Division of Nephrology, Mianyang, China.
FAU - Sun, Y
AU  - Sun Y
AD  - West China Hospital of Sichuan University, Division of Nephrology, Chengdu, 
      China.
FAU - Wang, Y
AU  - Wang Y
AD  - West China Hospital of Sichuan University, Division of Nephrology, Chengdu, 
      China.
FAU - Wu, Y
AU  - Wu Y
AD  - West China Hospital of Sichuan University, Division of Nephrology, Chengdu, 
      China.
FAU - Liu, F
AU  - Liu F
AD  - West China Hospital of Sichuan University, Division of Nephrology, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Acta Endocrinol (Buchar)
JT  - Acta endocrinologica (Bucharest, Romania : 2005)
JID - 101269720
PMC - PMC9365414
OTO - NOTNLM
OT  - clinico-pathological features
OT  - diabetic nephropathy
OT  - prognoses
OT  - proteinuria
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/08/18 06:00
MHDA- 2022/08/18 06:01
PMCR- 2022/07/01
CRDT- 2022/08/17 02:03
PHST- 2022/08/17 02:03 [entrez]
PHST- 2022/08/18 06:00 [pubmed]
PHST- 2022/08/18 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - aeb.2022.029 [pii]
AID - 10.4183/aeb.2022.29 [doi]
PST - ppublish
SO  - Acta Endocrinol (Buchar). 2022 Jan-Mar;18(1):29-34. doi: 10.4183/aeb.2022.29.