PMID- 35975317
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230828
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 33
IP  - 5
DP  - 2023 Aug 25
TI  - Reasons and risk factors for discontinuation of treatment with any biological 
      disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A 
      long-term observational study.
PG  - 891-898
LID - 10.1093/mr/roac090 [doi]
AB  - OBJECTIVES: Patients with rheumatoid arthritis (RA) usually switch to a second 
      biological disease-modifying antirheumatic drugs (bDMARDs) when the first has 
      proven to be ineffective, although some may discontinue bDMARDs treatment 
      altogether. We investigated the total rate of bDMARDs retention and the risk of 
      bDMARDs discontinuation in patients with RA. METHODS: The study included 564 
      patients with RA who started bDMARDs treatment before 2008 (<65 years old, 
      n = 413; >/=65, n = 151). The primary outcome was the incidence of bDMARDs 
      discontinuation due to adverse events (AEs). Risk factors were examined using 
      Fine and Gray regression models. RESULTS: Among 564 patients, 74 had discontinued 
      bDMARDs treatment due to AEs. Male sex and Steinbrocker class 3-4 were more 
      frequent, while rheumatoid factor and concomitant methotrexate treatment were 
      less frequent, in those aged >/=65 years than in those aged <65 years, 
      respectively. The subdistribution hazard ratio for discontinuation was 
      significantly higher in the >/=65 group than in the <65 years group (hazard 
      ratio = 3.53, 95% confidence interval = 2.07-6.03). Lack of concomitant treatment 
      with MTX was risk factor for discontinuation in patients >/=65 years. Advanced 
      Steinbrocker class was a risk factor in patients <65 years. CONCLUSIONS: Older 
      patients are at higher risk of discontinuing bDMARDs treatment due to AEs than 
      younger patients.
CI  - (c) Japan College of Rheumatology 2022. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Terabe, Kenya
AU  - Terabe K
AUID- ORCID: 0000-0001-6469-1312
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Takahashi, Nobunori
AU  - Takahashi N
AD  - Department of Orthopedic Surgery, Aichi Medical University, Nagakute, Japan.
FAU - Asai, Shuji
AU  - Asai S
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Hirano, Yuji
AU  - Hirano Y
AD  - Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan.
FAU - Kanayama, Yasuhide
AU  - Kanayama Y
AD  - Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.
FAU - Yabe, Yuichiro
AU  - Yabe Y
AD  - Department of Rheumatology, Tokyo Shinjuku Medical Center, Tokyo, Japan.
FAU - Oguchi, Takeshi
AU  - Oguchi T
AD  - Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.
FAU - Fujibayashi, Takayoshi
AU  - Fujibayashi T
AD  - Department of Orthopedic Surgery, Konan Kosei Hospital, Konan, Japan.
FAU - Ishikawa, Hisato
AU  - Ishikawa H
AD  - Department of Orthopedic Surgery, Japanese Red Cross Aichi Medical Center Nagoya 
      Daiichi Hospital, Nagoya, Japan.
FAU - Hanabayashi, Masahiro
AU  - Hanabayashi M
AD  - Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya, 
      Japan.
FAU - Hattori, Yosuke
AU  - Hattori Y
AD  - Department of Orthopedic Surgery, National Hospital Organization Nagoya Medical 
      Center, Nagoya, Japan.
FAU - Suzuki, Mochihito
AU  - Suzuki M
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kishimoto, Kenji
AU  - Kishimoto K
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Ohashi, Yoshifumi
AU  - Ohashi Y
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Imaizumi, Takahiro
AU  - Imaizumi T
AD  - Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.
FAU - Imagama, Shiro
AU  - Imagama S
AUID- ORCID: 0000-0002-6951-8575
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kojima, Toshihisa
AU  - Kojima T
AD  - Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
SB  - IM
MH  - Humans
MH  - Male
MH  - Aged
MH  - *Antirheumatic Agents/adverse effects
MH  - Treatment Outcome
MH  - *Arthritis, Rheumatoid/drug therapy/epidemiology
MH  - Risk Factors
MH  - Longitudinal Studies
MH  - *Biological Products/therapeutic use
OTO - NOTNLM
OT  - Biological disease-modifying antirheumatic
OT  - drugs incident of adverse
OT  - events methotrexate
OT  - retention rate
OT  - rheumatoid arthritis
EDAT- 2022/08/18 06:00
MHDA- 2023/08/28 06:42
CRDT- 2022/08/17 02:22
PHST- 2022/04/13 00:00 [received]
PHST- 2022/07/18 00:00 [revised]
PHST- 2022/08/04 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2022/08/18 06:00 [pubmed]
PHST- 2022/08/17 02:22 [entrez]
AID - 6668878 [pii]
AID - 10.1093/mr/roac090 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2023 Aug 25;33(5):891-898. doi: 10.1093/mr/roac090.