PMID- 35976280
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20220825
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Print)
IS  - 0074-0276 (Linking)
VI  - 117
DP  - 2022
TI  - Lack of association of the KIR and HLA class I ligands with ZIKV infection in 
      south and southeast of Brazil.
PG  - e210194
LID - S0074-02762022000101119 [pii]
LID - 10.1590/0074-02760210194 [doi]
LID - e210194
AB  - BACKGROUND: Zika virus (ZIKV) is an emerging arbovirus associated with foetal 
      malformations and neurological complications. The infection is usually associated 
      with mild symptoms. The comparison between the allelic frequency of polymorphic 
      genes in symptomatic infected individuals in the population can clarify the 
      pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and 
      natural killer (NK) cells are recruited, whose activation depends on signaling 
      pathways activated by specific receptors, such as killer cell immunoglobulin-like 
      receptors (KIR). These molecules interact with human leukocyte antigen (HLA) 
      class I ligands and are encoded by polymorphic genes. OBJECTIVES: This study 
      aimed to evaluate the frequency of allelic variants of the genes encoding the KIR 
      receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 
      controls negative for the virus, and to evaluate the role of these variants for 
      ZIKV susceptibility. METHODS: KIR and HLA class I genes were genotyped using the 
      polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique. 
      FINDINGS: No significant differences in the frequency distribution of KIRs and 
      KIR-HLA in patients compared to controls were observed. MAIN CONCLUSIONS: KIR and 
      its HLA ligands might play a minor role in ZIKV infection in the south and 
      southeast Brazilian individuals.
FAU - Elpidio, Laise Nayana Sala
AU  - Elpidio LNS
AD  - Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e 
      Fisiopatologia, Departamento de Analises Clinicas e Biomedicina, Maringa, PR, 
      Brasil.
FAU - de Moraes, Amarilis Giaretta
AU  - de Moraes AG
AD  - Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e 
      Fisiopatologia, Departamento de Analises Clinicas e Biomedicina, Maringa, PR, 
      Brasil.
FAU - Langer, Ieda Bernadete Volkweis
AU  - Langer IBV
AD  - Farmaceutica responsavel pelo Laboratorio da Unidade Central de Nova Prata do 
      Iguacu, Nova Prata do Iguacu, PR, Brasil.
FAU - do Amaral, Greicy Cezar
AU  - do Amaral GC
AD  - 15 feminine Regional de Saude do Parana, Maringa, PR, Brasil.
FAU - Moretti, Maria Luiza
AU  - Moretti ML
AD  - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Departamento de 
      Medicina Interna, Campinas, SP, Brasil.
FAU - Garcia, Marcia Teixeira
AU  - Garcia MT
AD  - Universidade Estadual de Campinas, Divisao de Epidemiologia Hospitalar, Hospital 
      das Clinicas, Campinas, SP, Brasil.
FAU - Angerami, Rodrigo
AU  - Angerami R
AD  - Departamento de Vigilancia em Saude Publica de Campinas, Campinas, SP, Brasil.
FAU - Proenca-Modena, Jose Luiz
AU  - Proenca-Modena JL
AD  - Universidade Estadual de Campinas, Instituto de Biologia, Departamento de 
      Genetica, Microbiologia e Imunologia, Laboratorio de Virus Emergentes, Campinas, 
      SP, Brasil.
FAU - Bispo-Dos-Santos, Karina
AU  - Bispo-Dos-Santos K
AD  - Universidade Estadual de Campinas, Instituto de Biologia, Departamento de 
      Genetica, Microbiologia e Imunologia, Laboratorio de Virus Emergentes, Campinas, 
      SP, Brasil.
FAU - Martini, Matheus Cavalheiro
AU  - Martini MC
AD  - Universidade Estadual de Campinas, Instituto de Biologia, Departamento de 
      Genetica, Microbiologia e Imunologia, Laboratorio de Virus Emergentes, Campinas, 
      SP, Brasil.
FAU - Parise, Pierina Lorencini
AU  - Parise PL
AD  - Universidade Estadual de Campinas, Instituto de Biologia, Departamento de 
      Genetica, Microbiologia e Imunologia, Laboratorio de Virus Emergentes, Campinas, 
      SP, Brasil.
FAU - Ayo, Christiane Maria
AU  - Ayo CM
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Biologia 
      Molecular, Laboratorio de Imunogenetica, Sao Jose do Rio Preto, SP, Brasil.
FAU - de Mattos, Luiz Carlos
AU  - de Mattos LC
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Biologia 
      Molecular, Laboratorio de Imunogenetica, Sao Jose do Rio Preto, SP, Brasil.
FAU - Brandao, Cinara Cassia
AU  - Brandao CC
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Biologia 
      Molecular, Laboratorio de Imunogenetica, Sao Jose do Rio Preto, SP, Brasil.
FAU - Nogueira, Mauricio Lacerda
AU  - Nogueira ML
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Doencas 
      Infecciosas e Parasitarias, Laboratorio de Pesquisa em Virologia, Sao Jose do Rio 
      Preto, SP, Brasil.
FAU - Oliani, Denise Cristina Mos Vaz
AU  - Oliani DCMV
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Ginecologia e 
      Obstetricia, Sao Jose do Rio Preto, SP, Brasil.
FAU - Spegiorin, Ligia Cosentino Junqueira Franco
AU  - Spegiorin LCJF
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Departamento de Ginecologia e 
      Obstetricia, Sao Jose do Rio Preto, SP, Brasil.
FAU - de Lima Neto, Quirino Alves
AU  - de Lima Neto QA
AD  - Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e 
      Fisiopatologia, Departamento de Analises Clinicas e Biomedicina, Maringa, PR, 
      Brasil.
AD  - Universidade Estadual de Maringa, Laboratorio de Imunogenetica, Maringa, PR, 
      Brasil.
FAU - Visentainer, Jeane Eliete Laguila
AU  - Visentainer JEL
AUID- ORCID: 0000-0002-5815-7903
AD  - Universidade Estadual de Maringa, Programa de Pos-Graduacao em Biociencias e 
      Fisiopatologia, Departamento de Analises Clinicas e Biomedicina, Maringa, PR, 
      Brasil.
AD  - Universidade Estadual de Maringa, Laboratorio de Imunogenetica, Maringa, PR, 
      Brasil.
LA  - eng
PT  - Journal Article
DEP - 20220815
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Brazil
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Ligands
MH  - Receptors, KIR/genetics
MH  - *Zika Virus/genetics
MH  - *Zika Virus Infection/genetics
PMC - PMC9377541
EDAT- 2022/08/18 06:00
MHDA- 2022/08/20 06:00
PMCR- 2022/08/15
CRDT- 2022/08/17 11:12
PHST- 2021/05/31 00:00 [received]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/17 11:12 [entrez]
PHST- 2022/08/18 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
AID - S0074-02762022000101119 [pii]
AID - 10.1590/0074-02760210194 [doi]
PST - epublish
SO  - Mem Inst Oswaldo Cruz. 2022 Aug 15;117:e210194. doi: 10.1590/0074-02760210194. 
      eCollection 2022.