PMID- 35977665 OWN - NLM STAT- MEDLINE DCOM- 20221101 LR - 20230112 IS - 1873-4847 (Electronic) IS - 0955-2863 (Linking) VI - 110 DP - 2022 Dec TI - Time-restricted feeding rescues circadian disruption-aggravated progression of Alzheimer's disease in diabetic mice. PG - 109128 LID - S0955-2863(22)00196-6 [pii] LID - 10.1016/j.jnutbio.2022.109128 [doi] AB - Circadian rhythms, type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are closely related and interacted with each other. We have previously showed circadian disruption aggravated progression of AD in T2DM mice. Time-restricted feeding (TRF) is shown to be a potential synchronizer. This study aims to determine whether TRF has a protective effect against the circadian disruption-aggravated progression of AD in T2DM. 6-week-old male diabetic (db/db) mice and wildtype (wt/wt) mice were kept under normal 12:12 light/dark cycles or altered 6:18 light/dark cycles (dark extended to 18 h) with or without TRF (food restricted to 8 h during the active (dark) period). After 8 weeks, three behavioral tests (open field test, novel object recognition test, barnes maze test) were performed and the circadian gene expression, body weight, lipid levels and AD-associated tau phosphorylation were evaluated. We found altered light/dark cycles contributed to disruptive circadian rhythms in the hippocampus of db/db mice, while TRF prevented this effect. TRF also ameliorated circadian disruption-aggravated increased body weight and lipid accumulation in db/db mice. Importantly, the db/db mice under circadian disruption showed impaired cognition accompanied by increased tau phosphorylation, whereas TRF reversed these changes. The altered light/dark cycles only affected circadian rhythms but not other indicators like plasma/liver lipids, cognition and tau phosphorylation in the wt/wt mice. Collectively, TRF has a protective effect against altered light/dark cycles-aggravated AD progression in diabetic mice. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Peng, Xuemin AU - Peng X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Fan, Rongping AU - Fan R AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Xie, Lei AU - Xie L AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Shi, Xiaoli AU - Shi X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Wang, Fen AU - Wang F AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Xu, Weijie AU - Xu W AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Dong, Kun AU - Dong K AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Zhang, Shujun AU - Zhang S AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Ma, Delin AU - Ma D AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Yu, Xuefeng AU - Yu X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. FAU - Yang, Yan AU - Yang Y AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei, China. Electronic address: yangyan@tjh.tjmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220815 PL - United States TA - J Nutr Biochem JT - The Journal of nutritional biochemistry JID - 9010081 RN - 0 (Lipids) SB - IM MH - Mice MH - Animals MH - Male MH - *Alzheimer Disease MH - *Diabetes Mellitus, Type 2/complications MH - *Diabetes Mellitus, Experimental MH - Circadian Rhythm MH - Body Weight MH - Lipids OTO - NOTNLM OT - Alzheimer's disease OT - Circadian rhythms OT - Light OT - Time-restricted feeding OT - Type 2 diabetes mellitus EDAT- 2022/08/18 06:00 MHDA- 2022/11/02 06:00 CRDT- 2022/08/17 19:25 PHST- 2021/10/29 00:00 [received] PHST- 2022/07/09 00:00 [revised] PHST- 2022/07/14 00:00 [accepted] PHST- 2022/08/18 06:00 [pubmed] PHST- 2022/11/02 06:00 [medline] PHST- 2022/08/17 19:25 [entrez] AID - S0955-2863(22)00196-6 [pii] AID - 10.1016/j.jnutbio.2022.109128 [doi] PST - ppublish SO - J Nutr Biochem. 2022 Dec;110:109128. doi: 10.1016/j.jnutbio.2022.109128. Epub 2022 Aug 15.