PMID- 35979019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220819
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Effect of blood pressure on the mortality of the elderly population with 
      (pre)frailty: Results from NHANES 1999-2004.
PG  - 919956
LID - 10.3389/fcvm.2022.919956 [doi]
LID - 919956
AB  - BACKGROUNDS: The optimal blood pressure of elderly people with frailty or 
      prefrailty is still unclear. We aimed to explore the relationship between blood 
      pressure and mortality in the elderly with (pre)frailty. METHODS: A total of 528 
      participants aged 60 years and older were exacted for analyses of the association 
      between blood pressure and mortality from the database of the National Health and 
      Nutrition Examination Survey (NHANES) (1999-2004). Kaplan-Meier curves and 
      log-rank tests were used to investigate the differences in survival between 
      groups. Multivariable Cox regression and restricted cubic spline (RCS) analyses 
      were applied to explore the relationship between blood pressure and mortality. 
      RESULTS: During the median follow-up time of 116.5 [interquartile range (IQR) of 
      60-186] months, 363 all-cause deaths and 122 cardiac deaths were documented. For 
      all-cause mortality, more participants died with systolic blood pressure (SBP) < 
      110 mmHg and SBP >/= 170 mmHg (log-rank p = 0.004). After adjusting for 
      confounders, SBP < 110 mmHg [hazard ratio (HR) 1.52, 95% CI: 0.96-2.41] and SBP >/= 
      170 mmHg (HR 1.53, 95% CI: 1.09-2.15) had higher risks of all-cause mortality 
      compared with SBP within 130-150 mmHg. There were no significant differences in 
      all-cause mortality among DBP categories. A J-curve association was identified 
      between the SBP and hazard ratio for all-cause mortality (p for non-linear = 
      0.028), with 138.6 mmHg as the lowest hazard ratio of all-cause mortality; each 
      10 mmHg of SBP rise was associated with a 9% increased risk in all-cause 
      mortality (HR 1.09, 95% CI 1.00-1.18). Additionally, a non-linear relationship 
      was determined between SBP and the hazard ratio for cardiac deaths (p for 
      non-linear = 0.030), with 140.1 mmHg as the lowest hazard ratio of cardiac 
      deaths. When SBP was higher than 140.1 mmHg, each 10 mmHg rise in SBP was 
      associated with a 17% increased risk of cardiac deaths (HR 1.17, 95% CI: 
      1.02-1.34). CONCLUSION: Both lower and higher SBP levels are associated with 
      higher risks of all-cause mortality in older individuals with (pre)frailty. There 
      are J-shaped associations between SBP and mortality, with the optimal SBP being 
      approximately 140 mmHg for this population specifically.
CI  - Copyright (c) 2022 Li, Su, Su, Zuo, He, Yao, Yang, Zhang, Wang and Kong.
FAU - Li, Menghuan
AU  - Li M
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Su, Zhenyang
AU  - Su Z
AD  - School of Medicine, Southeast University, Nanjing, China.
FAU - Su, Hu
AU  - Su H
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zuo, Zhi
AU  - Zuo Z
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - He, Yuan
AU  - He Y
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yao, Wenming
AU  - Yao W
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yang, Jiaming
AU  - Yang J
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhang, Kerui
AU  - Zhang K
AD  - Gusu School, Nanjing Medical University, Soochow, China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Kong, Xiangqing
AU  - Kong X
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
AD  - Gusu School, Nanjing Medical University, Soochow, China.
LA  - eng
PT  - Journal Article
DEP - 20220801
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9376324
OTO - NOTNLM
OT  - association
OT  - blood pressure
OT  - elderly
OT  - frailty
OT  - mortality
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/19 06:00
MHDA- 2022/08/19 06:01
PMCR- 2022/01/01
CRDT- 2022/08/18 02:10
PHST- 2022/04/19 00:00 [received]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/08/18 02:10 [entrez]
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/08/19 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.919956 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Aug 1;9:919956. doi: 10.3389/fcvm.2022.919956. 
      eCollection 2022.