PMID- 35979218
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220819
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Case report: Bilateral central serous chorioretinopathy-like abnormalities in a 
      man with pulmonary arterial hypertension.
PG  - 983548
LID - 10.3389/fmed.2022.983548 [doi]
LID - 983548
AB  - BACKGROUND: Pulmonary arterial hypertension (PAH) leads to progressive increases 
      in pulmonary vascular resistance, right heart failure, and death if left 
      untreated. Ocular complications secondary to PAH were less reported. In this 
      study, we reported a case of bilateral visual loss and metamorphopsia in a 
      patient with PAH, who developed central serous chorioretinopathy (CSCR)-like 
      abnormalities and optic disc atrophy. CASE SUMMARY: A 45-year-old man presented 
      with decreasing central vision and metamorphopsia in both eyes. He had a history 
      of PAH and 6-year history of low-dose oral sildenafil treatment. Slit-lamp 
      examination revealed prominent dilated and tortuous episcleral and conjunctival 
      vessels. Ultrawide-field color picture showed retinal pigment epithelial mottling 
      and atrophy in ring-like configurations. Ultrawide-field autofluorescence showed 
      multiple irregular hyper-autofluorescence with a constellation-like pattern 
      surrounding the optic nerve head and macular region. Optical coherence tomography 
      angiography (OCTA) b-scan demonstrated CSCR-like changes. Swept-source optical 
      coherence tomography (SS-OCT) analysis showed optic nerve atrophy with enlarged 
      cup/disc ratio in right eye, which was confirmed with perimetry. Fluorescein 
      angiography (FA) showed marked leakage of macula and optic nerve head with time, 
      cystoid macular edema, early blocking with late staining of the flecks as shown 
      in the backgrounds of infrared and autofluorescence, and mild leakage in 
      peripheral retina. Indocyanine green angiography (ICGA) showed dilation, 
      tortuosity and congestion of all vortex veins without obvious leakage. 
      CONCLUSION: Undertreated PAH may cause the congestion of the choroid and induce 
      CSCR-like abnormalities.
CI  - Copyright (c) 2022 Zhou, Zhang, Gu, Zhou and Zhang.
FAU - Zhou, Xinrong
AU  - Zhou X
AD  - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's 
      Hospital), Shanghai Jiao Tong University, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
FAU - Zhang, Jingxiang
AU  - Zhang J
AD  - Nursing Department, People's Hospital of Huangdao District, Qingdao, China.
FAU - Gu, Limin
AU  - Gu L
AD  - Department of Ophthalmology, Shanghai Aier Eye Hospital, Shanghai, China.
FAU - Zhou, Hao
AU  - Zhou H
AD  - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's 
      Hospital), Shanghai Jiao Tong University, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
FAU - Zhang, Jingfa
AU  - Zhang J
AD  - Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's 
      Hospital), Shanghai Jiao Tong University, Shanghai, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
LA  - eng
PT  - Case Reports
DEP - 20220801
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9376321
OTO - NOTNLM
OT  - case report
OT  - central serous chorioretinopathy
OT  - fundus abnormalities
OT  - hypertension - complications
OT  - macular edema
OT  - pulmonary arterial hypertension
OT  - vascular disease
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/19 06:00
MHDA- 2022/08/19 06:01
PMCR- 2022/08/01
CRDT- 2022/08/18 02:14
PHST- 2022/07/01 00:00 [received]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/08/18 02:14 [entrez]
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/08/19 06:01 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 10.3389/fmed.2022.983548 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Aug 1;9:983548. doi: 10.3389/fmed.2022.983548. 
      eCollection 2022.