PMID- 35979530
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20220819
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 28
DP  - 2022
TI  - Anastomosing Haemangioma: Report of Three Cases With Molecular and 
      Immunohistochemical Studies and Comparison With Well-Differentiated Angiosarcoma.
PG  - 1610498
LID - 10.3389/pore.2022.1610498 [doi]
LID - 1610498
AB  - Anastomosing haemangioma (AH) is a newly described distinct vascular neoplasm 
      that histologically may confuse with well-differentiated angiosarcoma (AS) for 
      those who are unfamiliar with this rare entity. We aimed to identify molecular 
      genetic differences between AHs and ASs by carrying out immunohistochemistry 
      (IHC), fluorescence in situ hybridization (FISH), and next-generation sequencing 
      (NGS). Immunohistochemically, all six cases showed positivity for cyclinD1 and 
      pERK. All cases of AH showed focal weak positive reaction for p53 and MIB-1, and 
      the IHCs for HIF-1alpha were all negative for all three cases. Those three cases of 
      angiosarcoma revealed strong, diffuse positivity for p53, 50%-70% MIB-1 
      labelling, and multifocal, moderate to strong HIF-1alpha expression. To further 
      clarify the difference in p53 expression, we carried out a FISH which revealed 
      17p polysomy in all three ASs whereas copy number aberration was absent in the AH 
      group. In one AH case, the GNA11 c.627G > T nucleotide variant was detected. Due 
      to the rarity and overlapping morphological features, AH might be difficult to 
      separate from other vascular tumours, in particular from well-differentiated AS 
      also featured by mild hyperchromatic, hobnail-like endothelial cells. The 
      potential molecular differences between these two entities presented here may be 
      used in support of the correct diagnosis.
CI  - Copyright (c) 2022 Chang Chien, Beke, Mehes and Mokanszki.
FAU - Chang Chien, Yi-Che
AU  - Chang Chien YC
AD  - Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 
      Hungary.
FAU - Beke, Livia
AU  - Beke L
AD  - Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 
      Hungary.
FAU - Mehes, Gabor
AU  - Mehes G
AD  - Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 
      Hungary.
FAU - Mokanszki, Attila
AU  - Mokanszki A
AD  - Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 
      Hungary.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220801
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Endothelial Cells/pathology
MH  - *Hemangioma/genetics/pathology
MH  - *Hemangiosarcoma/genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Tumor Suppressor Protein p53/genetics
PMC - PMC9376968
OTO - NOTNLM
OT  - GNA11 mutation
OT  - anastomosing haemangioma
OT  - angiosarcoma
OT  - fluorescence in situ hybridization (FISH)
OT  - immunohistochemistry (IHC)
OT  - next-generation sequencing (NGS)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/19 06:00
MHDA- 2022/08/20 06:00
PMCR- 2022/08/01
CRDT- 2022/08/18 02:22
PHST- 2022/04/07 00:00 [received]
PHST- 2022/06/23 00:00 [accepted]
PHST- 2022/08/18 02:22 [entrez]
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 1610498 [pii]
AID - 10.3389/pore.2022.1610498 [doi]
PST - epublish
SO  - Pathol Oncol Res. 2022 Aug 1;28:1610498. doi: 10.3389/pore.2022.1610498. 
      eCollection 2022.