PMID- 35979675
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221011
IS  - 1540-8191 (Electronic)
IS  - 0886-0440 (Linking)
VI  - 37
IP  - 11
DP  - 2022 Nov
TI  - Specific causes of death among patients with cardiac sarcoma in the United 
      States-An analysis of The Surveillance, Epidemiology, and End Results (SEER) 
      Program.
PG  - 3961-3963
LID - 10.1111/jocs.16857 [doi]
AB  - Representing 10%-25% of the primary cardiac neoplasms, primary malignant cardiac 
      tumors (PMCT) have a poor prognosis, yet with rare incidence. Constituting more 
      than 50% of the PMCT, cardiac sarcoma has increased not only in incidence over 
      the past five decades but also in severity. Patients with PMCTs, especially 
      sarcomas, have the worst prognosis when compared with other cardiac or 
      extracardiac tumors. This retrospective study was performed using SEER*stat 
      software, latest version 8.3.9.2(5) by accessing seer 18 registries plus data 
      (excl AK) Nov 2020 Sub (2000-2018) for standard mortality ratio (SMR). A total of 
      235 patients were identified of whom 49.4% were females. Most of our patients 
      were Stage 4 (n = 81) and distant in location (n = 92). The most common treatment 
      method was tumor-directed surgery (n = 164), chemotherapy (n = 146), and 
      radiotherapy (n = 55). Furthermore, other associated cancers with cardiac sarcoma 
      were rare, with ten cases with lung and bronchus cancer (SMR: 37.95, 95% 
      confidence interval [CI]: 18.2, 69.8), four with bone and joints (SMR: 1726.05, 
      95% CI: 470.2, 4419.3). During a 5-year follow-up, 235 patients died primarily 
      due to cardiac sarcoma (n = 182, 77.4%), other cancers (n = 34, 14.4%), and other 
      noncancerous causes (n = 19, 8%), while the noncancerous causes were attributed 
      mainly to cardiovascular diseases (n = 4, 21%, SMR: 4.95, 95% CI: 1.35, 12.67), 
      septicemia (n = 2, 10.5%, SMR: 41.23, 95% CI: 4.99, 148.95).
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Awad, Ahmed K
AU  - Awad AK
AUID- ORCID: 0000-0001-6647-1866
AD  - Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
FAU - Elgenidy, Anas
AU  - Elgenidy A
AUID- ORCID: 0000-0002-4532-8574
AD  - Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - Afifi, Ahmed M
AU  - Afifi AM
AD  - Department of Gastroenterology, Hepatology and Nutrition Diseases, MD Anderson 
      Cancer Center, Houston, Texas, USA.
FAU - Sa, Michel Pompeu
AU  - Sa MP
AUID- ORCID: 0000-0001-5356-2996
AD  - Department of Cardiothoracic Surgery, Lankenau Heart Institute, Lankenau Medical 
      Center, Main Line Health, Wynnewood, Pennsylvania, USA.
AD  - Department of Cardiothoracic Surgery Research, Lankenau Institute for Medical 
      Research, Wynnewood, Pennsylvania, USA.
FAU - Ramlawi, Basel
AU  - Ramlawi B
AD  - Department of Cardiothoracic Surgery, Lankenau Heart Institute, Lankenau Medical 
      Center, Main Line Health, Wynnewood, Pennsylvania, USA.
AD  - Department of Cardiothoracic Surgery Research, Lankenau Institute for Medical 
      Research, Wynnewood, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20220818
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
SB  - IM
MH  - Cause of Death
MH  - Female
MH  - *Heart Neoplasms/pathology
MH  - Humans
MH  - Male
MH  - *Mediastinal Neoplasms
MH  - Retrospective Studies
MH  - SEER Program
MH  - *Sarcoma/epidemiology
MH  - *Thymus Neoplasms
MH  - United States/epidemiology
OTO - NOTNLM
OT  - SEER-database
OT  - cardiac neoplasms
OT  - cardiac sarcoma
EDAT- 2022/08/19 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/08/18 03:42
PHST- 2022/07/29 00:00 [received]
PHST- 2022/08/11 00:00 [accepted]
PHST- 2022/08/19 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/08/18 03:42 [entrez]
AID - 10.1111/jocs.16857 [doi]
PST - ppublish
SO  - J Card Surg. 2022 Nov;37(11):3961-3963. doi: 10.1111/jocs.16857. Epub 2022 Aug 
      18.