PMID- 3597985
OWN - NLM
STAT- MEDLINE
DCOM- 19870803
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 10
IP  - 1
DP  - 1987 Jul
TI  - Measurement of ventricular volumes in the dog by nuclear magnetic resonance 
      imaging.
PG  - 170-7
AB  - Nuclear magnetic resonance (NMR) imaging is a new, noninvasive approach for 
      imaging the cardiovascular system. Being a three-dimensional technique, NMR 
      imaging has the capability of measuring volumes without the need for assumptions 
      regarding ventricular geometry. In this study, the technique was validated in 19 
      excised dog hearts, filled with silicone-rubber, imaged using a multislice 
      spin-echo sequence. The volume of the cavity in each slice was calculated from 
      the number of pixels outlined for each slice multiplied by the pixel volume. 
      Ventricular volumes measured by NMR imaging were highly correlated with cast 
      volumes measured by water displacement: right ventricle (RV):RVNMR = 1.05 RVcast 
      - 1.62; r = 0.99, SEE = 0.96 ml; left ventricle (LV):LVNMR = 0.98 LVcast + 0.35, 
      r = 0.98, SEE = 1.48 ml. After validation in casts, NMR imaging volumes were 
      measured in eight living dogs using a multiphasic gated technique to obtain 
      images at 5, 105, 205, 305 and 405 ms after the QRS complex. Cardiac output (CO) 
      and stroke volume (SV) measured by NMR imaging were significantly correlated with 
      thermodilution (TD) measurements (CONMR = 0.63 COTD + 0.51 liters/min; r = 0.78, 
      SEE = 0.57 liters/min; SVNMR = 0.67 SVTD + 1.95 ml; SEE = 5.58 ml). Right and 
      left stroke volumes were closely related (LVSVNMR = 0.9 RVSVNMR + 1.75; r = 0.94, 
      SEE = 4.32 ml), with the slope and intercept of the regression line showing no 
      difference from 1 and 0, respectively. However, volumes determined by NMR imaging 
      underestimated the thermodilution measurements, presumably reflecting the 
      inability to obtain a true systolic image with the present sampling 
      rate.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Markiewicz, W
AU  - Markiewicz W
FAU - Sechtem, U
AU  - Sechtem U
FAU - Kirby, R
AU  - Kirby R
FAU - Derugin, N
AU  - Derugin N
FAU - Caputo, G C
AU  - Caputo GC
FAU - Higgins, C B
AU  - Higgins CB
LA  - eng
GR  - 5R01-32283/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Animals
MH  - *Blood Volume
MH  - *Coronary Circulation
MH  - Dogs
MH  - Heart Ventricles
MH  - *Magnetic Resonance Spectroscopy
MH  - Models, Anatomic
MH  - Thermodilution/methods
EDAT- 1987/07/01 00:00
MHDA- 1987/07/01 00:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 1987/07/01 00:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - S0735-1097(87)80176-6 [pii]
AID - 10.1016/s0735-1097(87)80176-6 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1987 Jul;10(1):170-7. doi: 10.1016/s0735-1097(87)80176-6.